His main research concerns Titin, Obscurin, Sarcomere, Myofibril and Actinin, alpha 2. Titin is closely attributed to Biophysics in his study. His studies in Sarcomere integrate themes in fields like Cardiomyopathy, Cardiac muscle, Isometric exercise and Actin.
His Myofibril study combines topics from a wide range of disciplines, such as Muscle contraction and Myosin. His Actinin, alpha 2 study combines topics in areas such as Molecular spring, Molecular biology and Myotilin. His study on Heart failure, Diastole and Heart metabolism is often connected to Spermidine as part of broader study in Internal medicine.
His primary scientific interests are in Titin, Internal medicine, Biophysics, Sarcomere and Cell biology. His Titin research is multidisciplinary, incorporating elements of Myofibril and Phosphorylation. His Internal medicine research is multidisciplinary, incorporating perspectives in Endocrinology and Cardiology.
In his work, Isometric exercise is strongly intertwined with Anatomy, which is a subfield of Biophysics. He focuses mostly in the field of Sarcomere, narrowing it down to topics relating to Myofilament and, in certain cases, Troponin I. His work in Cell biology addresses subjects such as Cardiomyopathy, which are connected to disciplines such as Mutation.
Wolfgang A. Linke mostly deals with Titin, Cell biology, Biophysics, Sarcomere and Myocyte. His work carried out in the field of Titin brings together such families of science as Immunoglobulin domain, Dietary intake and Actin. His Cell biology research integrates issues from Cardiac function curve, Cardiomyopathy and Myopathy.
Wolfgang A. Linke works mostly in the field of Biophysics, limiting it down to topics relating to Muscle contraction and, in certain cases, Tethering. His Sarcomere research incorporates elements of Downregulation and upregulation, Function, Phosphorylation and Myofilament. The study incorporates disciplines such as Muscle protein, Transduction and Myosin in addition to Myocyte.
The scientist’s investigation covers issues in Cell biology, Sarcomere, Titin, Internal medicine and Cardiology. In general Cell biology study, his work on Myosin often relates to the realm of Golgi apparatus and Force generation, thereby connecting several areas of interest. Wolfgang A. Linke interconnects Knockout mouse, Motility, Phosphorylation, Western blot and Gene isoform in the investigation of issues within Sarcomere.
His Titin research entails a greater understanding of Myocyte. His biological study spans a wide range of topics, including Mechanotransduction, Biophysics and Protein folding. His work on Heart failure, Therapeutic approach, Ventricle and Disease as part of general Internal medicine study is frequently linked to Doxorubicin, therefore connecting diverse disciplines of science.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Myocardial structure and function differ in systolic and diastolic heart failure.
Loek van Heerebeek;Attila Borbély;Hans W M Niessen;Jean G F Bronzwaer.
Circulation (2006)
Reverse engineering of the giant muscle protein titin
Hongbin Li;Wolfgang A. Linke;Andres F. Oberhauser;Mariano Carrion-Vazquez.
Nature (2002)
Cardioprotection and lifespan extension by the natural polyamine spermidine
Tobias Eisenberg;Mahmoud Abdellatif;Sabrina Schroeder;Uwe Primessnig;Uwe Primessnig.
Nature Medicine (2016)
Titin Isoform Switch in Ischemic Human Heart Disease
Ciprian Neagoe;Michael Kulke;Federica del Monte;Judith K. Gwathmey.
Circulation (2002)
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
John Travis Hinson;Anant Chopra;N. Nafissi;William Polacheck.
Science (2015)
Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs
Martina Krüger;Sebastian Kötter;Anika Grützner;Patrick Lang.
Circulation Research (2008)
Passive Stiffness Changes Caused by Upregulation of Compliant Titin Isoforms in Human Dilated Cardiomyopathy Hearts
I. Makarenko;C.A. Opitz;M.C. Leake;C. Neagoe.
Circulation Research (2004)
Sense and stretchability: The role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction†
Wolfgang A. Linke.
Cardiovascular Research (2007)
TOWARDS A MOLECULAR UNDERSTANDING OF THE ELASTICITY OF TITIN
W A Linke;M Ivemeyer;N Olivieri;B Kolmerer.
Journal of Molecular Biology (1996)
Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.
Malte Tiburcy;James E. Hudson;Paul Balfanz;Susanne Schlick.
Circulation (2017)
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