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D-Index & Metrics

Biology and Biochemistry

D-Index
101
Citations
31628
World Ranking
1472
National Ranking
839

Overview

Henk Granzier is affiliated with the University of Arizona in the United States. Their research contributions fall primarily within the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with significant publication records in Cardiology and Cardiovascular Medicine, Molecular Biology, Genetics, Cell Biology, and Biomedical Engineering.

The scientist's work covers various main topics including Cardiomyopathy and Myosin Studies, Muscle Physiology and Disorders, Cardiovascular Effects of Exercise, Cardiovascular Function and Risk Factors, Neurogenetic and Muscular Disorders Research, RNA Research and Splicing, and Cellular Mechanics and Interactions.

Recent scholarly articles authored or co-authored by Henk Granzier include:

  • Research Priorities for Heart Failure With Preserved Ejection Fraction, 2020, Circulation
  • Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice, 2020, eLife
  • MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling, 2020, Cardiovascular Research
  • HDAC6 modulates myofibril stiffness and diastolic function of the heart, 2022, Journal of Clinical Investigation
  • Phosphodiesterase 9a Inhibition in Mouse Models of Diastolic Dysfunction, 2020, Circulation Heart Failure

Henk Granzier frequently publishes in venues such as Circulation Research, The Journal of General Physiology, Frontiers in Physiology, International Journal of Molecular Sciences, and Neuromuscular Disorders, each with five or more contributions.

They have collaborated extensively with several researchers, including:

  • Zaynab Hourani
  • Coen A. C. Ottenheijm
  • Mei Methawasin
  • John E. Smith
  • Robbert van der Pijl

Best Publications

  • Folding-Unfolding Transitions in Single Titin Molecules Characterized with Laser Tweezers

    Miklós S. Z. Kellermayer;Steven B. Smith;Henk L. Granzier;Carlos Bustamante

  • The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System

    Marie Louise Bang;Thomas Centner;Friderike Fornoff;Adam J. Geach

  • Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.

    H.L. Granzier;T.C. Irving

  • Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.

    Brenda Gerull;Michael Gramlich;John Atherton;Mark McNabb

  • The Giant Protein Titin: A Major Player in Myocardial Mechanics, Signaling, and Disease

    Henk L. Granzier;Siegfried Labeit

  • Myocardial stiffness in patients with heart failure and a preserved ejection fraction contributions of collagen and titin

    Michael R. Zile;Catalin F. Baicu;John S. Ikonomidis;Robert E. Stroud

  • Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy

    Sherif F. Nagueh;Gopi Shah;Yiming Wu;Guillermo Torre-Amione

  • Differential Expression of Cardiac Titin Isoforms and Modulation of Cellular Stiffness

    Olivier Cazorla;A Freiburg;M. Helmes;T Centner

  • Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

    Thomas Centner;Junko Yano;Eiichi Kimura;Abigail S. McElhinny

  • Series of Exon-Skipping Events in the Elastic Spring Region of Titin as the Structural Basis for Myofibrillar Elastic Diversity

    Alexandra Freiburg;Karoly Trombitas;Wolfgang Hell;Olivier Cazorla

  • Muscle assembly: a titanic achievement?

    Carol C Gregorio;Henk Granzier;Hiroyuki Sorimachi;Siegfried Labeit

  • Calcium-dependent molecular spring elements in the giant protein titin

    Dietmar Labeit;Kaori Watanabe;Christian Witt;Hideaki Fujita

  • The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.

    Melanie K. Miller;Marie Louise Bang;Christian C. Witt;Dietmar Labeit

  • Developmental Control of Titin Isoform Expression and Passive Stiffness in Fetal and Neonatal Myocardium

    Sunshine Lahmers;Yiming Wu;Douglas R. Call;Siegfried Labeit

  • The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity.

    Carol C. Gregorio;Karoly Trombitás;Thomas Centner;Bernhard Kolmerer

  • Right ventricular diastolic impairment in patients with pulmonary arterial hypertension

    Silvia Rain;M Louis Handoko;Pia Trip;C Tji-Joong Gan

  • Protein Kinase A Phosphorylates Titin’s Cardiac-Specific N2B Domain and Reduces Passive Tension in Rat Cardiac Myocytes

    R. Yamasaki;Y. Wu;M. McNabb;M. Greaser

  • Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies

    Marie Louise Bang;Ryan E. Mudry;Abigail S. McElhinny;Karoly Trombitás

  • MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.

    Stephanie H. Witt;Henk Granzier;Christian C. Witt;Siegfried Labeit

  • Cardiac Titin A Multifunctional Giant

    Martin M. LeWinter;Henk Granzier

Frequent Co-Authors

Michael Gotthardt
Michael Gotthardt University of Bonn
Siegfried Labeit
Siegfried Labeit European Bioinformatics Institute
Alan H. Beggs
Alan H. Beggs Harvard Medical School
Carol C. Gregorio
Carol C. Gregorio University of Arizona
Hiroyuki Sorimachi
Hiroyuki Sorimachi Tokyo Metropolitan Institute of Medical Science
Wolfgang A. Linke
Wolfgang A. Linke University of Münster
Marion L. Greaser
Marion L. Greaser University of Wisconsin–Madison
Carlos Bustamante
Carlos Bustamante Stanford University
Monkol Lek
Monkol Lek Yale University
Daniel G. MacArthur
Daniel G. MacArthur Garvan Institute of Medical Research

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