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D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
23337
World Ranking
4074
National Ranking
2003

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John Y.-J. Shyy is affiliated with the University of California, San Diego in the United States. Their research spans multiple fields, with a significant focus on medicine as well as biochemistry, genetics, and molecular biology.

Their work concentrates on several main topics, including:

  • Pulmonary Hypertension Research and Treatments
  • Kruppel-like factors research
  • MicroRNA in disease regulation
  • Cancer-related molecular mechanisms research
  • Inflammasome and immune disorders
  • RNA modifications and cancer
  • Metabolism, Diabetes, and Cancer

Main subfields of study related to their publications include molecular biology, pulmonary and respiratory medicine, cancer research, cardiology and cardiovascular medicine, and surgery.

John Y.-J. Shyy has published extensively in various scientific venues. The frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation
  • Proceedings of the National Academy of Sciences
  • Arteriosclerosis Thrombosis and Vascular Biology
  • Circulation Research

Among their recent publications are the following papers:

  • "SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2," 2021, Circulation Research
  • "MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension," 2020, Circulation
  • "Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension," 2021, American Journal of Physiology-Cell Physiology
  • "SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions," 2021, Proceedings of the National Academy of Sciences

Collaborations are also a notable aspect of their research output. Frequent co-authors include:

  • Ming He
  • Patricia A. Thistlethwaite
  • Jason X.-J. Yuan
  • Atul Malhotra
  • Pritesh Jain

John Y.-J. Shyy has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2007.

Best Publications

  • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.

    Yu Li;Shanqin Xu;Maria M. Mihaylova;Bin Zheng

  • Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells

    Shu Chien;Song Li;John Y-J. Shyy

  • Role of Integrins in Endothelial Mechanosensing of Shear Stress

    John Y.-J. Shyy;Shu Chien

  • Mechanotransduction in Response to Shear Stress ROLES OF RECEPTOR TYROSINE KINASES, INTEGRINS, AND Shc

    Kuang-Den Chen;Yi-Shuan Li;Michael Kim;Song Li

  • Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands

    Shila Jalali;Miguel A. del Pozo;Kuang-Den Chen;Hui Miao

  • Fluid Shear Stress Activation of Focal Adhesion Kinase LINKING TO MITOGEN-ACTIVATED PROTEIN KINASES

    Song Li;Michael Kim;Ying-Li Hu;Shila Jalali

  • SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.

    Yuyang Lei;Jiao Zhang;Jiao Zhang;Cara R. Schiavon;Ming He

  • Role of integrins in cellular responses to mechanical stress and adhesion

    John Y-J Shyy;Shu Chien

  • MicroRNA-21 targets peroxisome proliferators-activated receptor-α in an autoregulatory loop to modulate flow-induced endothelial inflammation

    Jing Zhou;Kuei Chun Wang;Wei Wu;Shankar Subramaniam

  • DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress.

    Benjamin P C Chen;Yi Shuan Li;Yihua Zhao;Kuang Den Chen

  • Fluorescence Proteins, Live-Cell Imaging, and Mechanobiology: Seeing Is Believing

    Yingxiao Wang;John Y.-J. Shyy;Shu Chien

  • The antiinflammatory effect of laminar flow: The role of PPARγ, epoxyeicosatrienoic acids, and soluble epoxide hydrolase

    Yi Liu;Yingjia Zhang;Kara Schmelzer;Tzong Shyuan Lee

  • Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

    Wei Wu;Han Xiao;Andrés Laguna-Fernandez;Guadalupe Villarreal

  • Simvastatin Induces Heme Oxygenase-1 A Novel Mechanism of Vessel Protection

    Tzong-Shyuan Lee;Chih-Chieh Chang;Yi Zhu;John Y.-J. Shyy

  • AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633.

    Zhen Chen;I-Chen Peng;Wei Sun;Mei I. Su

  • miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4

    Hsin Yi Chen;Yu Min Lin;Yu Min Lin;Hsiang Ching Chung;Hsiang Ching Chung;Yaw Dong Lang

  • Molecular mechanism of endothelial growth arrest by laminar shear stress

    Kurt Lin;Pin Pin Hsu;Benjamin P. Chen;Suli Yuan

  • Nitric Oxide Regulates Monocyte Chemotactic Protein-1

    Philip S. Tsao;Bing Yin Wang;Ricardo Buitrago;John Y.J. Shyy

  • Shear stress induction of the tissue factor gene.

    Ming Chao Lin;Fanny Almus-Jacobs;Hsuan Hsu Chen;Graham C N Parry

  • The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression.

    John Y. J. Shyy;Ming-Chao Lin;Jiahuai Han;Yujuan Lu

Frequent Co-Authors

Shu Chien
Shu Chien University of California, San Diego
Hsien-Da Huang
Hsien-Da Huang Chinese University of Hong Kong, Shenzhen
Shankar Subramaniam
Shankar Subramaniam University of California, San Diego
Tzong-Shyuan Lee
Tzong-Shyuan Lee National Taiwan University
Song Li
Song Li University of California, Los Angeles
Ming-Daw Tsai
Ming-Daw Tsai Academia Sinica
Jason X.-J. Yuan
Jason X.-J. Yuan University of California, San Diego
Atul Malhotra
Atul Malhotra University of California, San Diego
Bruce D. Hammock
Bruce D. Hammock University of California, Davis
Benjamin P C Chen
Benjamin P C Chen The University of Texas Southwestern Medical Center

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