World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
8684
World Ranking
18363
National Ranking
7498

Overview

Ziying Yan is affiliated with the University of Iowa in the United States, with a research focus centered on medicine and biochemistry, genetics, and molecular biology. Their work spans several subfields including molecular biology, pulmonary and respiratory medicine, infectious diseases, genetics, and epidemiology.

The scientist's research topics cover a range of subjects related to viral infections and gene therapy. Key areas of interest include:

  • Virus-based gene therapy research
  • Respiratory viral infections research
  • Viral gastroenteritis research and epidemiology
  • Neonatal respiratory health research
  • RNA interference and gene delivery
  • CRISPR and genetic engineering
  • Cystic fibrosis research advances

Ziying Yan has contributed to multiple peer-reviewed journals, frequently publishing in venues such as:

  • mBio
  • Human Gene Therapy
  • Molecular Therapy - Methods & Clinical Development
  • bioRxiv (Cold Spring Harbor Laboratory)
  • JCI Insight

Recent significant papers include:

  • Long-Term Modeling of SARS-CoV-2 Infection of In Vitro Cultured Polarized Human Airway Epithelium, 2020, mBio
  • Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy, 2024, Nature Biotechnology
  • Transgenic ferret models define pulmonary ionocyte diversity and function, 2023, Nature
  • Viral Vectors, Animal Models, and Cellular Targets for Gene Therapy of Cystic Fibrosis Lung Disease, 2020, Human Gene Therapy
  • Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication, 2023, mBio

Their frequent collaborators reflect a network of researchers working in related biomedical and molecular biology fields. Notable coauthors include Jianming Qiu, John F. Engelhardt, Zehua Feng, Siyuan Hao, and Kang Ning.

Best Publications

  • Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer

    Christopher S. Rogers;Yanhong Hao;Tatiana Rokhlina;Melissa Samuel

  • Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.

    Dongsheng Duan;Yongping Yue;Ziying Yan;Jusan Yang

  • Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis

    Xingshen Sun;Hongshu Sui;John T. Fisher;Ziying Yan

  • Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy

    Ziying Yan;Yulong Zhang;Dongsheng Duan;John F. Engelhardt

  • Intracellular trafficking of adeno-associated viral vectors

    W Ding;L Zhang;Z Yan;J F Engelhardt

  • Ubiquitination of both Adeno-Associated Virus Type 2 and 5 Capsid Proteins Affects the Transduction Efficiency of Recombinant Vectors

    Ziying Yan;Roman Zak;G. W. Gant Luxton;Teresa C. Ritchie

  • Virus-Mediated Transduction of Murine Retina with Adeno-Associated Virus: Effects of Viral Capsid and Genome Size

    Grace S. Yang;Michael Schmidt;Ziying Yan;Jonathan D. Lindbloom

  • A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation.

    Dongsheng Duan;Yongping Yue;Ziying Yan;John F. Engelhardt

  • Polarity Influences the Efficiency of Recombinant Adenoassociated Virus Infection in Differentiated Airway Epithelia

    Dongsheng Duan;Yongping Yue;Ziying Yan;Paul B. McCray

  • Adeno-associated virus–targeted disruption of the CFTR gene in cloned ferrets

    Xingshen Sun;Ziying Yan;Yaling Yi;Ziyi Li

  • Establishment of a Reverse Genetics System for Studying Human Bocavirus in Human Airway Epithelia

    Qinfeng Huang;Xuefeng Deng;Xuefeng Deng;Ziying Yan;Fang Cheng

  • Distinct Classes of Proteasome-Modulating Agents Cooperatively Augment Recombinant Adeno-Associated Virus Type 2 and Type 5-Mediated Transduction from the Apical Surfaces of Human Airway Epithelia

    Ziying Yan;Roman Zak;Yulong Zhang;Wei Ding

  • Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV Receptor

    Sirika Pillay;Wei Zou;Fang Cheng;Andreas S. Puschnik

  • Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size

    Matthew B. Johnson;Matthew B. Johnson;Xingshen Sun;Andrew Kodani;Andrew Kodani;Rebeca Borges-Monroy;Rebeca Borges-Monroy

  • Inverted Terminal Repeat Sequences Are Important for Intermolecular Recombination and Circularization of Adeno-Associated Virus Genomes

    Ziying Yan;Roman Zak;Yulong Zhang;John F. Engelhardt

  • Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets

    Alicia K. Olivier;Yaling Yi;Xingshen Sun;Hongshu Sui

  • Structural analysis of adeno-associated virus transduction circular intermediates.

    Dongsheng Duan;Ziying Yan;Yongping Yue;John F. Engelhardt

  • In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis

    Xingshen Sun;Yaling Yi;Ziying Yan;Bradley H. Rosen

  • Lung Phenotype of Juvenile and Adult Cystic Fibrosis Transmembrane Conductance Regulator–Knockout Ferrets

    Xingshen Sun;Alicia K. Olivier;Bo Liang;Yaling Yi

  • Enhancement of Muscle Gene Delivery with Pseudotyped Adeno-Associated Virus Type 5 Correlates with Myoblast Differentiation

    Dongsheng Duan;Ziying Yan;Yongping Yue;Wei Ding

Frequent Co-Authors

John F. Engelhardt
John F. Engelhardt University of Iowa
Jianming Qiu
Jianming Qiu University of Kansas
Dongsheng Duan
Dongsheng Duan University of Missouri
Michael J. Welsh
Michael J. Welsh University of Iowa
Randall S. Prather
Randall S. Prather University of Missouri
David K. Meyerholz
David K. Meyerholz University of Iowa
David A. Stoltz
David A. Stoltz University of Iowa
Paul B. McCray
Paul B. McCray University of Iowa
William B. Guggino
William B. Guggino Johns Hopkins University
Dirk Grimm
Dirk Grimm Heidelberg University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Ziying Yan

Trending Scientists