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Alfred L. M. Bothwell

Alfred L. M. Bothwell

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
14957
World Ranking
7878
National Ranking
3576

Overview

Alfred L. M. Bothwell is affiliated with the University of Arizona in the United States and has contributed extensively to research primarily within the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics, and Molecular Biology. Their work spans several subfields, notably Immunology, Oncology, Molecular Biology, Public Health, Environmental and Occupational Health, and Rheumatology.

The scientist's research focuses on diverse topics including Cancer Cells and Metastasis, Immune Cell Function and Interaction, Cancer Immunotherapy and Biomarkers, Phagocytosis and Immune Regulation, Wnt/β-catenin signaling in development and cancer, Research on Leishmaniasis Studies, and Immunotherapy and Immune Responses.

Notable recent papers authored or coauthored by the scientist include:

  • "Colon cancer cells acquire immune regulatory molecules from tumor-infiltrating lymphocytes by trogocytosis," 2021, Proceedings of the National Academy of Sciences
  • "Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1," 2021, iScience
  • "Trogocytosis-mediated immune evasion in the tumor microenvironment," 2025, Experimental & Molecular Medicine
  • "Dickkopf proteins in pathological inflammatory diseases," 2021, Journal of Leukocyte Biology
  • "Immune cells enhance Zika virus-mediated neurologic dysfunction in brain of mice with humanized immune systems," 2021, Developmental Neurobiology

Frequently collaborating with other researchers, Alfred L. M. Bothwell has repeatedly coauthored work with individuals including Anutr Sivakoses, Stephen E. Maher, Haley Q. Marcarian, Jae Hun Shin, and Olivia C. Ihedioha.

Their research has been published in recurring venues such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, eLife, PLoS ONE, and UNC Libraries, indicating a presence in both preprint repositories and peer-reviewed journals in immunology and related biomedical sciences.

Best Publications

  • Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region.

    Alfred L.M. Bothwell;Michael Paskind;Michael Reth;Thereza Imanishi-Kari

  • Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends.

    Frederick W. Alt;Alfred L.M. Bothwell;Michael Knapp;Edward Siden

  • STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.

    Thomas Welte;Samuel S.M. Zhang;Tian Wang;Zhiyuan Zhang

  • T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity

    Maripat Corr;Alfred E. Slanetz;Lisa F. Boyd;Marie T. Jelonek

  • In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse.

    J. S. Schechner;A. K. Nath;L. Zheng;M. S. Kluger

  • An autoantibody to single‐stranded DNA: Comparison of the three‐dimensional structures of the unliganded fab and a deoxynucleotide–fab complex

    J. N. Herron;X. M. He;D. W. Ballard;P. R. Blier

  • Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28.

    Allen G. Murray;Mehran M. Khodedoust;Jordan S. Pober;Alfred L.M. Bothwell

  • Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation

    Jyoti Das;Guangwen Ren;Liying Zhang;Arthur I. Roberts

  • Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain

    Frederick W. Alt;Vincenzo Enea;Alfred L.M. Bothwell;David Baltimore

  • Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis

    Wook-Jin Chae;Thomas F. Gibson;Daniel Zelterman;Liming Hao

  • Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59

    William C. Hahn;Elisabeth Menu;Alfred L. M. Bothwell;Peter J. Sims

  • Interplay between DNA repair and inflammation, and the link to cancer

    Dawit Kidane;Wook Jin Chae;Jennifer Czochor;Kristin A Eckert

  • Pax5 is required for recombination of transcribed, acetylated, 5′ IgH V gene segments

    David G.T. Hesslein;David L. Pflugh;Dipanjan Chowdhury;Alfred L. M. Bothwell

  • Lateral diffusion of membrane-spanning and glycosylphosphatidylinositol-linked proteins: toward establishing rules governing the lateral mobility of membrane proteins.

    Fen Zhang;B. Crise;Bing Su;Y. Hou

  • The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases.

    Je-Min Choi;Alfred L. M. Bothwell

  • Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.

    B. K. Al-Ramadi;M. T. Jelonek;L. F. Boyd;D. H. Margulies

  • Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds.

    Khuda Dad Khan;Ke Shuai;Glen Lindwall;Stephen E. Maher

  • Molecular basis of a mouse strain-specific anti-hapten response

    Dennis Y. Loh;Alfred L.M. Bothwell;Mary E. White-Scharf;Thereza Imanishi-Kari

  • Somatic variants of murine immunoglobulin lambda light chains.

    Alfred L. M. Bothwell;Michael Paskind;Michael Reth;Thereza Imanishi-Kari

  • Nucleotide sequence and in vitro processing of a precursor molecule to Escherichia coli 4.5 S RNA

    A. L.M. Bothwell;R. L. Garber;S. Altman

Frequent Co-Authors

Jordan S. Pober
Jordan S. Pober Yale University
Peter J. Sims
Peter J. Sims University of Rochester
David Baltimore
David Baltimore California Institute of Technology
Sidney Altman
Sidney Altman Yale University
James F. Leckman
James F. Leckman Yale University
David G. Schatz
David G. Schatz Yale University
Dean W. Ballard
Dean W. Ballard Vanderbilt University
Yufang Shi
Yufang Shi Soochow University
Bing Su
Bing Su Shanghai Jiao Tong University
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital

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