World's Best Scientists 2026 revealed!
VIEW LIST
John Y.-J. Shyy

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
23337
World Ranking
4074
National Ranking
2003

John Y.-J. Shyy publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where John Y.-J. Shyy sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 200 publications — 50th percentile

50% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

John Y.-J. Shyy D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where John Y.-J. Shyy sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 80 D-Index — 80th percentile

80% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John Y.-J. Shyy is affiliated with the University of California, San Diego in the United States. Their research spans multiple fields, with a significant focus on medicine as well as biochemistry, genetics, and molecular biology.

Their work concentrates on several main topics, including:

  • Pulmonary Hypertension Research and Treatments
  • Kruppel-like factors research
  • MicroRNA in disease regulation
  • Cancer-related molecular mechanisms research
  • Inflammasome and immune disorders
  • RNA modifications and cancer
  • Metabolism, Diabetes, and Cancer

Main subfields of study related to their publications include molecular biology, pulmonary and respiratory medicine, cancer research, cardiology and cardiovascular medicine, and surgery.

John Y.-J. Shyy has published extensively in various scientific venues. The frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation
  • Proceedings of the National Academy of Sciences
  • Arteriosclerosis Thrombosis and Vascular Biology
  • Circulation Research

Among their recent publications are the following papers:

  • "SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2," 2021, Circulation Research
  • "MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension," 2020, Circulation
  • "Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension," 2021, American Journal of Physiology-Cell Physiology
  • "SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions," 2021, Proceedings of the National Academy of Sciences

Collaborations are also a notable aspect of their research output. Frequent co-authors include:

  • Ming He
  • Patricia A. Thistlethwaite
  • Jason X.-J. Yuan
  • Atul Malhotra
  • Pritesh Jain

John Y.-J. Shyy has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2007.

Best Publications

  • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.

    Yu Li;Shanqin Xu;Maria M. Mihaylova;Bin Zheng

  • Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells

    Shu Chien;Song Li;John Y-J. Shyy

  • Role of Integrins in Endothelial Mechanosensing of Shear Stress

    John Y.-J. Shyy;Shu Chien

  • Mechanotransduction in Response to Shear Stress ROLES OF RECEPTOR TYROSINE KINASES, INTEGRINS, AND Shc

    Kuang-Den Chen;Yi-Shuan Li;Michael Kim;Song Li

  • Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands

    Shila Jalali;Miguel A. del Pozo;Kuang-Den Chen;Hui Miao

  • Fluid Shear Stress Activation of Focal Adhesion Kinase LINKING TO MITOGEN-ACTIVATED PROTEIN KINASES

    Song Li;Michael Kim;Ying-Li Hu;Shila Jalali

  • SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.

    Yuyang Lei;Jiao Zhang;Jiao Zhang;Cara R. Schiavon;Ming He

  • Role of integrins in cellular responses to mechanical stress and adhesion

    John Y-J Shyy;Shu Chien

  • MicroRNA-21 targets peroxisome proliferators-activated receptor-α in an autoregulatory loop to modulate flow-induced endothelial inflammation

    Jing Zhou;Kuei Chun Wang;Wei Wu;Shankar Subramaniam

  • DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress.

    Benjamin P C Chen;Yi Shuan Li;Yihua Zhao;Kuang Den Chen

  • Fluorescence Proteins, Live-Cell Imaging, and Mechanobiology: Seeing Is Believing

    Yingxiao Wang;John Y.-J. Shyy;Shu Chien

  • The antiinflammatory effect of laminar flow: The role of PPARγ, epoxyeicosatrienoic acids, and soluble epoxide hydrolase

    Yi Liu;Yingjia Zhang;Kara Schmelzer;Tzong Shyuan Lee

  • Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

    Wei Wu;Han Xiao;Andrés Laguna-Fernandez;Guadalupe Villarreal

  • Simvastatin Induces Heme Oxygenase-1 A Novel Mechanism of Vessel Protection

    Tzong-Shyuan Lee;Chih-Chieh Chang;Yi Zhu;John Y.-J. Shyy

  • AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633.

    Zhen Chen;I-Chen Peng;Wei Sun;Mei I. Su

  • miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4

    Hsin Yi Chen;Yu Min Lin;Yu Min Lin;Hsiang Ching Chung;Hsiang Ching Chung;Yaw Dong Lang

  • Molecular mechanism of endothelial growth arrest by laminar shear stress

    Kurt Lin;Pin Pin Hsu;Benjamin P. Chen;Suli Yuan

  • Nitric Oxide Regulates Monocyte Chemotactic Protein-1

    Philip S. Tsao;Bing Yin Wang;Ricardo Buitrago;John Y.J. Shyy

  • Shear stress induction of the tissue factor gene.

    Ming Chao Lin;Fanny Almus-Jacobs;Hsuan Hsu Chen;Graham C N Parry

  • The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression.

    John Y. J. Shyy;Ming-Chao Lin;Jiahuai Han;Yujuan Lu

Frequent Co-Authors

Shu Chien
Shu Chien University of California, San Diego
Hsien-Da Huang
Hsien-Da Huang Chinese University of Hong Kong, Shenzhen
Shankar Subramaniam
Shankar Subramaniam University of California, San Diego
Tzong-Shyuan Lee
Tzong-Shyuan Lee National Taiwan University
Song Li
Song Li University of California, Los Angeles
Ming-Daw Tsai
Ming-Daw Tsai Academia Sinica
Jason X.-J. Yuan
Jason X.-J. Yuan University of California, San Diego
Atul Malhotra
Atul Malhotra University of California, San Diego
Bruce D. Hammock
Bruce D. Hammock University of California, Davis
Benjamin P C Chen
Benjamin P C Chen The University of Texas Southwestern Medical Center

External Links

Personal website of John Y.-J. Shyy

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Students interested in Biology and Biochemistry have a variety of related online degree options and career pathways to explore. Many roles are available at the intersection of healthcare, data management, and technology.

Emerging fields such as health informatics are seeing rapid growth, and a health information management online degree can provide the skills needed to manage patient data and health systems efficiently. Another popular route is nutrition science; earning an online master's degree in nutrition can open doors to clinical nutrition, public health, and research roles.

Diagnostic technologies are also in demand. Completing your studies at one of the many online ultrasound tech schools can lead to a dynamic career in medical imaging. Those drawn to radiology might pursue online radiology tech programs to qualify for roles in hospitals, clinics, and diagnostic centers.

These diverse programs allow students to tailor their education to fit their interests and the evolving needs of the healthcare sector, all while offering the flexibility of online study.

Best Scientists Citing John Y.-J. Shyy

Shu Chien

Shu Chien

University of California, San Diego

Publications: 104

Bruce D. Hammock

Bruce D. Hammock

University of California, Davis

Publications: 96

Hanjoong Jo

Hanjoong Jo

Emory University

Publications: 60

Benoit Viollet

Benoit Viollet

Institut Cochin

Publications: 60

Christophe Morisseau

Christophe Morisseau

University of California, Davis

Publications: 43

Ingrid Fleming

Ingrid Fleming

Goethe University Frankfurt

Publications: 38

John P. Cooke

John P. Cooke

Houston Methodist

Publications: 36

Martin A. Schwartz

Martin A. Schwartz

Yale University

Publications: 35

Bauer E. Sumpio

Bauer E. Sumpio

Yale University

Publications: 30

Joji Ando

Joji Ando

Dokkyo Medical University

Publications: 29

John D. Imig

John D. Imig

Medical College of Wisconsin

Publications: 29

John R. Falck

John R. Falck

The University of Texas Southwestern Medical Center

Publications: 28

Song Li

Song Li

University of California, Los Angeles

Publications: 27

Marc Foretz

Marc Foretz

Université Paris Cité

Publications: 27

Konstantin G. Birukov

Konstantin G. Birukov

University of Chicago

Publications: 26

Bradford C. Berk

Bradford C. Berk

University of Rochester

Publications: 26

Trending Scientists

Yu-Peng Yuan

Yu-Peng Yuan

Anhui University

Mart C.M. de Jong

Mart C.M. de Jong

Wageningen University & Research

Angela K. Troyer

Angela K. Troyer

University of Toronto

Shannon L. Risacher

Shannon L. Risacher

Indiana University

Vincent Prevot

Vincent Prevot

University of Lille

James A. Rice

James A. Rice

North Carolina State University

Gideon Schreiber

Gideon Schreiber

Weizmann Institute of Science

Motoichiro Kato

Motoichiro Kato

Keio University

Olivier Pironneau

Olivier Pironneau

Sorbonne University

Francis W.H. Yik

Francis W.H. Yik

Hong Kong Polytechnic University

Ilia Polian

Ilia Polian

University of Stuttgart

Andrea Buettner

Andrea Buettner

University of Erlangen-Nuremberg

Ramaswamy Govindan

Ramaswamy Govindan

Washington University in St. Louis

Helen M. Regan

Helen M. Regan

University of California, Riverside

Ilan Alon

Ilan Alon

Ariel University

Mir Behrad Khamesee

Mir Behrad Khamesee

University of Waterloo

Related Biology and Biochemistry Rankings & Guides

2026 Family Nurse Practitioner vs. Psychiatric Mental Health Nurse Practitioner: Explaining the Difference

2026 Family Nurse Practitioner vs. Psychiatric Mental Health Nurse Practitioner: Explaining the Difference
2026 Is a Medical Billing & Coding Online Degree Worth It?

2026 Is a Medical Billing & Coding Online Degree Worth It?
2026 What Prerequisites Do You Need for a Nutrition Degree? Entry Requirements, Credits & Eligibility Rules

2026 What Prerequisites Do You Need for a Nutrition Degree? Entry Requirements, Credits & Eligibility Rules
2026 How Much Does a Nurse Leadership Degree Program Cost? Tuition, Fees & Total Expense Breakdown

2026 How Much Does a Nurse Leadership Degree Program Cost? Tuition, Fees & Total Expense Breakdown
2026 Which Schools Offer Flexible Start-Anytime Enrollment for a Psychiatric Mental Health Nurse Practitioner Program?

2026 Which Schools Offer Flexible Start-Anytime Enrollment for a Psychiatric Mental Health Nurse Practitioner Program?
2026 Military-Friendly Online Exercise Science Degree Programs: Benefits, Accreditation, and Career Outcomes

2026 Military-Friendly Online Exercise Science Degree Programs: Benefits, Accreditation, and Career Outcomes
2026 How to Become a Clinical Research Associate: Education, Salary, and Job Outlook

2026 How to Become a Clinical Research Associate: Education, Salary, and Job Outlook
2026 Different Types of Bioinformatics Degrees and Their Salaries

2026 Different Types of Bioinformatics Degrees and Their Salaries
2026 Certified Nursing Assistant (CNA) vs. Registered Nurse (RN): Explaining the Difference

2026 Certified Nursing Assistant (CNA) vs. Registered Nurse (RN): Explaining the Difference
2026 Cheapest Nutrition and Dietetics Online Degree Programs

2026 Cheapest Nutrition and Dietetics Online Degree Programs
2026 Best Online Bioinformatics Master’s Degree Programs

2026 Best Online Bioinformatics Master’s Degree Programs
2026 Biotechnology Degree vs. Certificate: Which Should You Choose?

2026 Biotechnology Degree vs. Certificate: Which Should You Choose?
2026 Psychiatric Nurse Practitioner vs. Therapist: Explaining the Difference

2026 Psychiatric Nurse Practitioner vs. Therapist: Explaining the Difference
2026 Are Online Radiology Technician Degrees Respected by Employers?

2026 Are Online Radiology Technician Degrees Respected by Employers?
2026 Health Administration Degree vs. Certificate: Which Should You Choose?

2026 Health Administration Degree vs. Certificate: Which Should You Choose?
2026 Online Nutrition Degree Programs for Veterans: GI Bill Benefits, Costs & Top Considerations

2026 Online Nutrition Degree Programs for Veterans: GI Bill Benefits, Costs & Top Considerations
2026 Fastest Online Bioinformatics Master’s Degree Programs

2026 Fastest Online Bioinformatics Master’s Degree Programs
2026 How to Become an Echocardiogram Technician: Education, Salary, and Job Outlook

2026 How to Become an Echocardiogram Technician: Education, Salary, and Job Outlook
2026 Cheapest Online Nurse Executive Leader Master's Degrees That Pay Well: Tuition, Duration, and Earnings

2026 Cheapest Online Nurse Executive Leader Master's Degrees That Pay Well: Tuition, Duration, and Earnings
2026 Easiest Online Healthcare Innovation Master's Degree Programs That Pay Well: High-Salary Degrees with Simple Admissions

2026 Easiest Online Healthcare Innovation Master's Degree Programs That Pay Well: High-Salary Degrees with Simple Admissions
2026 Are Online Biology Degrees Respected by Employers?

2026 Are Online Biology Degrees Respected by Employers?

Recently Published Articles

2026 How to Become a Mental Health Counselor in Houston, TX: Education Requirements & Certification

2026 How to Become a Mental Health Counselor in Houston, TX: Education Requirements & Certification
2026 Best Accelerated Online Bachelor's in Early Childhood Education

2026 Best Accelerated Online Bachelor's in Early Childhood Education
2026 Most In-Demand Bioinformatics Master's Specializations

2026 Most In-Demand Bioinformatics Master's Specializations
2026 Career Outcomes for DSW Graduates (Administration, Policy, Academia)

2026 Career Outcomes for DSW Graduates (Administration, Policy, Academia)
2026 Cheapest and Shortest Online Pharmacy Degree Programs That Pay Well: Cost, Duration, and Salary Outlook

2026 Cheapest and Shortest Online Pharmacy Degree Programs That Pay Well: Cost, Duration, and Salary Outlook
2026 How to Become a Substance Abuse Counselor in New York

2026 How to Become a Substance Abuse Counselor in New York
2026 Online Neuroscience Degrees for EEG Technician Roles

2026 Online Neuroscience Degrees for EEG Technician Roles
2026 Best Medical Assistant Schools & Programs in Minnesota – How to Become a Medical Assistant in Minnesota

2026 Best Medical Assistant Schools & Programs in Minnesota – How to Become a Medical Assistant in Minnesota
2026 Fastest Online Biomedical Engineering Bachelor's Degree Programs You Can Finish in 3 Years or Less

2026 Fastest Online Biomedical Engineering Bachelor's Degree Programs You Can Finish in 3 Years or Less
2026 Best Value Online Gerontology and Aging Master's Degrees: Affordable Accredited Programs with the Highest ROI

2026 Best Value Online Gerontology and Aging Master's Degrees: Affordable Accredited Programs with the Highest ROI
2026 Online Industrial Organizational Psychology Degree Master's Programs That Accept Transfer Credits

2026 Online Industrial Organizational Psychology Degree Master's Programs That Accept Transfer Credits
2026 AI, Automation, and the Future of Disability Studies Degree Careers

2026 AI, Automation, and the Future of Disability Studies Degree Careers
2026 Healthcare Degree Programs You Can Earn in 2 Years or Less

2026 Healthcare Degree Programs You Can Earn in 2 Years or Less
2026 How to Become an LPN in Massachusetts

2026 How to Become an LPN in Massachusetts
2026 Can You Get Into an Art Studies Bachelor's Degree Program with a Low GPA? Admission Chances & Workarounds

2026 Can You Get Into an Art Studies Bachelor's Degree Program with a Low GPA? Admission Chances & Workarounds
2026 State Licensing Differences for Biomedical Engineering Degree Graduates

2026 State Licensing Differences for Biomedical Engineering Degree Graduates
2026 Cheapest Online Business Administration Degrees

2026 Cheapest Online Business Administration Degrees
2026 Which Schools Offer Flexible Start-Anytime Enrollment for a Cybersecurity Program?

2026 Which Schools Offer Flexible Start-Anytime Enrollment for a Cybersecurity Program?
2026 One-Year Online Biology Master's Degree Programs: Accelerated Options, Costs & Outcomes

2026 One-Year Online Biology Master's Degree Programs: Accelerated Options, Costs & Outcomes
2026 Military-Friendly Online Mechanical Engineering Bachelor's Degree Programs

2026 Military-Friendly Online Mechanical Engineering Bachelor's Degree Programs
2026 How to Become a Pharmacy Technician

2026 How to Become a Pharmacy Technician