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Biology and Biochemistry

D-Index
60
Citations
15324
World Ranking
11818
National Ranking
909

Overview

Karen A. Lillycrop is affiliated with the University of Southampton in the United Kingdom. Their research primarily spans medicine and biochemistry, genetics, and molecular biology. Within these fields, their focus extends into several subfields, including molecular biology, pediatrics, perinatology and child health, physiology, nutrition and dietetics, and obstetrics and gynecology.

Their work covers key topics centered on epigenetics and DNA methylation, birth, development, and health, fatty acid research and health, gestational diabetes research and management, pregnancy and preeclampsia studies, nutrition and health in aging, and adipose tissue and metabolism.

Frequent publication venues for their research include Frontiers in Immunology, Proceedings of The Nutrition Society, Epigenetics, Scientific Reports, and Journal of Cachexia Sarcopenia and Muscle.

Among their recent papers are:

  • "Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial," 2020, PLoS Medicine
  • "Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia," 2024, Nature Metabolism
  • "Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults," 2020, Environmental Health Perspectives
  • "Myo-Inositol, Probiotics, and Micronutrient Supplementation From Preconception for Glycemia in Pregnancy: NiPPeR International Multicenter Double-Blind Randomized Controlled Trial," 2021, Diabetes Care
  • "Modification of subcutaneous white adipose tissue inflammation by omega-3 fatty acids is limited in human obesity-a double blind, randomised clinical trial," 2022, EBioMedicine

The scholar often collaborates with researchers including Keith M. Godfrey, Elie Antoun, Graham C. Burdge, Philip C. Calder, and Mark A. Burton.

Best Publications

  • Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring

    Karen A. Lillycrop;Emma S. Phillips;Alan A. Jackson;Mark A. Hanson

  • Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity

    Keith M. Godfrey;Allan M Sheppard;Peter D. Gluckman;Karen A. Lillycrop

  • Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications

    Karen A. Lillycrop;Jo L. Slater-Jefferies;Mark A. Hanson;Keith M. Godfrey

  • Child health, developmental plasticity, and epigenetic programming.

    Z. Hochberg;Robert Feil;M. Constancia;M. Fraga

  • Epigenetic Mechanisms and the Mismatch Concept of the Developmental Origins of Health and Disease

    Keith M Godfrey;Karen A Lillycrop;Graham C Burdge;Peter D Gluckman

  • Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARα promoter of the offspring

    Karen A. Lillycrop;Emma S. Phillips;Christopher Torrens;Mark A. Hanson

  • Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations.

    Graham C. Burdge;Jo Slater-Jefferies;Christopher Torrens;Emma S. Phillips

  • Nutrition, epigenetics, and developmental plasticity: implications for understanding human disease.

    Graham C. Burdge;Karen A. Lillycrop

  • Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?

    Graham C Burdge;Mark A Hanson;Jo L Slater-Jefferies;Karen A Lillycrop

  • Metabolic plasticity during mammalian development is directionally dependent on early nutritional status

    Peter D. Gluckman;Karen A. Lillycrop;Mark H. Vickers;Anthony B. Pleasants

  • Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms.

    Mark Hanson;Keith M. Godfrey;Karen A. Lillycrop;Graham C. Burdge

  • Epigenetic changes in early life and future risk of obesity.

    Karen A. Lillycrop;Graham C. Burdge

  • Folic Acid Supplementation during the Juvenile-Pubertal Period in Rats Modifies the Phenotype and Epigenotype Induced by Prenatal Nutrition

    Graham C. Burdge;Karen A. Lillycrop;Emma S. Phillips;Joanne L. Slater-Jefferies

  • Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript.

    J C Zwaagstra;H Ghiasi;S M Slanina;A B Nesburn

  • Mitochondrial Oxidative Capacity and NAD + Biosynthesis are Reduced in Human Sarcopenia across Ethnicities

    Eugenia Migliavacca;Stacey K. H. Tay;Harnish P. Patel;Harnish P. Patel;Tanja Sonntag;Tanja Sonntag

  • Predicting Later-Life Outcomes of Early-Life Exposures

    Kim Boekelheide;Bruce Blumberg;Robert E. Chapin;Ila Cote

  • Epigenetic mechanisms linking early nutrition to long term health

    Karen A. Lillycrop;Graham C. Burdge

  • The octamer-binding protein Oct-2 represses HSV immediate-early genes in cell lines derived from latently infectable sensory neurons.

    K.A. Lillycrop;C.L. Dent;S.C. Wheatley;M.N. Beech

  • A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells

    K.A. Lillycrop;V.S. Budrahan;N.D. Lakin;G. Terrenghi

  • An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth

    Amanda J. Drake;Rhoanne C. McPherson;Keith M. Godfrey;Keith M. Godfrey;Cyrus Cooper

Frequent Co-Authors

Mark A. Hanson
Mark A. Hanson University of Southampton
Keith M. Godfrey
Keith M. Godfrey University of Southampton
Cyrus Cooper
Cyrus Cooper University of Southampton
Peter D. Gluckman
Peter D. Gluckman University of Auckland
Hazel Inskip
Hazel Inskip University of Southampton
Philip C. Calder
Philip C. Calder University of Southampton
Nicholas C. Harvey
Nicholas C. Harvey University of Southampton
Elizabeth A. Miles
Elizabeth A. Miles University of Southampton
Johnathan A. Napier
Johnathan A. Napier Rothamsted Research
Jeffrey M. Craig
Jeffrey M. Craig Deakin University

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