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Biology and Biochemistry

D-Index
69
Citations
39907
World Ranking
7208
National Ranking
25

Overview

Sai Kiang Lim is affiliated with the Agency for Science, Technology and Research in Singapore. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant focus on Molecular Biology, Cancer Research, Genetics, Surgery, and Immunology.

The scientist's work primarily concentrates on topics including extracellular vesicles in disease, microRNA in disease regulation, mesenchymal stem cell research, circular RNAs in diseases, osteoarthritis treatment and mechanisms, bone and joint diseases, and tissue engineering and regenerative medicine.

Among the recent publications attributed to Sai Kiang Lim are:

  • Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches, 2024, Journal of Extracellular Vesicles
  • Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles, 2021, Cytotherapy
  • Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging, 2021, Aging Cell
  • Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles, 2022, Cardiovascular Research
  • International Society for Extracellular Vesicles and International Society for Cell and Gene Therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19, 2020, Cytotherapy

The scientist has collaborated frequently with several coauthors including Bernd Giebel, Ruenn Chai Lai, Rebecca Lim, Bruce L. Levine, and Rachele Ciccocioppo.

Sai Kiang Lim has published extensively in various scientific venues, with a notable number of papers appearing in Cytotherapy, followed by contributions to the International Journal of Molecular Sciences, Aging Cell, Research Square, and Zenodo hosted by CERN.

The research contributions largely encompass extracellular vesicles, mesenchymal stem cell biology, and their applications in regenerative medicine and disease treatments, reflecting an integration of molecular biology approaches with clinical and therapeutic investigations.

Best Publications

  • Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Clotilde Théry;Kenneth W. Witwer;Elena Aikawa;Maria Jose Alcaraz

  • Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.

    Ruenn Chai Lai;Fatih Arslan;May May Lee;Newman Siu Kwan Sze

  • Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

    Thomas Lener;Mario Gimona;Ludwig Aigner;Verena Börger

  • Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

    Hina Kalra;Richard J. Simpson;Hong Ji;Elena Aikawa

  • Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

    Fatih Arslan;Ruenn Chai Lai;Ruenn Chai Lai;Mirjam B. Smeets;Lars Akeroyd

  • Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery☆

    Ronne Wee Yeh Yeo;Ruenn Chai Lai;Bin Zhang;Soon Sim Tan

  • MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

    Shipin Zhang;Shang Jiunn Chuah;Ruenn Chai Lai;James Hoi Po Hui

  • Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium.

    Leo Timmers;Sai Kiang Lim;Fatih Arslan;Jeffrey S. Armstrong

  • Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

    Tian Sheng Chen;Ruenn Chai Lai;May May Lee;Andre Boon Hwa Choo

  • Mesenchymal stem cells secrete immunologically active exosomes.

    Bin Zhang;Yijun Yin;Ruenn Chai Lai;Soon Sim Tan

  • Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

    Ruenn Chai Lai;Tian Sheng Chen;Sai Kiang Lim

  • Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

    S. Zhang;W.C. Chu;R.C. Lai;S.K. Lim;S.K. Lim

  • Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes

    Jung Eun Park;Hon Sen Tan;Arnab Datta;Ruenn Chai Lai

  • Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

    Cheau Yih Tan;Ruenn Chai Lai;Winnie Wong;Yock Young Dan

  • Mesenchymal stem cell exosomes.

    Ruenn Chai Lai;Ronne Wee Yeh Yeo;Sai Kiang Lim;Sai Kiang Lim

  • Exosomes for drug delivery - a novel application for the mesenchymal stem cell.

    Ruenn Chai Lai;Ronne Wee Yeh Yeo;Ronne Wee Yeh Yeo;Kok Hian Tan;Sai Kiang Lim

  • Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

    Chyuan-Sheng Lin;Sai-Kiang Lim;V. D'agati;F. Costantini

  • Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome

    Ruenn Chai Lai;Soon Sim Tan;Bao Ju Teh;Siu Kwan Sze

  • Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

    Leo Timmers;Sai Kiang Lim;Imo E. Hoefer;Fatih Arslan

  • Applying extracellular vesicles based therapeutics in clinical trials

    Thomas Lener;Mario Gimona;Ludwig Aigner;Verena Börger

Frequent Co-Authors

Andre Choo
Andre Choo Agency for Science, Technology and Research
Siu Kwan Sze
Siu Kwan Sze Nanyang Technological University
Gerard Pasterkamp
Gerard Pasterkamp Utrecht University
Bernd Giebel
Bernd Giebel University of Duisburg-Essen
James H.P. Hui
James H.P. Hui University Health System
Mario Gimona
Mario Gimona Paracelsus Medical University
Andrew F. Hill
Andrew F. Hill Victoria University
Kenneth W. Witwer
Kenneth W. Witwer Johns Hopkins University
James P. Tam
James P. Tam Nanyang Technological University

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