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Biology and Biochemistry

D-Index
72
Citations
17925
World Ranking
6326
National Ranking
2962

Research.com Recognitions

  • 2020 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2019 - Fellow, National Academy of Inventors

Overview

Dongsheng Duan is a researcher affiliated with the University of Missouri in the United States. Their primary fields of study include biochemistry, genetics, and molecular biology, with a significant focus on medicine.

Their research spans several subfields, including molecular biology, genetics, cardiology and cardiovascular medicine, physiology, and cell biology. The scientist's key topics of work reflect a strong emphasis on muscle physiology and disorders, virus-based gene therapy research, CRISPR and genetic engineering, adipose tissue and metabolism, viral infections and immunology research, muscle metabolism and nutrition, and cardiomyopathy and myosin studies.

Dongsheng Duan has published extensively in notable venues such as Human Gene Therapy, Molecular Therapy - Methods & Clinical Development, Methods in Molecular Biology, Molecular Therapy, and UNC Libraries.

Some of their recent papers include:

  • Duchenne muscular dystrophy, 2021, Nature Reviews Disease Primers
  • Lethal immunotoxicity in high-dose systemic AAV therapy, 2023, Molecular Therapy

In collaboration with colleagues, they have contributed to studies such as:

  • Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models, 2021, Nature Communications (authored by Chady H. Hakim)
  • Abnormal Calcium Handling in Duchenne Muscular Dystrophy: Mechanisms and Potential Therapies, 2021, Frontiers in Physiology (authored by Satvik Mareedu)
  • Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice, 2020, eLife (authored by Ying Ann Chiao)

Frequent co-authors working closely with Dongsheng Duan include Yongping Yue, Xiufang Pan, Chady H. Hakim, Roland W. Herzog, and James Teixeira.

Dongsheng Duan has received recognition as a Fellow of the American Association for the Advancement of Science (AAAS) in 2020 and as a Fellow of the National Academy of Inventors in 2019.

Best Publications

  • In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

    Christopher E. Nelson;Chady H. Hakim;David G. Ousterout;Pratiksha I. Thakore

  • Duchenne muscular dystrophy.

    Dongsheng Duan;Nathalie Goemans;Shin'ichi Takeda;Eugenio Mercuri

  • Modular flexibility of dystrophin: Implications for gene therapy of Duchenne muscular dystrophy

    Scott Q. Harper;Michael A. Hauser;Michael A. Hauser;Christiana DelloRusso;Christiana DelloRusso;Dongsheng Duan

  • Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

    Dongsheng Duan;Prerna Sharma;Jusan Yang;Yongping Yue

  • Animal models of Duchenne muscular dystrophy: From basic mechanisms to gene therapy

    Joe W. McGreevy;Chady H. Hakim;Mark A. McIntosh;Dongsheng Duan

  • Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.

    Dongsheng Duan;Yongping Yue;Ziying Yan;Jusan Yang

  • Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

    Yi Lai;Gail D. Thomas;Yongping Yue;Hsiao T. Yang

  • Systemic AAV Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy.

    Dongsheng Duan

  • Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy

    Ziying Yan;Yulong Zhang;Dongsheng Duan;John F. Engelhardt

  • Dynamin Is Required for Recombinant Adeno-Associated Virus Type 2 Infection

    Dongsheng Duan;Qiang Li;Aimee W. Kao;Yongping Yue

  • Expanding AAV packaging capacity with trans-splicing or overlapping vectors: a quantitative comparison.

    Dongsheng Duan;Yongping Yue;John F. Engelhardt

  • Contemporary cardiac issues in Duchenne muscular dystrophy.

    Elizabeth M. McNally;Jonathan R. Kaltman;D. Woodrow Benson;Charles E. Canter

  • Real-time, noninvasive in vivo assessment of adeno-associated virus-mediated retinal transduction.

    J Bennett;D Duan;J F Engelhardt;A M Maguire

  • A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation.

    Dongsheng Duan;Yongping Yue;Ziying Yan;John F. Engelhardt

  • Efficient in vivo gene expression by trans -splicing adeno-associated viral vectors

    Yi Lai;Yongping Yue;Mingju Liu;Arkasubhra Ghosh

  • Polarity Influences the Efficiency of Recombinant Adenoassociated Virus Infection in Differentiated Airway Epithelia

    Dongsheng Duan;Yongping Yue;Ziying Yan;Paul B. McCray

  • Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury.

    Mingju Liu;Yongping Yue;Scott Q. Harper;Robert W. Grange

  • Systemic AAV-9 transduction in mice is influenced by animal age but not by the route of administration.

    B Bostick;A Ghosh;Y Yue;C Long

  • Evidence for the Failure of Adeno-associated Virus Serotype 5 to Package a Viral Genome ≥8.2 kb

    Yi Lai;Yongping Yue;Dongsheng Duan

  • In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

    C. E. Nelson;C. H. Hakim;D. G. Ousterout;P. I. Thakore

Frequent Co-Authors

Yongping Yue
Yongping Yue University of Missouri
John F. Engelhardt
John F. Engelhardt University of Iowa
Jeffrey S. Chamberlain
Jeffrey S. Chamberlain University of Washington
Ziying Yan
Ziying Yan University of Iowa
Charles A. Gersbach
Charles A. Gersbach Duke University
Peter S. Rabinovitch
Peter S. Rabinovitch University of Washington
Henk Granzier
Henk Granzier University of Arizona
Wei-Jun Qian
Wei-Jun Qian Pacific Northwest National Laboratory
Annemieke Aartsma-Rus
Annemieke Aartsma-Rus Leiden University Medical Center

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