D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 58 Citations 11,090 112 World Ranking 5996 National Ranking 454

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Biochemistry

His main research concerns Titin, Obscurin, Sarcomere, Myofibril and Actinin, alpha 2. Titin is closely attributed to Biophysics in his study. His studies in Sarcomere integrate themes in fields like Cardiomyopathy, Cardiac muscle, Isometric exercise and Actin.

His Myofibril study combines topics from a wide range of disciplines, such as Muscle contraction and Myosin. His Actinin, alpha 2 study combines topics in areas such as Molecular spring, Molecular biology and Myotilin. His study on Heart failure, Diastole and Heart metabolism is often connected to Spermidine as part of broader study in Internal medicine.

His most cited work include:

  • Myocardial structure and function differ in systolic and diastolic heart failure. (508 citations)
  • Reverse engineering of the giant muscle protein titin (415 citations)
  • Cardioprotection and lifespan extension by the natural polyamine spermidine (403 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Titin, Internal medicine, Biophysics, Sarcomere and Cell biology. His Titin research is multidisciplinary, incorporating elements of Myofibril and Phosphorylation. His Internal medicine research is multidisciplinary, incorporating perspectives in Endocrinology and Cardiology.

In his work, Isometric exercise is strongly intertwined with Anatomy, which is a subfield of Biophysics. He focuses mostly in the field of Sarcomere, narrowing it down to topics relating to Myofilament and, in certain cases, Troponin I. His work in Cell biology addresses subjects such as Cardiomyopathy, which are connected to disciplines such as Mutation.

He most often published in these fields:

  • Titin (65.27%)
  • Internal medicine (34.73%)
  • Biophysics (30.96%)

What were the highlights of his more recent work (between 2018-2021)?

  • Titin (65.27%)
  • Cell biology (28.03%)
  • Biophysics (30.96%)

In recent papers he was focusing on the following fields of study:

Wolfgang A. Linke mostly deals with Titin, Cell biology, Biophysics, Sarcomere and Myocyte. His work carried out in the field of Titin brings together such families of science as Immunoglobulin domain, Dietary intake and Actin. His Cell biology research integrates issues from Cardiac function curve, Cardiomyopathy and Myopathy.

Wolfgang A. Linke works mostly in the field of Biophysics, limiting it down to topics relating to Muscle contraction and, in certain cases, Tethering. His Sarcomere research incorporates elements of Downregulation and upregulation, Function, Phosphorylation and Myofilament. The study incorporates disciplines such as Muscle protein, Transduction and Myosin in addition to Myocyte.

Between 2018 and 2021, his most popular works were:

  • The Translational Landscape of the Human Heart (151 citations)
  • The continuous heart failure spectrum: moving beyond an ejection fraction classification (75 citations)
  • Treatments targeting inotropy (40 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Biochemistry

The scientist’s investigation covers issues in Cell biology, Sarcomere, Titin, Internal medicine and Cardiology. In general Cell biology study, his work on Myosin often relates to the realm of Golgi apparatus and Force generation, thereby connecting several areas of interest. Wolfgang A. Linke interconnects Knockout mouse, Motility, Phosphorylation, Western blot and Gene isoform in the investigation of issues within Sarcomere.

His Titin research entails a greater understanding of Myocyte. His biological study spans a wide range of topics, including Mechanotransduction, Biophysics and Protein folding. His work on Heart failure, Therapeutic approach, Ventricle and Disease as part of general Internal medicine study is frequently linked to Doxorubicin, therefore connecting diverse disciplines of science.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Myocardial structure and function differ in systolic and diastolic heart failure.

Loek van Heerebeek;Attila Borbély;Hans W M Niessen;Jean G F Bronzwaer.
Circulation (2006)

703 Citations

Reverse engineering of the giant muscle protein titin

Hongbin Li;Wolfgang A. Linke;Andres F. Oberhauser;Mariano Carrion-Vazquez.
Nature (2002)

554 Citations

Cardioprotection and lifespan extension by the natural polyamine spermidine

Tobias Eisenberg;Mahmoud Abdellatif;Sabrina Schroeder;Uwe Primessnig;Uwe Primessnig.
Nature Medicine (2016)

474 Citations

Titin Isoform Switch in Ischemic Human Heart Disease

Ciprian Neagoe;Michael Kulke;Federica del Monte;Judith K. Gwathmey.
Circulation (2002)

419 Citations

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

John Travis Hinson;Anant Chopra;N. Nafissi;William Polacheck.
Science (2015)

384 Citations

Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs

Martina Krüger;Sebastian Kötter;Anika Grützner;Patrick Lang.
Circulation Research (2008)

384 Citations

Passive Stiffness Changes Caused by Upregulation of Compliant Titin Isoforms in Human Dilated Cardiomyopathy Hearts

I. Makarenko;C.A. Opitz;M.C. Leake;C. Neagoe.
Circulation Research (2004)

362 Citations

Sense and stretchability: The role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction†

Wolfgang A. Linke.
Cardiovascular Research (2007)

331 Citations

TOWARDS A MOLECULAR UNDERSTANDING OF THE ELASTICITY OF TITIN

W A Linke;M Ivemeyer;N Olivieri;B Kolmerer.
Journal of Molecular Biology (1996)

315 Citations

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.

Malte Tiburcy;James E. Hudson;Paul Balfanz;Susanne Schlick.
Circulation (2017)

302 Citations

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