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Chemistry

D-Index
62
Citations
13871
World Ranking
8810
National Ranking
235

Overview

Giovanni Natile is affiliated with the University of Bari Aldo Moro in Italy. Their research primarily spans the fields of Medicine and Chemistry, with a particular focus on Oncology and Organic Chemistry. Additional subfields include Materials Chemistry, Nutrition and Dietetics, and Molecular Biology.

The scientist's work addresses several main topics, including:

  • Metal complexes synthesis and properties
  • Ferrocene Chemistry and Applications
  • Trace Elements in Health
  • Drug Transport and Resistance Mechanisms
  • Lanthanide and Transition Metal Complexes
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography

Publications by Giovanni Natile have appeared repeatedly in journals such as:

  • International Journal of Molecular Sciences (3 papers)
  • Dalton Transactions (2 papers)
  • The Cambridge Structural Database (2 papers)
  • Seminars in Cancer Biology (1 paper)
  • Angewandte Chemie International Edition (1 paper)

Recent notable papers include:

  • Interference between copper transport systems and platinum drugs, 2021, Seminars in Cancer Biology
  • 19F NMR Allows the Investigation of the Fate of Platinum(IV) Prodrugs in Physiological Conditions, 2021, Angewandte Chemie International Edition
  • Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance, 2020, International Journal of Molecular Sciences
  • Multinuclear Metal-Binding Ability of the N-Terminal Region of Human Copper Transporter Ctr1: Dependence Upon pH and Metal Oxidation State, 2022, Frontiers in Molecular Biosciences
  • Improvement of Kiteplatin Efficacy by a Benzoato Pt(IV) Prodrug Suitable for Oral Administration, 2022, International Journal of Molecular Sciences

Frequent collaborators include Nicola Margiotta, Fabio Arnesano, Alessandra Barbanente, Concetta Pacifico, and James D. Hoeschele. These coauthors have contributed to multiple joint publications, indicating ongoing research partnerships.

Best Publications

  • Hydrophobic Nanocrystals Coated with an Amphiphilic Polymer Shell: A General Route to Water Soluble Nanocrystals

    Teresa Pellegrino;Liberato Manna;Stefan Kudera;Tim Liedl

  • Biomimetic Hydroxyapatite–Drug Nanocrystals as Potential Bone Substitutes with Antitumor Drug Delivery Properties†

    Barbara Palazzo;Michele Iafisco;Mariarita Laforgia;Nicola Margiotta

  • Mechanistic insight into the cellular uptake and processing of cisplatin 30 years after its approval by FDA

    Fabio Arnesano;Giovanni Natile

  • Current status of trans-platinum compounds in cancer therapy

    Giovanni Natile;Mauro Coluccia

  • A trans-platinum complex showing higher antitumor activity than the cis congeners.

    Mauro Coluccia;Anna Nassi;Francesco Loseto;Angela Boccarelli

  • Trans-Platinum Complexes in Cancer Therapy

    Mauro Coluccia;Giovanni Natile

  • Probing the interaction of cisplatin with the human copper chaperone Atox1 by solution and in-cell NMR spectroscopy.

    Fabio Arnesano;Lucia Banci;Ivano Bertini;Isabella C. Felli

  • Mechanistic and Stereochemical Investigation of Imino Ethers Formed by Alcoholysis of Coordinated Nitriles: X-ray Crystal Structures of cis- and trans-Bis(1-imino-1-methoxyethane)dichloroplatinum(II)

    Renzo Cini;Paola A. Caputo;Francesco P. Intini;Giovanni Natile

  • Five-coordinate alkene complexes of palladium(II) and platinum(II)

    Vincenzo G. Albano;Giovanni Natile;Achille Panunzi

  • Interaction between platinum complexes and a methionine motif found in copper transport proteins.

    Fabio Arnesano;Simone Scintilla;Giovanni Natile

  • DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes

    Olga Novakova;Jana Kasparkova;Jaroslav Malina;Giovanni Natile

  • Platinum amides from platinum nitriles: x-ray crystal structures of the unbridged dinuclear compounds bis[bis(1-imino-1-hydroxy-2,2-dimethylpropane)dichloroplatinum(II)] and bis[bis(1-imino-1-hydroxy-2,2-dimethylpropane)(1-amino-1-oxo-2,2-dimethylpropane)dichloroplatinum(II)]

    Renzo Cini;Francesco P. Fanizzi;Francesco P. Intini;Luciana Maresca

  • Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand.

    Jana Kasparkova;Marie Vojtiskova;Giovanni Natile;Viktor Brabec

  • PLATINUM(II) COMPLEXES CONTAINING IMINOETHERS : A TRANS PLATINUM ANTITUMOUR AGENT

    Mauro Coluccia;Angelina Boccarelli;Maria Addolorata Mariggio;N Cardellicchio

  • DNA adducts of antitumor trans-[PtCl2(E-imino ether)2]

    Viktor Brabec;Oldrich Vrána;Olga Nováková;Vladimír Kleinwächter

  • Smart delivery of antitumoral platinum complexes from biomimetic hydroxyapatite nanocrystals

    Michele Iafisco;Michele Iafisco;Barbara Palazzo;Barbara Palazzo;Marco Marchetti;Nicola Margiotta

  • Translocation of Platinum Anticancer Drugs by Human Copper ATPases ATP7A and ATP7B

    Francesco Tadini-Buoninsegni;Gianluca Bartolommei;Maria Rosa Moncelli;Giuseppe Inesi

  • New Concepts Relevant to Cisplatin Anticancer Activity from Unique Spectral Features Providing Evidence That Adjacent Guanines in d(GpG), Intrastrand-Cross-Linked at N7 by a cis-Platinum(II) Moiety, Can Adopt a Head-to-Tail Arrangement

    Luigi G. Marzilli;Susan O. Ano;Francesco P. Intini;Giovanni Natile

  • High resolution proton MR spectroscopy of cerebrospinal fluid in MS patients. Comparison with biochemical changes in demyelinating plaques

    Isabella Laura Simone;Francesco Federico;Maria Trojano;Carla Tortorella

  • Reaction of Zn7metallothionein with cis- and trans-[Pt(N-donor)2Cl2] anticancer complexes: trans-Pt(II) complexes retain their N-donor ligands.

    Markus Knipp;Andrei V Karotki;Serge Chesnov;Giovanni Natile

  • Nucleophilic attack of amine and hydroxide to platinum dibenzonitrile dichloride. Crystal structure of [Pt(NH:CPhN-tert-BuCH2CH2NH-tert-Bu)Cl(NHCOPh)] and cis-[PtNH:CPhN-tert-BuCH2CH2NH-tert-Bu)Cl2(NCPh)]

    Luciana. Maresca;Giovanni. Natile;Francesco P. Intini;Francesco. Gasparrini

Frequent Co-Authors

Francesco P. Fanizzi
Francesco P. Fanizzi University of Salento
Francesco Gasparrini
Francesco Gasparrini Sapienza University of Rome
Antonio Tiripicchio
Antonio Tiripicchio University of Parma
Luigi G. Marzilli
Luigi G. Marzilli Louisiana State University
Viktor Brabec
Viktor Brabec Czech Academy of Sciences
Jana Kasparkova
Jana Kasparkova Czech Academy of Sciences
Valentina Gandin
Valentina Gandin University of Padua
Cristina Marzano
Cristina Marzano University of Padua
Robin J. H. Clark
Robin J. H. Clark University College London
Michele Iafisco
Michele Iafisco National Research Council (CNR)

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