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Neuroscience

D-Index
32
Citations
4321
World Ranking
9525
National Ranking
4024

Overview

Carl Y. Saab is a researcher affiliated with the Cleveland Clinic in the United States. Their scholarly work primarily spans the fields of Medicine and Neuroscience, with a strong focus on subfields such as Cognitive Neuroscience, Physiology, Anesthesiology and Pain Medicine, Pharmacology, and Psychiatry and Mental Health.

Their research topics cover various aspects of pain and brain function, including:

  • Pain Mechanisms and Treatments
  • EEG and Brain-Computer Interfaces
  • Pain Management and Treatment
  • Musculoskeletal pain and rehabilitation
  • Neural dynamics and brain function
  • Obstructive Sleep Apnea Research
  • Migraine and Headache Studies

Carl Y. Saab has contributed to multiple high-impact papers, including the following recent examples:

  • Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities (2020), published in Nature Reviews Neurology
  • Pain phenotypes classified by machine learning using electroencephalography features (2020), published in NeuroImage
  • Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats (2020), published in Scientific Reports
  • Automated and rapid self-report of nociception in transgenic mice (2020), published in Scientific Reports
  • How quantum computing can enhance biomarker discovery (2025), published in Patterns

The venues frequently chosen for publication by this researcher include:

  • Scientific Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SLEEP
  • Frontiers in Pain Research
  • Nature Reviews Neurology

Co-authorship relationships appear significant in their work, with frequent collaborators including:

  • Reena Mehra
  • David A. Borton
  • Samer Ghosn
  • Muhammad Muzzammil Edhi
  • Matheus Araújo

Best Publications

  • Upregulation of Sodium Channel Nav1.3 and Functional Involvement in Neuronal Hyperexcitability Associated with Central Neuropathic Pain after Spinal Cord Injury

    Bryan C. Hains;Joshua P. Klein;Carl Y. Saab;Matthew J. Craner

  • Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.

    Karen D. Davis;Karen D. Davis;Nima Aghaeepour;Andrew H. Ahn;Martin S. Angst

  • Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury.

    Bryan C. Hains;Carl Y. Saab;Joshua P. Klein;Matthew J. Craner

  • Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury

    Bryan C. Hains;Carl Y. Saab;Stephen G. Waxman

  • Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo.

    Albert C. Lo;Carl Y. Saab;Joel A. Black;Stephen G. Waxman

  • The cerebellum: organization, functions and its role in nociception.

    Carl Y. Saab;William D. Willis

  • Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE

    Joel A. Black;Shujun Liu;Bryan C. Hains;Carl Y. Saab

  • Alterations in Burst Firing of Thalamic VPL Neurons and Reversal by Nav1.3 Antisense After Spinal Cord Injury

    Bryan C. Hains;Carl Y. Saab;Stephen G. Waxman

  • Cortical theta is increased while thalamocortical coherence is decreased in rat models of acute and chronic pain.

    Brian W. LeBlanc;Theresa R. Lii;Andrew E. Silverman;Robert T. Alleyne

  • Preemptive intrathecal ketamine injection produces a long-lasting decrease in neuropathic pain behaviors in a rat model.

    Allen W. Burton;Doo H. Lee;Carl Saab;Jin M. Chung

  • Pain-related changes in the brain: diagnostic and therapeutic potentials

    Carl Y. Saab

  • Sodium channel blockade with phenytoin protects spinal cord axons, enhances axonal conduction, and improves functional motor recovery after contusion SCI.

    Bryan C. Hains;Carl Y. Saab;Albert C. Lo;Stephen G. Waxman

  • Neutrophils invade lumbar dorsal root ganglia after chronic constriction injury of the sciatic nerve.

    N. Morin;S.A. Owolabi;M.W. Harty;E.F. Papa

  • Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn.

    Samuel A. Owolabi;Carl Y. Saab

  • Unilateral focal burn injury is followed by long-lasting bilateral allodynia and neuronal hyperexcitability in spinal cord dorsal horn.

    Yu-Wen Chang;Andrew Tan;Carl Saab;Stephen Waxman

  • High-frequency stimulation in the ventral posterolateral thalamus reverses electrophysiologic changes and hyperalgesia in a rat model of peripheral neuropathic pain.

    Masashi Iwata;Brian W. LeBlanc;Laith M. Kadasi;Michele L. Zerah

  • Electroencephalographic signatures of pain and analgesia in rats.

    Brian W LeBlanc;Paul M Bowary;Paul M Bowary;Yu-Chieh Chao;Yu-Chieh Chao;Yu-Chieh Chao;Theresa R Lii;Theresa R Lii

  • T-type calcium channel blocker Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain.

    Brian W LeBlanc;Theresa R Lii;Jian Jia Huang;Yu-Chieh Chao

  • Minocycline injection in the ventral posterolateral thalamus reverses microglial reactivity and thermal hyperalgesia secondary to sciatic neuropathy.

    Brian W. LeBlanc;Michele L. Zerah;Laith M. Kadasi;Noori Chai

  • Microglia: a newly discovered role in visceral hypersensitivity?

    Carl Y. Saab;Jing Wang;Chunping Gu;Kirsten N. Garner

Frequent Co-Authors

Stephen G. Waxman
Stephen G. Waxman Yale University
Bryan C. Hains
Bryan C. Hains Yale University
Joel A. Black
Joel A. Black Yale University
Sulayman D. Dib-Hajj
Sulayman D. Dib-Hajj Yale University
William D. Willis
William D. Willis The University of Texas Medical Branch at Galveston
Karen D. Davis
Karen D. Davis University Health Network
Jin Mo Chung
Jin Mo Chung The University of Texas Medical Branch at Galveston
Theodore R. Cummins
Theodore R. Cummins Indiana University – Purdue University Indianapolis
Nayef E. Saadé
Nayef E. Saadé American University of Beirut
Takayuki Komatsu
Takayuki Komatsu Nagaoka University of Technology

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