D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 78 Citations 18,015 176 World Ranking 1947 National Ranking 1098

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Genetics

Titin, Actinin, alpha 2, Obscurin, Sarcomere and Biophysics are his primary areas of study. The various areas that Henk Granzier examines in his Titin study include Cardiac muscle, Anatomy and Myofibril. His Actinin, alpha 2 research focuses on Immunoelectron microscopy and how it connects with Elasticity.

His Obscurin research is multidisciplinary, incorporating elements of Immunoglobulin domain and Gene isoform. He has included themes like Myosin, Myofilament and Muscle contraction in his Sarcomere study. His biological study spans a wide range of topics, including Molecular spring, Crystallography and Actin.

His most cited work include:

  • Folding-Unfolding Transitions in Single Titin Molecules Characterized with Laser Tweezers (978 citations)
  • The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System (506 citations)
  • Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments. (490 citations)

What are the main themes of his work throughout his whole career to date?

Henk Granzier mainly investigates Titin, Sarcomere, Biophysics, Internal medicine and Cell biology. His Titin study combines topics in areas such as Diastole and Anatomy. His Sarcomere research includes themes of Cardiac muscle, Skeletal muscle and Myosin, Actin, Myofilament.

His work focuses on many connections between Biophysics and other disciplines, such as Biochemistry, that overlap with his field of interest in Calcium. His Internal medicine study integrates concerns from other disciplines, such as Endocrinology and Cardiology. The concepts of his Cell biology study are interwoven with issues in Phenotype, Genetics, Myofibril and Gene isoform.

He most often published in these fields:

  • Titin (68.24%)
  • Sarcomere (44.03%)
  • Biophysics (30.82%)

What were the highlights of his more recent work (between 2018-2021)?

  • Internal medicine (28.62%)
  • Cell biology (27.04%)
  • Nebulin (15.09%)

In recent papers he was focusing on the following fields of study:

Internal medicine, Cell biology, Nebulin, Titin and Skeletal muscle are his primary areas of study. His Internal medicine research incorporates themes from Endocrinology and Cardiology. His studies deal with areas such as Phenotype, Myopathy, Myofibril, Muscle contraction and Gene isoform as well as Cell biology.

His Nebulin research incorporates elements of Isometric exercise, Mutation, Nemaline myopathy, Actin and Myosin. His research in Actin intersects with topics in Biophysics, Sarcomere, Protein filament, Disease and Zebrafish. He does research in Titin, focusing on Molecular spring specifically.

Between 2018 and 2021, his most popular works were:

  • Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary. (38 citations)
  • Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance (18 citations)
  • Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice (17 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Folding-Unfolding Transitions in Single Titin Molecules Characterized with Laser Tweezers

Miklós S. Z. Kellermayer;Steven B. Smith;Henk L. Granzier;Carlos Bustamante.
Science (1997)

1354 Citations

The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System

Marie Louise Bang;Thomas Centner;Friderike Fornoff;Adam J. Geach.
Circulation Research (2001)

675 Citations

Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.

H.L. Granzier;T.C. Irving.
Biophysical Journal (1995)

631 Citations

The Giant Protein Titin: A Major Player in Myocardial Mechanics, Signaling, and Disease

Henk L. Granzier;Siegfried Labeit.
Circulation Research (2004)

614 Citations

Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.

Brenda Gerull;Michael Gramlich;John Atherton;Mark McNabb.
Nature Genetics (2002)

577 Citations

Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy

Sherif F. Nagueh;Gopi Shah;Yiming Wu;Guillermo Torre-Amione.
Circulation (2004)

456 Citations

Differential Expression of Cardiac Titin Isoforms and Modulation of Cellular Stiffness

Olivier Cazorla;A Freiburg;M. Helmes;T Centner.
Circulation Research (2000)

444 Citations

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

Thomas Centner;Junko Yano;Eiichi Kimura;Abigail S. McElhinny.
Journal of Molecular Biology (2001)

428 Citations

Muscle assembly: a titanic achievement?

Carol C Gregorio;Henk Granzier;Hiroyuki Sorimachi;Siegfried Labeit.
Current Opinion in Cell Biology (1999)

420 Citations

Myocardial stiffness in patients with heart failure and a preserved ejection fraction contributions of collagen and titin

Michael R. Zile;Catalin F. Baicu;John S. Ikonomidis;Robert E. Stroud.
Circulation (2015)

410 Citations

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Best Scientists Citing Henk Granzier

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Harry Perkins Institute of Medical Research

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