World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
8559
World Ranking
18371
National Ranking
223

Overview

Dong-Yup Lee is affiliated with Sungkyunkwan University in South Korea and has contributed extensively to the field of Biochemistry, Genetics, and Molecular Biology. Their research primarily spans molecular biology, biomedical engineering, physical and theoretical chemistry, plant science, and genetics. Lee's work represents a significant focus on understanding complex biological systems through molecular and engineering approaches.

The main topics of Dong-Yup Lee's research include:

  • Viral Infectious Diseases and Gene Expression in Insects
  • Microbial Metabolic Engineering and Bioproduction
  • Protein purification and stability
  • Gut microbiota and health
  • Thermodynamics and calorimetric analyses
  • Biofuel production and bioconversion
  • Gene Regulatory Network Analysis

Lee has published multiple papers, contributing to several key journals in biotechnology and metabolic engineering. Some notable recent papers include:

  • MEMOTE for standardized genome-scale metabolic model testing, 2020, Nature Biotechnology
  • What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines, 2020, Metabolic Engineering
  • Enzyme capacity-based genome scale modelling of CHO cells, 2020, Metabolic Engineering
  • Bioprocess digital twins of mammalian cell culture for advanced biomanufacturing, 2021, Current Opinion in Chemical Engineering
  • Combination of red and blue light induces anthocyanin and other secondary metabolite biosynthesis pathways in an age-dependent manner in Batavia lettuce, 2021, Plant Science

Frequent coauthors collaborating with Lee include:

  • Seo-Young Park
  • Meiyappan Lakshmanan
  • Yi Qing Lee
  • Dong-Hyuk Choi
  • Lokanand Koduru

Their publications are commonly found in journals such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biotechnology and Bioengineering
  • Metabolic Engineering
  • Applied Microbiology and Biotechnology
  • Frontiers in Microbiology

Lee's research draws on a multidisciplinary approach that integrates biochemical and molecular biology techniques with engineering principles. Their work in microbial metabolic engineering and bioproduction intersects with broader themes in health and energy, including biofuel production and gut microbiota analysis.

Overall, Dong-Yup Lee is involved in advancing understanding across several interconnected fields, often collaborating with a core group of coauthors and contributing to a significant number of publications in both peer-reviewed journals and preprint archives.

Best Publications

  • MEMOTE for standardized genome-scale metabolic model testing

    Christian Lieven;Moritz Emanuel Beber;Brett G. Olivier;Frank T. Bergmann

  • Systems biotechnology for strain improvement

    Sang Yup Lee;Dong-Yup Lee;Tae Yong Kim

  • Metabolic Engineering of Escherichia coli for Enhanced Production of Succinic Acid, Based on Genome Comparison and In Silico Gene Knockout Simulation

    Sang Jun Lee;Dong-Yup Lee;Tae Yong Kim;Byung Hun Kim

  • Recon 2.2: from reconstruction to model of human metabolism

    Neil Swainston;Kieran Smallbone;Hooman Hefzi;Paul D. Dobson

  • Synthetic fusion protein design and applications.

    Kai Yu;Chengcheng Liu;Byung-Gee Kim;Dong-Yup Lee;Dong-Yup Lee

  • A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.

    Hooman Hefzi;Kok Siong Ang;Michael Hanscho;Aarash Bordbar

  • Combined in silico modeling and metabolomics analysis to characterize fed‐batch CHO cell culture

    Suresh Selvarasu;Ying Swan Ho;William P. K. Chong;Niki S. C. Wong

  • Genome and evolution of the shade-requiring medicinal herb Panax ginseng.

    Nam Hoon Kim;Murukarthick Jayakodi;Sang Choon Lee;Beom Soon Choi

  • Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement

    Bevan Ks Chung;Bevan Ks Chung;Suresh Selvarasu;Andrea Camattari;Jimyoung Ryu

  • Metabolite essentiality elucidates robustness of Escherichia coli metabolism

    Pan-Jun Kim;Dong-Yup Lee;Tae Yong Kim;Kwang Ho Lee

  • MetaFluxNet: the management of metabolic reaction information and quantitative metabolic flux analysis

    Dong-Yup Lee;Hongsoek Yun;Sunwon Park;Sang Yup Lee

  • N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies

    Sha Sha;Cyrus Agarabi;Kurt Brorson;Dong-Yup Lee

  • Codon Optimization OnLine (COOL): a web-based multi-objective optimization platform for synthetic gene design

    Ju Xin Chin;Bevan Kai-Sheng Chung;Dong-Yup Lee

  • Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II.

    William P.K. Chong;Satty G. Reddy;Faraaz N.K. Yusufi;Dong-Yup Lee;Dong-Yup Lee

  • Computational codon optimization of synthetic gene for protein expression

    Bevan Kai-Sheng Chung;Bevan Kai-Sheng Chung;Dong-Yup Lee;Dong-Yup Lee

  • LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells.

    William Pooi Kat Chong;Shu Hui Thng;Ai Ping Hiu;Dong-Yup Lee;Dong-Yup Lee

  • Software applications for flux balance analysis

    Meiyappan Lakshmanan;Geoffrey Koh;Bevan K.S. Chung;Dong-Yup Lee

  • Genome-scale modeling and in silico analysis of ethanologenic bacteria Zymomonas mobilis.

    Hanifah Widiastuti;Jae Young Kim;Suresh Selvarasu;Iftekhar A. Karimi

  • Mammalian Systems Biotechnology Reveals Global Cellular Adaptations in a Recombinant CHO Cell Line

    Faraaz Noor Khan Yusufi;Meiyappan Lakshmanan;Ying Swan Ho;Bernard Liat Wen Loo

  • Flux-sum analysis: a metabolite-centric approach for understanding the metabolic network

    Bevan Kai Sheng Chung;Bevan Kai Sheng Chung;Dong-Yup Lee;Dong-Yup Lee

Frequent Co-Authors

Sang Yup Lee
Sang Yup Lee Korea Advanced Institute of Science and Technology
Iftekhar A. Karimi
Iftekhar A. Karimi National University of Singapore
Nathan E. Lewis
Nathan E. Lewis University of California, San Diego
Lars K. Nielsen
Lars K. Nielsen University of Queensland
Bernhard O. Palsson
Bernhard O. Palsson University of California, San Diego
Andre Choo
Andre Choo Agency for Science, Technology and Research
Intawat Nookaew
Intawat Nookaew University of Arkansas for Medical Sciences
Adam M. Feist
Adam M. Feist University of California, San Diego
Jens Nielsen
Jens Nielsen Chalmers University of Technology
Adil Mardinoglu
Adil Mardinoglu Royal Institute of Technology

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