Benjamin P C Chen mainly focuses on Molecular biology, Cell biology, Transcription factor, DNA and Protein kinase A. Benjamin P C Chen combines subjects such as Autophosphorylation and Kinase activity with his study of Molecular biology. His Cell biology research integrates issues from Endothelial stem cell and DNA damage.
His DNA damage study integrates concerns from other disciplines, such as CHEK1, Cell cycle checkpoint, Senescence, Downregulation and upregulation and Telomere. Within the field of Phosphorylation and Kinase Benjamin P C Chen studies Protein kinase A. The concepts of his Phosphorylation study are interwoven with issues in Histone, Phosphorylated Histone H2AX, Protein subunit and MDC1.
His scientific interests lie mostly in Cell biology, Molecular biology, DNA damage, DNA repair and Cancer research. His Cell biology research includes themes of DNA and Ku70. As a member of one scientific family, he mostly works in the field of Molecular biology, focusing on Kinase activity and, on occasion, Autophosphorylation, Kinetochore and Cell cycle.
His studies in DNA damage integrate themes in fields like Carcinogenesis, CHEK1, G2-M DNA damage checkpoint and Stem cell. The DNA repair study combines topics in areas such as Replication protein A, Homologous recombination and DNA replication. In his work, Cell is strongly intertwined with Cancer, which is a subfield of Cancer research.
His main research concerns Cancer research, Cell biology, Receptor, Protein kinase A and Dentate gyrus. The study incorporates disciplines such as Immune checkpoint, Radioresistance, Immune system and Cancer cell in addition to Cancer research. His work deals with themes such as DNA damage, DNA, Regulator and Protein subunit, which intersect with Cell biology.
His studies deal with areas such as Lipid peroxidation, Apoptosis, Cell division, Endogeny and Stem cell as well as DNA damage. He combines topics linked to Kinase with his work on Receptor. Specifically, his work in Protein kinase A is concerned with the study of DNA-PKcs.
The scientist’s investigation covers issues in Cell biology, Cancer research, Protein kinase A, Signal transduction and Receptor. Benjamin P C Chen has included themes like Gut flora, Superoxide dismutase, DNA damage, Lipid peroxidation and Apoptosis in his Cell biology study. His Cancer research study integrates concerns from other disciplines, such as Phenotype, Cancer cell, Multiprotein complex and Radioresistance.
His Protein kinase A research is multidisciplinary, relying on both Ku70, Protein subunit, Telomere, DNA and Telomerase. While the research belongs to areas of Ku70, Benjamin P C Chen spends his time largely on the problem of Cell cycle checkpoint, intersecting his research to questions surrounding DNA replication. The various areas that Benjamin P C Chen examines in his Receptor study include Antibody and Kinase.
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ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks
Sandeep Burma;Benjamin P. Chen;Michael Murphy;Akihiro Kurimasa.
Journal of Biological Chemistry (2001)
Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
Utz Herbig;Wendy A Jobling;Benjamin P.C Chen;David J Chen.
Molecular Cell (2004)
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks
Naoya Uematsu;Eric Weterings;Ken Ichi Yano;Keiko Morotomi-Yano.
Journal of Cell Biology (2007)
Role of non-homologous end joining (NHEJ) in maintaining genomic integrity
Sandeep Burma;Benjamin P.C. Chen;David J. Chen.
DNA Repair (2006)
Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10.
Benjamin P C Chen;Curt D. Wolfgang;Tsonwin Hai.
Molecular and Cellular Biology (1996)
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
Benjamin P.C. Chen;Naoya Uematsu;Junya Kobayashi;Yaniv Lerenthal.
Journal of Biological Chemistry (2007)
DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress.
Benjamin P C Chen;Yi Shuan Li;Yihua Zhao;Kuang Den Chen.
Physiological Genomics (2001)
Cell Cycle Dependence of DNA-dependent Protein Kinase Phosphorylation in Response to DNA Double Strand Breaks
Benjamin P.C. Chen;Doug W. Chan;Junya Kobayashi;Sandeep Burma.
Journal of Biological Chemistry (2005)
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
Anthony J. Davis;Benjamin P.C. Chen;David J. Chen.
DNA Repair (2014)
ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms.
Benjamin P C Chen;Guosheng Liang;James Whelan;Tsonwin Hai.
Journal of Biological Chemistry (1994)
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