World's Best Scientists 2026 revealed!
Richard A. Friesner

Richard A. Friesner

D-Index & Metrics

Chemistry

D-Index
117
Citations
90276
World Ranking
548
National Ranking
233

Research.com Recognitions

  • 2016 - Member of the National Academy of Sciences
  • 2008 - Fellow of the American Academy of Arts and Sciences
  • 1984 - Fellow of Alfred P. Sloan Foundation

Overview

Richard A. Friesner is affiliated with Columbia University in the United States. Their research spans multiple scientific disciplines, primarily focusing on Biochemistry, Genetics and Molecular Biology, Physics and Astronomy, and Materials Science. Within these areas, Friesner has contributed extensively to subfields such as Molecular Biology, Atomic and Molecular Physics and Optics, Materials Chemistry, Spectroscopy, and Computational Theory and Mathematics.

The scientist's work emphasizes several key topics, including:

  • Advanced Chemical Physics Studies
  • Protein Structure and Dynamics
  • Machine Learning in Materials Science
  • Computational Drug Discovery Methods
  • SARS-CoV-2 and COVID-19 Research
  • Catalysis and Oxidation Reactions
  • Advanced NMR Techniques and Applications

Friesner has published consistently in several prominent venues, with the most frequent publication outlets being:

  • Journal of Chemical Theory and Computation
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Chemical Physics
  • arXiv (Cornell University)
  • Journal of Molecular Biology

Their recent papers include the following:

  • OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space (2021), Journal of Chemical Theory and Computation
  • Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains (2020), Cell Host & Microbe
  • Reliable and Accurate Solution to the Induced Fit Docking Problem for Protein-Ligand Binding (2021), Journal of Chemical Theory and Computation
  • Enhancing Hit Discovery in Virtual Screening through Absolute Protein-Ligand Binding Free-Energy Calculations (2023), Journal of Chemical Information and Modeling
  • High-Dimensional Neural Network Potential for Liquid Electrolyte Simulations (2022), The Journal of Physical Chemistry B

Frequent co-authors collaborating with Friesner include:

  • David R. Reichman
  • John L. Weber
  • James Shee
  • Jared M. Sampson
  • Lingle Wang

Richard A. Friesner's contributions have been recognized with awards such as:

  • Member of the National Academy of Sciences (2016)
  • Fellow of the American Academy of Arts and Sciences (2008)
  • Fellow of Alfred P. Sloan Foundation (1984)

Best Publications

  • Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy.

    Richard A Friesner;Jay L Banks;Robert B Murphy;Thomas A Halgren

  • Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein-Ligand Complexes

    Richard A. Friesner;Robert B. Murphy;Matthew P. Repasky;Leah L. Frye

  • Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening.

    Thomas A. Halgren;Robert B. Murphy;Richard A. Friesner;Hege S. Beard

  • Evaluation and Reparametrization of the OPLS-AA Force Field for Proteins via Comparison with Accurate Quantum Chemical Calculations on Peptides†

    George A. Kaminski and;Richard A. Friesner;Julian Tirado-Rives and;William L. Jorgensen

  • OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

    Edward Harder;Wolfgang Damm;Jon Maple;Chuanjie Wu

  • A hierarchical approach to all-atom protein loop prediction.

    Matthew P. Jacobson;David L. Pincus;Chaya S. Rapp;Tyler J.F. Day

  • Novel procedure for modeling ligand/receptor induced fit effects.

    Woody Sherman;Tyler Day;Matthew P Jacobson;Richard A Friesner

  • Jaguar: A high-performance quantum chemistry software program with strengths in life and materials sciences

    Art D. Bochevarov;Edward Harder;Thomas F. Hughes;Jeremy R. Greenwood

  • OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space.

    Chao Lu;Chuanjie Wu;Delaram Ghoreishi;Wei Chen

  • Integrated Modeling Program, Applied Chemical Theory (IMPACT).

    Jay L. Banks;Hege S. Beard;Yixiang X. Cao;Art E. Cho

  • On the role of the crystal environment in determining protein side-chain conformations.

    Matthew P. Jacobson;Richard A. Friesner;Zhexin Xiang;Barry Honig

  • Accurate and Reliable Prediction of Relative Ligand Binding Potency in Prospective Drug Discovery by Way of a Modern Free-Energy Calculation Protocol and Force Field

    Lingle Wang;Yujie Wu;Yuqing Deng;Byungchan Kim

  • PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results

    Steven L. Dixon;Alexander M. Smondyrev;Eric H. Knoll;Eric H. Knoll;Shashidhar N. Rao

  • A comparison of different propagation schemes for the time dependent Schro¨dinger equation

    C. Leforestier;R. H. Bisseling;C. Cerjan;M. D. Feit

  • Accurate First Principles Calculation of Molecular Charge Distributions and Solvation Energies from Ab Initio Quantum Mechanics and Continuum Dielectric Theory

    David J. Tannor;Bryan Marten;Robert Murphy;Richard A. Friesner

  • OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules.

    Katarina Roos;Chuanjie Wu;Wolfgang Damm;Mark Reboul

  • New Model for Calculation of Solvation Free Energies: Correction of Self-Consistent Reaction Field Continuum Dielectric Theory for Short-Range Hydrogen-Bonding Effects

    Bryan Marten;Kyungsun Kim;Christian Cortis,‖,⊥ and;Richard A. Friesner

  • The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling

    Jianing Li;Robert Abel;Kai Zhu;Yixiang Cao

  • Replica exchange with solute tempering: a method for sampling biological systems in explicit water.

    Pu Liu;Byungchan Kim;Richard A. Friesner;B. J. Berne

  • Replica Exchange with Solute Scaling: A more efficient version of Replica Exchange with Solute Tempering (REST2)

    Lingle Wang;Richard A. Friesner;B. J. Berne

  • Motifs for molecular recognition exploiting hydrophobic enclosure in protein–ligand binding

    Tom Young;Robert Abel;Byungchan Kim;Bruce J. Berne

  • Role of the Active-Site Solvent in the Thermodynamics of Factor Xa Ligand Binding

    Robert Abel;Tom Young;Ramy Farid;Bruce J. Berne

Frequent Co-Authors

Bruce J. Berne
Bruce J. Berne Columbia University
Mu-Hyun Baik
Mu-Hyun Baik Korea Advanced Institute of Science and Technology
Victor Guallar
Victor Guallar Barcelona Supercomputing Center
Matthew P. Jacobson
Matthew P. Jacobson University of California, San Francisco
Ronald M. Levy
Ronald M. Levy Temple University
David R. Reichman
David R. Reichman Columbia University
Kenneth Sauer
Kenneth Sauer Lawrence Berkeley National Laboratory
Woody Sherman
Woody Sherman Psivant Therapeutics
Louis E. Brus
Louis E. Brus Columbia University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Chemistry in the USA opens doors to several related online degrees and career options. For those considering a foundation in science with practical application, an accredited online criminal justice associate degree might seem unrelated at first, but it offers pathways into forensic chemistry within law enforcement agencies.

Alternatively, students can choose to specialize with a paralegal associate degree, which pairs knowledge of chemistry with legal expertise, supporting patent law, environmental regulations, or chemical compliance cases.

Graduates focusing on the pharmaceutical sector may explore careers as pharmaceutical sales representatives. Understanding the science behind drugs enhances performance in this role, which makes pursuing a career guided by insights into pharma sales rep salary and career paths valuable for planning.

For those committed to clinical science and patient care, becoming a pharmacist remains a prestigious goal. Reviewing the pharmacist education requirements is essential, as this career demands advanced degrees and licensure but offers a rewarding professional trajectory integrating chemistry expertise.

Best Scientists Citing Richard A. Friesner

Trending Scientists