D-Index & Metrics Best Publications
Michael A. Parniak

Michael A. Parniak

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 42 Citations 6,542 84 World Ranking 15501 National Ranking 535

Overview

What is he best known for?

The fields of study he is best known for:

  • DNA
  • Enzyme
  • Gene

His main research concerns Reverse transcriptase, Virology, Molecular biology, Virus and 2'3' dideoxycytidine. His Reverse transcriptase research includes themes of DNA and DNA synthesis. His studies deal with areas such as Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors and Mutant as well as DNA synthesis.

Virology and Mutation are frequently intertwined in his study. His Molecular biology research is multidisciplinary, incorporating elements of Zidovudine, RNA, Transfer RNA, Resistance mutation and Primer. In his study, Genotype and Delavirdine is inextricably linked to Drug resistance, which falls within the broad field of Virus.

His most cited work include:

  • Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. (271 citations)
  • The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine. (205 citations)
  • Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine. (201 citations)

What are the main themes of his work throughout his whole career to date?

Michael A. Parniak mainly focuses on Reverse transcriptase, Virology, Molecular biology, Virus and Primer. His Reverse transcriptase research incorporates themes from Wild type, Mutant, DNA polymerase, Enzyme and DNA synthesis. His study in the fields of Viral replication under the domain of Virology overlaps with other disciplines such as Nevirapine.

His Molecular biology research integrates issues from RNA, Mutation, Biochemistry, DNA and Resistance mutation. His work deals with themes such as Microbicide, In vitro, 2'3' dideoxycytidine and Zalcitabine, which intersect with Virus. His Primer research includes elements of RNA-Directed DNA Polymerase, Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors and Polymerase.

He most often published in these fields:

  • Reverse transcriptase (62.79%)
  • Virology (55.81%)
  • Molecular biology (48.84%)

What were the highlights of his more recent work (between 2000-2014)?

  • Virology (55.81%)
  • Reverse transcriptase (62.79%)
  • Delavirdine (11.63%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Virology, Reverse transcriptase, Delavirdine, Virus and Pharmacology. The various areas that Michael A. Parniak examines in his Virology study include RNA, Terminator and Acquired immunodeficiency syndrome, Sexual transmission. His Reverse transcriptase study combines topics from a wide range of disciplines, such as Molecular biology and Mutant.

His Molecular biology study combines topics in areas such as Primase and DNA, DNA synthesis, DNA polymerase. His research in Delavirdine focuses on subjects like Drug resistance, which are connected to Genotype. His Virus study incorporates themes from Anti hiv 1 and Microbicide.

Between 2000 and 2014, his most popular works were:

  • Genetic Divergence of Human Immunodeficiency Virus Type 1 Ethiopian Clade C Reverse Transcriptase (RT) and Rapid Development of Resistance against Nonnucleoside Inhibitors of RT (115 citations)
  • A Tight-Binding Mode of Inhibition Is Essential for Anti-Human Immunodeficiency Virus Type 1 Virucidal Activity of Nonnucleoside Reverse Transcriptase Inhibitors (61 citations)
  • Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones. (44 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • DNA
  • Gene

Michael A. Parniak mostly deals with Reverse transcriptase, Virus, Virology, Delavirdine and DNA polymerase. His Reverse transcriptase research incorporates elements of Drug resistance and Lentivirus. His work on Multiple drug resistance as part of general Drug resistance research is frequently linked to Silent mutation and Clade, thereby connecting diverse disciplines of science.

His biological study spans a wide range of topics, including Biological activity and Viral load. His studies in DNA polymerase integrate themes in fields like Molecular biology, Mutant, RNase H and Active site. His Molecular biology study integrates concerns from other disciplines, such as Amino acid and Mutagenesis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase.

Dominique Arion;Neerja Kaushik;Suzanne McCormick;Gadi Borkow.
Biochemistry (1998)

486 Citations

Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase.

Mark A. Wainberg;William C. Drosopoulos;Horacio Salomon;Mayla Hsu.
Science (1996)

383 Citations

The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine.

Qing Gao;Zhengxian Gu;M. A. Parniak;J. Cameron.
Antimicrobial Agents and Chemotherapy (1993)

312 Citations

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine.

Zhengxian Gu;Qing Gao;H. Fang;H. Salomon.
Antimicrobial Agents and Chemotherapy (1994)

298 Citations

Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine.

Z Gu;Q Gao;X Li;M A Parniak.
Journal of Virology (1992)

286 Citations

The M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Impairs Rescue of Chain-Terminated DNA Synthesis

Matthias Götte;Dominique Arion;Michael A. Parniak;Mark A. Wainberg;Mark A. Wainberg.
Journal of Virology (2000)

243 Citations

HYBRIDS OF RNA AND ARABINONUCLEIC ACIDS (ANA AND 2'F-ANA) ARE SUBSTRATES OF RIBONUCLEASE H

M. J. Damha;C. J. Wilds;A. Noronha;I. Brukner.
Journal of the American Chemical Society (1998)

222 Citations

In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine.

Qing Gao;Zhengxian Gu;M. A. Parniak;Xuguang Li.
Journal of Virology (1992)

199 Citations

Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris.

Xiao-Jian Yao;Mark A. Wainberg;Mark A. Wainberg;Michael A. Parniak;Michael A. Parniak.
Virology (1992)

165 Citations

Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase.

G Borkow;J Barnard;T M Nguyen;A Belmonte.
Journal of Virology (1997)

162 Citations

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