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Molecular Biology

D-Index
66
Citations
19623
World Ranking
1609
National Ranking
815

Overview

Deborah L. Croteau is affiliated with the National Institutes of Health in the United States and has contributed extensively to research in the fields of biochemistry, genetics, molecular biology, and medicine. Their work largely focuses on molecular biology aspects of aging and disease mechanisms.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, Croteau has specialized in several subfields such as:

  • Molecular Biology
  • Physiology
  • Epidemiology
  • Immunology
  • Sensory Systems

The core topics of their research portfolio cover:

  • DNA Repair Mechanisms
  • Mitochondrial Function and Pathology
  • Autophagy in Disease and Therapy
  • Sirtuins and Resveratrol in Medicine
  • Calcium signaling and nucleotide metabolism
  • Interferon and immune responses
  • Alzheimer's disease research and treatments

Deborah L. Croteau's recent peer-reviewed papers include:

  • NAD + supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING, 2021, Proceedings of the National Academy of Sciences
  • Olfactory dysfunction in aging and neurodegenerative diseases, 2021, Ageing Research Reviews
  • Heterochromatin: an epigenetic point of view in aging, 2020, Experimental & Molecular Medicine
  • Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease, 2020, iScience
  • DNA damage and mitochondria in cancer and aging, 2020, Carcinogenesis

The venues where Croteau publishes frequently include:

  • Aging Cell
  • Nucleic Acids Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Experimental & Molecular Medicine
  • Frontiers in Aging Neuroscience

Frequent collaborators in research efforts include:

  • Vilhelm A. Bohr
  • Mansoor Hussain
  • Beimeng Yang
  • Yujun Hou
  • Jae Hyeon Park

Best Publications

  • Ageing as a risk factor for neurodegenerative disease.

    Yujun Hou;Xiuli Dan;Mansi Babbar;Yong Wei

  • Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

    E F Fang;Y Hou;K Palikaras;B A Adriaanse

  • REPAIR OF OXIDATIVE DAMAGE TO NUCLEAR AND MITOCHONDRIAL DNA IN MAMMALIAN CELLS

    Deborah L. Croteau;Vilhelm A. Bohr

  • Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

    Evandro Fei Fang;Morten Scheibye-Knudsen;Lear E. Brace;Henok Kassahun

  • Human RecQ helicases in DNA repair, recombination, and replication.

    Deborah L. Croteau;Venkateswarlu Popuri;Patricia L. Opresko;Vilhelm A. Bohr

  • NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

    Evandro Fei Fang;Henok Kassahun;Deborah L. Croteau;Morten Scheibye-Knudsen;Morten Scheibye-Knudsen

  • NAD+ in Aging: Molecular Mechanisms and Translational Implications

    Evandro Fei Fang;Evandro Fei Fang;Sofie Lautrup;Sofie Lautrup;Yujun Hou;Tyler G Demarest

  • Prokaryotic nucleotide excision repair: the UvrABC system.

    James J. Truglio;Deborah L. Croteau;Bennett Van Houten;Caroline Kisker

  • DNA Damage, DNA Repair, Aging, and Neurodegeneration

    Scott Maynard;Evandro Fei Fang;Morten Scheibye-Knudsen;Deborah L. Croteau

  • NAD + supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

    Yujun Hou;Sofie Lautrup;Sofie Lautrup;Stephanie Cordonnier;Yue Wang

  • Nuclear DNA damage signalling to mitochondria in ageing

    Evandro Fei Fang;Morten Scheibye-Knudsen;Katrin F. Chua;Mark P. Mattson

  • A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

    Morten Scheibye-Knudsen;Sarah J. Mitchell;Sarah J. Mitchell;Evandro F. Fang;Teruaki Iyama

  • Mitochondrial DNA repair pathways.

    Deborah L Croteau;Rob.H Stierum;Vilhelm A Bohr

  • Protecting the mitochondrial powerhouse.

    Morten Scheibye-Knudsen;Evandro F. Fang;Deborah L. Croteau;David M. Wilson

  • NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.

    Yujun Hou;Yujun Hou;Yong Wei;Yong Wei;Sofie Lautrup;Sofie Lautrup;Beimeng Yang

  • Cockayne syndrome: Clinical features, model systems and pathways

    Ajoy C. Karikkineth;Morten Scheibye-Knudsen;Elayne Fivenson;Deborah L. Croteau

  • Crystal Structure of the FeS Cluster–Containing Nucleotide Excision Repair Helicase XPD

    Stefanie C Wolski;Jochen Kuper;Petra Hänzelmann;James J Truglio

  • Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

    Morten Scheibye-Knudsen;Mahesh Ramamoorthy;Peter Sykora;Scott Maynard

  • An Oxidative Damage-specific Endonuclease from Rat Liver Mitochondria

    Deborah L. Croteau;Deborah L. Croteau;Colette M.J. ap Rhys;Edgar K. Hudson;Grigory L. Dianov

  • NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.

    Evandro F. Fang;Yujun Hou;Sofie Lautrup;Martin Borch Jensen

Frequent Co-Authors

Vilhelm A. Bohr
Vilhelm A. Bohr University of Copenhagen
Bennett Van Houten
Bennett Van Houten University of Pittsburgh
Mark P. Mattson
Mark P. Mattson Johns Hopkins University
Caroline Kisker
Caroline Kisker University of Würzburg
David M. Wilson
David M. Wilson AstraZeneca (United Kingdom)
Nadja C. de Souza-Pinto
Nadja C. de Souza-Pinto Universidade de São Paulo
Kevin G. Becker
Kevin G. Becker National Institutes of Health
Dorothy A. Erie
Dorothy A. Erie University of North Carolina at Chapel Hill
Robert M. Brosh
Robert M. Brosh National Institutes of Health
Ian O. Ellis
Ian O. Ellis University of Nottingham

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