What is he best known for?
The fields of study he is best known for:
John Y.-J. Shyy mostly deals with Cell biology, Gene expression, Signal transduction, Molecular biology and Mechanotransduction.
His work deals with themes such as Endothelial stem cell and Cell adhesion, which intersect with Cell biology.
His Signal transduction research incorporates themes from Nitric oxide synthase and Nitric Oxide Synthase Type III.
His Molecular biology study incorporates themes from Regulation of gene expression, Shear stress, Transcription factor and Monocyte.
While the research belongs to areas of Mechanotransduction, John Y.-J. Shyy spends his time largely on the problem of Integrin, intersecting his research to questions surrounding Tyrosine phosphorylation, Focal adhesion and Extracellular matrix.
His biological study spans a wide range of topics, including Internal medicine and Endocrinology.
His most cited work include:
- AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice (941 citations)
- Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells (523 citations)
- Mechanotransduction in Response to Shear Stress ROLES OF RECEPTOR TYROSINE KINASES, INTEGRINS, AND Shc (504 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Cell biology, Internal medicine, Endothelium, Endocrinology and Signal transduction.
His Cell biology research integrates issues from Endothelial stem cell, Biochemistry and Shear stress.
His studies deal with areas such as Oxidative stress, Endothelial dysfunction, Sirtuin 1, ICAM-1 and Pharmacology as well as Endothelium.
In his research, Nitric Oxide Synthase Type III is intimately related to AMP-activated protein kinase, which falls under the overarching field of Endocrinology.
The Signal transduction study combines topics in areas such as Molecular biology, Mediator and Gene expression.
As a member of one scientific family, John Y.-J. Shyy mostly works in the field of Mechanotransduction, focusing on Integrin and, on occasion, Focal adhesion.
He most often published in these fields:
- Cell biology (48.37%)
- Internal medicine (26.63%)
- Endothelium (26.63%)
What were the highlights of his more recent work (between 2018-2021)?
- Cell biology (48.37%)
- Internal medicine (26.63%)
- Endothelial dysfunction (15.22%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Cell biology, Internal medicine, Endothelial dysfunction, Pharmacology and Endothelium.
His Cell biology study combines topics from a wide range of disciplines, such as Transcription factor and Gene knockdown.
His Internal medicine research includes elements of Endocrinology and Type 2 Diabetes Mellitus.
His Endothelial dysfunction research is multidisciplinary, incorporating perspectives in KLF2, AMPK, Disease, Obstructive sleep apnea and Biomarker.
His study in Histone extends to Endothelium with its themes.
His work in Protein kinase A addresses subjects such as Enos, which are connected to disciplines such as microRNA.
Between 2018 and 2021, his most popular works were:
- Germline BMP9 mutation causes idiopathic pulmonary arterial hypertension (33 citations)
- Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications. (16 citations)
- ACE2, Metformin, and COVID-19. (9 citations)
In his most recent research, the most cited papers focused on:
John Y.-J. Shyy mostly deals with Pharmacology, Endothelial dysfunction, Endothelium, Pathogenesis and Cell biology.
The concepts of his Pharmacology study are interwoven with issues in Angiotensin II, RNA interference, Membrane protein and Enzyme.
His Endothelial dysfunction study frequently links to related topics such as Protein kinase A.
His Endothelium research includes themes of Ubiquitin, Mdm2, Promoter, RNA polymerase II and Epigenetics.
His study in Pathogenesis is interdisciplinary in nature, drawing from both Right ventricular hypertrophy, Pulmonary hypertension, Growth factor, CTGF and Transforming growth factor.
His Cell biology research is multidisciplinary, relying on both KLF2, microRNA and Enos.
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