Siegfried Labeit

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Best Publications

• Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity

  Siegfried Labeit;Bernhard Kolmerer

  1697
  Citations

• Cloning of the T gene required in mesoderm formation in the mouse

  Bernhard G. Herrmann;Siegfried Labeit;Annemarie Poustka;Thomas R. King

  1226
  Citations

• The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System

  Marie Louise Bang;Thomas Centner;Friderike Fornoff;Adam J. Geach

  821
  Citations

• Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.

  Brenda Gerull;Michael Gramlich;John Atherton;Mark McNabb

  707
  Citations

• The Giant Protein Titin: A Major Player in Myocardial Mechanics, Signaling, and Disease

  Henk L. Granzier;Siegfried Labeit

  652
  Citations

• Tibial Muscular Dystrophy Is a Titinopathy Caused by Mutations in TTN, the Gene Encoding the Giant Skeletal-Muscle Protein Titin

  Peter Hackman;Anna Vihola;Henna Haravuori;Sylvie Marchand

  596
  Citations

• Cardiac myosin binding protein-C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathy.

  Bonne G;Bercovici J;Cruaud C

  592
  Citations

• Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy

  Sherif F. Nagueh;Gopi Shah;Yiming Wu;Guillermo Torre-Amione

  552
  Citations

• Differential Expression of Cardiac Titin Isoforms and Modulation of Cellular Stiffness

  Olivier Cazorla;A Freiburg;M. Helmes;T Centner

  515
  Citations

• Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

  Thomas Centner;Junko Yano;Eiichi Kimura;Abigail S. McElhinny

  482
  Citations

• Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction?

  M. Gautel;O. Zuffardi;A. Freiburg;S. Labeit

  476
  Citations

• Towards a molecular understanding of titin.

  S. Labeit;M. Gautel;A. Lakey;J. Trinick

  455
  Citations

• Series of Exon-Skipping Events in the Elastic Spring Region of Titin as the Structural Basis for Myofibrillar Elastic Diversity

  Alexandra Freiburg;Karoly Trombitas;Wolfgang Hell;Olivier Cazorla

  451
  Citations

• Muscle assembly: a titanic achievement?

  Carol C Gregorio;Henk Granzier;Hiroyuki Sorimachi;Siegfried Labeit

  437
  Citations

• Calcium-dependent molecular spring elements in the giant protein titin

  Dietmar Labeit;Kaori Watanabe;Christian Witt;Hideaki Fujita

  420
  Citations

• Organization and Sequence of Human Cardiac Myosin Binding Protein C Gene (MYBPC3) and Identification of Mutations Predicted to Produce Truncated Proteins in Familial Hypertrophic Cardiomyopathy

  G Bonne;E Bährend;B Yu

  404
  Citations

• The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.

  Melanie K. Miller;Marie Louise Bang;Christian C. Witt;Dietmar Labeit

  401
  Citations

• Developmental Control of Titin Isoform Expression and Passive Stiffness in Fetal and Neonatal Myocardium

  Sunshine Lahmers;Yiming Wu;Douglas R. Call;Siegfried Labeit

  398
  Citations

• The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity.

  Carol C. Gregorio;Karoly Trombitás;Thomas Centner;Bernhard Kolmerer

  389
  Citations

• Protein Kinase A Phosphorylates Titin’s Cardiac-Specific N2B Domain and Reduces Passive Tension in Rat Cardiac Myocytes

  R. Yamasaki;Y. Wu;M. McNabb;M. Greaser

  370
  Citations