Michael A. Parniak

Overview

Best Publications

• Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.

  Stefan G. Sarafianos;Bruno Marchand;Kalyan Das;Daniel M. Himmel

  676
  Citations

• Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase.

  Dominique Arion;Neerja Kaushik;Suzanne McCormick;Gadi Borkow

  491
  Citations

• Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase.

  Mark A. Wainberg;William C. Drosopoulos;Horacio Salomon;Mayla Hsu

  401
  Citations

• The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine.

  Qing Gao;Zhengxian Gu;M. A. Parniak;J. Cameron

  326
  Citations

• Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine.

  Zhengxian Gu;Qing Gao;H. Fang;H. Salomon

  309
  Citations

• Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine.

  Z Gu;Q Gao;X Li;M A Parniak

  302
  Citations

• HYBRIDS OF RNA AND ARABINONUCLEIC ACIDS (ANA AND 2'F-ANA) ARE SUBSTRATES OF RIBONUCLEASE H

  M. J. Damha;C. J. Wilds;A. Noronha;I. Brukner

  269
  Citations

• Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

  Scott R. Budihas;Inna Gorshkova;Sergei Gaidamakov;Antony Wamiru

  255
  Citations

• The M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Impairs Rescue of Chain-Terminated DNA Synthesis

  Matthias Götte;Dominique Arion;Michael A. Parniak;Mark A. Wainberg;Mark A. Wainberg

  248
  Citations

• In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine.

  Qing Gao;Zhengxian Gu;M. A. Parniak;Xuguang Li

  201
  Citations

• A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity.

  Michael A Parniak;Kyung-Lyum Min;Scott R Budihas;Stuart F.J Le Grice

  183
  Citations

• HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.

  Daniel M. Himmel;Stefan G. Sarafianos;Stefan G. Sarafianos;Sanjeewa Dharmasena;Mohammed M. Hossain

  175
  Citations

• Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris.

  Xiao-Jian Yao;Mark A. Wainberg;Mark A. Wainberg;Michael A. Parniak;Michael A. Parniak

  173
  Citations

• Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase.

  G Borkow;J Barnard;T M Nguyen;A Belmonte

  162
  Citations

• Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.

  Sanjeev Kumar V. Vernekar;Zheng Liu;Eva Nagy;Lena Miller

  161
  Citations

• Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs).

  N Sluis-Cremer;D Arion;M A Parniak

  157
  Citations

• Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site.

  X Li;Y Quan;E J Arts;Z Li

  156
  Citations

• Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction.

  E. J. Arts;Xuguang Li;Zhengxian Gu;L. Kleiman

  150
  Citations

• Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication.

  Xuguang Li;Johnson Mak;Eric J. Arts;Zhengxian Gu

  150
  Citations

• Genetic Divergence of Human Immunodeficiency Virus Type 1 Ethiopian Clade C Reverse Transcriptase (RT) and Rapid Development of Resistance against Nonnucleoside Inhibitors of RT

  Hugues Loemba;Bluma Brenner;Michael A. Parniak;Shlomo Ma'ayan

  150
  Citations