2007 - Fellow of the American Association for the Advancement of Science (AAAS)
John Y.-J. Shyy mostly deals with Cell biology, Gene expression, Signal transduction, Molecular biology and Mechanotransduction. His work deals with themes such as Endothelial stem cell and Cell adhesion, which intersect with Cell biology. His Signal transduction research incorporates themes from Nitric oxide synthase and Nitric Oxide Synthase Type III.
His Molecular biology study incorporates themes from Regulation of gene expression, Shear stress, Transcription factor and Monocyte. While the research belongs to areas of Mechanotransduction, John Y.-J. Shyy spends his time largely on the problem of Integrin, intersecting his research to questions surrounding Tyrosine phosphorylation, Focal adhesion and Extracellular matrix. His biological study spans a wide range of topics, including Internal medicine and Endocrinology.
His scientific interests lie mostly in Cell biology, Internal medicine, Endothelium, Endocrinology and Signal transduction. His Cell biology research integrates issues from Endothelial stem cell, Biochemistry and Shear stress. His studies deal with areas such as Oxidative stress, Endothelial dysfunction, Sirtuin 1, ICAM-1 and Pharmacology as well as Endothelium.
In his research, Nitric Oxide Synthase Type III is intimately related to AMP-activated protein kinase, which falls under the overarching field of Endocrinology. The Signal transduction study combines topics in areas such as Molecular biology, Mediator and Gene expression. As a member of one scientific family, John Y.-J. Shyy mostly works in the field of Mechanotransduction, focusing on Integrin and, on occasion, Focal adhesion.
His scientific interests lie mostly in Cell biology, Internal medicine, Endothelial dysfunction, Pharmacology and Endothelium. His Cell biology study combines topics from a wide range of disciplines, such as Transcription factor and Gene knockdown. His Internal medicine research includes elements of Endocrinology and Type 2 Diabetes Mellitus.
His Endothelial dysfunction research is multidisciplinary, incorporating perspectives in KLF2, AMPK, Disease, Obstructive sleep apnea and Biomarker. His study in Histone extends to Endothelium with its themes. His work in Protein kinase A addresses subjects such as Enos, which are connected to disciplines such as microRNA.
John Y.-J. Shyy mostly deals with Pharmacology, Endothelial dysfunction, Endothelium, Pathogenesis and Cell biology. The concepts of his Pharmacology study are interwoven with issues in Angiotensin II, RNA interference, Membrane protein and Enzyme. His Endothelial dysfunction study frequently links to related topics such as Protein kinase A.
His Endothelium research includes themes of Ubiquitin, Mdm2, Promoter, RNA polymerase II and Epigenetics. His study in Pathogenesis is interdisciplinary in nature, drawing from both Right ventricular hypertrophy, Pulmonary hypertension, Growth factor, CTGF and Transforming growth factor. His Cell biology research is multidisciplinary, relying on both KLF2, microRNA and Enos.
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AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
Yu Li;Shanqin Xu;Maria M. Mihaylova;Bin Zheng.
Cell Metabolism (2011)
Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells
Shu Chien;Song Li;John Y-J. Shyy.
Mechanotransduction in Response to Shear Stress ROLES OF RECEPTOR TYROSINE KINASES, INTEGRINS, AND Shc
Kuang-Den Chen;Yi-Shuan Li;Michael Kim;Song Li.
Journal of Biological Chemistry (1999)
Role of Integrins in Endothelial Mechanosensing of Shear Stress
John Y.-J. Shyy;Shu Chien.
Circulation Research (2002)
Fluid Shear Stress Activation of Focal Adhesion Kinase LINKING TO MITOGEN-ACTIVATED PROTEIN KINASES
Song Li;Michael Kim;Ying-Li Hu;Shila Jalali.
Journal of Biological Chemistry (1997)
Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands
Shila Jalali;Miguel A. del Pozo;Kuang-Den Chen;Hui Miao.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Role of integrins in cellular responses to mechanical stress and adhesion
John Y-J Shyy;Shu Chien.
Current Opinion in Cell Biology (1997)
DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress.
Benjamin P C Chen;Yi Shuan Li;Yihua Zhao;Kuang Den Chen.
Physiological Genomics (2001)
Fluorescence Proteins, Live-Cell Imaging, and Mechanobiology: Seeing Is Believing
Yingxiao Wang;John Y.-J. Shyy;Shu Chien.
Annual Review of Biomedical Engineering (2008)
MicroRNA-21 targets peroxisome proliferators-activated receptor-α in an autoregulatory loop to modulate flow-induced endothelial inflammation
Jing Zhou;Kuei Chun Wang;Wei Wu;Shankar Subramaniam.
Proceedings of the National Academy of Sciences of the United States of America (2011)
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