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Patricia N. Tonin

Patricia N. Tonin

D-Index & Metrics

Genetics

D-Index
60
Citations
30063
World Ranking
3102
National Ranking
112

Overview

Patricia N. Tonin is affiliated with McGill University in Canada and has a notable research focus within biochemistry, genetics, and molecular biology, alongside medicine. Their academic contributions span 40 publications in biochemistry, genetics, and molecular biology and 13 in medicine, with particular attention to genetics and molecular biology subfields.

Their research work encompasses topics related to BRCA gene mutations in cancer, DNA repair mechanisms, and the therapeutic potential of PARP inhibition in cancer. They further explore cancer genomics and diagnostics, ovarian cancer diagnosis and treatment, CRISPR and genetic engineering, as well as genetic factors contributing to colorectal cancer.

  • BRCA gene mutations in cancer
  • DNA Repair Mechanisms
  • PARP inhibition in cancer therapy
  • Cancer Genomics and Diagnostics
  • Ovarian cancer diagnosis and treatment
  • CRISPR and Genetic Engineering
  • Genetic factors in colorectal cancer

Tonin has contributed papers published in various journals. Key publications include:

  • Whole-exome sequencing of non- BRCA1/BRCA2 mutation carrier cases at high-risk for hereditary breast/ovarian cancer, 2020, Human Mutation
  • Literature Review of BARD1 as a Cancer Predisposing Gene with a Focus on Breast and Ovarian Cancers, 2020, Genes
  • Lessons learned from understanding chemotherapy resistance in epithelial tubo-ovarian carcinoma from BRCA1and BRCA2mutation carriers, 2020, Seminars in Cancer Biology
  • A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene, 2021, Genome Medicine
  • Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families, 2021, npj Breast Cancer

They have frequently published in journals such as Genes, Cancers, and bioRxiv (Cold Spring Harbor Laboratory), with additional articles in Human Mutation and Seminars in Cancer Biology.

  • Genes
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Human Mutation
  • Seminars in Cancer Biology

Among frequent coauthors collaborating with Tonin are Anne-Marie Mes-Masson, Jiannis Ragoussis, Wejdan M. Alenezi, Caitlin T. Fierheller, and William D. Foulkes.

  • Anne-Marie Mes-Masson
  • Jiannis Ragoussis
  • Wejdan M. Alenezi
  • Caitlin T. Fierheller
  • William D. Foulkes

Best Publications

  • A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

    Yoshio Miki;Jeff Swensen;Donna Shattuck-Eidens;P. Andrew Futreal

  • Identification of the breast cancer susceptibility gene BRCA2

    Wooster R;Bignell G;Lancaster J;Swift S

  • Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

    D Ford;D F Easton;M Stratton;S Narod

  • ARID1A mutations in endometriosis-associated ovarian carcinomas.

    Kimberly C. Wiegand;Sohrab P. Shah;Osama M. Al-Agha;Yongjun Zhao

  • Hereditary breast cancer : pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage

    Joseph N. Marcus;Patrice Watson;David L. Page;Steven A. Narod

  • Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

    J. Simard;P. Tonin;F. Durocher;K. Morgan

  • Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families

    P Tonin;B Weber;K Offit;F Couch

  • Mutation analysis of the BRCA2 gene in 49 site–specific breast cancer families

    C M Phelan;J M Lancaster;P Tonin;C Gumbs

  • Haplotype and phenotype analysis of nine recurrent BRCA2 mutations in 111 families: results of an international study

    Susan L. Neuhausen;Sylvie Mazoyer;Lori Friedman;Michael Stratton

  • Analysis of PALB2/FANCN-associated breast cancer families

    Marc Tischkowitz;Bing Xia;Nelly Sabbaghian;Jorge S. Reis-Filho

  • Mutations in BRCA1 and BRCA2 in breast cancer families: are there more breast cancer-susceptibility genes?

    Olga M. Serova;Sylvie Mazoyer;Nadine Puget;Valérie Dubois

  • Influence of BRCA1 mutations on nuclear grade and estrogen receptor status of breast carcinoma in Ashkenazi Jewish women

    Stephen E. Karp;Patricia N. Tonin;Louis R. Bégin;John J. Martinez

  • Molecular description of a 3D in vitro model for the study of epithelial ovarian cancer (EOC).

    Magdalena Zietarska;Christine M. Maugard;Christine M. Maugard;Abdelali Filali-Mouhim;Mona Alam-Fahmy

  • CHARACTERIZATION OF FOUR NOVEL EPITHELIAL OVARIAN CANCER CELL LINES

    D. M. Provencher;H. Lounis;L. Champoux;M. Tétrault

  • A significant response to neoadjuvant chemotherapy in BRCA1/2 related breast cancer

    P O Chappuis;Jan Goffin;N Wong;C Perret

  • Founder BRCA1 and BRCA2 mutations in French Canadian breast and ovarian cancer families.

    Patricia N. Tonin;Anne-Marie Mes-Masson;P. Andrew Futreal;Kenneth Morgan

  • Characterization of Ovarian Cancer Ascites on Cell Invasion, Proliferation, Spheroid Formation, Gene Expression in an In Vitro Model of Epithelial Ovarian Cancer

    Marie-Line Puiffe;Cecile Le Page;Abdelali Filali-Mouhim;Magdalena Zietarska

  • Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12-q21

    Nazneen Rahman;Laura Arbour;Patricia Tonin;Jane Renshaw

  • High allele loss rates at 17q12-q21 in breast and ovarian tumors from BRCAl-linked families. The Breast Cancer Linkage Consortium.

    R. S. Cornelis;S. L. Neuhausen;O. Johansson;A. Arason

  • Erratum: Identification of the breast cancer susceptibility gene BRCA2

    Richard Wooster;Graham Bignell;Jonathan Lancaster;Sally Swift

Frequent Co-Authors

Diane Provencher
Diane Provencher University of Montreal
Anne-Marie Mes-Masson
Anne-Marie Mes-Masson University of Montreal
William D. Foulkes
William D. Foulkes McGill University
Steven A. Narod
Steven A. Narod University of Toronto
Parviz Ghadirian
Parviz Ghadirian University of Montreal
Celia M. T. Greenwood
Celia M. T. Greenwood McGill University
Henry T. Lynch
Henry T. Lynch Creighton University
Thomas J. Hudson
Thomas J. Hudson Ontario Institute for Cancer Research
Gilbert M. Lenoir
Gilbert M. Lenoir International Agency For Research On Cancer
Kenneth Morgan
Kenneth Morgan McGill University

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