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Biology and Biochemistry

D-Index
65
Citations
17911
World Ranking
9040
National Ranking
276

Overview

Zhiyong Lou is affiliated with Tsinghua University in China and has contributed extensively to research in Medicine as well as Biochemistry, Genetics and Molecular Biology. The scientist's work spans several subfields including Infectious Diseases, Molecular Biology, Cardiology and Cardiovascular Medicine, Genetics, and Animal Science and Zoology.

Zhiyong Lou's research primarily focuses on topics related to SARS-CoV-2 and COVID-19, with work covering Viral Infections and Immunology, Viral gastroenteritis research and epidemiology, COVID-19 Clinical Research Studies, Virus-based gene therapy, Animal Virus Infections, and interferon and immune responses.

Some of the recent papers published by Zhiyong Lou include:

  • Structure of the RNA-dependent RNA polymerase from COVID-19 virus, 2020, Science
  • Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial, 2020, The Lancet Infectious Diseases
  • Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase, 2020, Cell
  • Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2, 2020, Cell
  • Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis, 2020, Cell

Frequent coauthors who have collaborated with Zhiyong Lou include:

  • Zihe Rao
  • Liming Yan
  • Yucen Huang
  • Ji Ge
  • Luke W. Guddat

Zhiyong Lou's publications are often found in specific scholarly venues such as:

  • Cell
  • Nature Communications
  • Protein & Cell
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Microbiology

Best Publications

  • Structure of the RNA-dependent RNA polymerase from COVID-19 virus.

    Yan Gao;Yan Gao;Liming Yan;Yucen Huang;Fengjiang Liu

  • The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

    Haitao Yang;Maojun Yang;Yi Ding;Yiwei Liu

  • Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial.

    Shengli Xia;Yuntao Zhang;Yanxia Wang;Hui Wang

  • Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2.

    Hui Wang;Yuntao Zhang;Baoying Huang;Wei Deng

  • Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.

    Quan Wang;Jiqin Wu;Haofeng Wang;Haofeng Wang;Yan Gao

  • Crystal structure of an avian influenza polymerase PA N reveals an endonuclease active site

    Puwei Yuan;Mark Bartlam;Zhiyong Lou;Shoudeng Chen

  • DWARF14 is a non-canonical hormone receptor for strigolactone

    Ruifeng Yao;Zhenhua Ming;Liming Yan;Suhua Li

  • Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex

    Yuanyuan Ma;Lijie Wu;Neil Shaw;Yan Gao

  • A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

    Xiangxi Wang;Wei Peng;Jingshan Ren;Zhongyu Hu

  • Structural Basis for the Recognition of Blood Group Trisaccharides by Norovirus

    Sheng Cao;Zhiyong Lou;Ming Tan;Yutao Chen

  • Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis.

    Zhihui Jia;Liming Yan;Zhilin Ren;Lijie Wu

  • Crystal structure of the polymerase PA C –PB1 N complex from an avian influenza H5N1 virus

    Xiaojing He;Jie Zhou;Mark Bartlam;Rongguang Zhang

  • Structural insight into substrate preference for TET-mediated oxidation

    Lulu Hu;Lulu Hu;Junyan Lu;Jingdong Cheng;Qinhui Rao

  • Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core.

    Yanhui Xu;Zhiyong Lou;Yiwei Liu;Hai Pang

  • Current progress in antiviral strategies.

    Zhiyong Lou;Yuna Sun;Zihe Rao;Zihe Rao

  • Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.

    Liming Yan;Ji Ge;Litao Zheng;Ying Zhang

  • 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.

    Beili Wu;Pengyun Li;Yiwei Liu;Zhiyong Lou

  • A structural view of the antibiotic degradation enzyme NDM-1 from a superbug

    Yu Guo;Jing Wang;Guojun Niu;Wenqing Shui

  • The newly emerged SARS-Like coronavirus HCoV-EMC also has an 'Achilles' heel': current effective inhibitor targeting a 3C-like protease

    Zhilin Ren;Liming Yan;Ning Zhang;Yu Guo

  • Architecture of a SARS-CoV-2 mini replication and transcription complex.

    Liming Yan;Ying Zhang;Ji Ge;Litao Zheng

Frequent Co-Authors

Zihe Rao
Zihe Rao Tsinghua University
Mark Bartlam
Mark Bartlam Nankai University
George F. Gao
George F. Gao Chinese Center For Disease Control and Prevention
Yanhui Xu
Yanhui Xu Shanghai Medical College of Fudan University
Ke-Qin Zhang
Ke-Qin Zhang Yunnan University
David J. Rowlands
David J. Rowlands University of Leeds
Rongguang Zhang
Rongguang Zhang Chinese Academy of Sciences
Po Tien
Po Tien Chinese Academy of Sciences
Jianwei Wang
Jianwei Wang Peking Union Medical College Hospital
John I. Bell
John I. Bell Ellison Institute of Technology

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