Michael C. Holmes mostly deals with Genetics, Zinc finger nuclease, Genome editing, Gene and Zinc finger. The various areas that Michael C. Holmes examines in his Genetics study include Computational biology and Cell biology. His Cell biology research includes themes of Molecular biology and Gene delivery.
His Zinc finger nuclease research incorporates themes from Endogeny and DNA, Nuclease. Transcription activator-like effector nuclease and Genome engineering are the primary areas of interest in his Genome editing study. His Zinc finger study combines topics in areas such as Reverse genetics and Virology.
Michael C. Holmes spends much of his time researching Zinc finger nuclease, Gene, Genetics, Genome editing and Cell biology. His Zinc finger nuclease study is concerned with the larger field of Zinc finger. He works mostly in the field of Gene, limiting it down to concerns involving Cleavage and, occasionally, Polynucleotide.
Genetics is closely attributed to Computational biology in his study. His study in Transcription activator-like effector nuclease and Genome engineering is carried out as part of his studies in Genome editing. His study in Cell biology is interdisciplinary in nature, drawing from both Cell culture, Gene delivery and T-cell receptor.
His primary areas of study are Genome editing, Haematopoiesis, Zinc finger nuclease, Cell biology and Genetic enhancement. His Genome editing research includes elements of Plasmid, Molecular biology, Cas9, Hematopoietic stem cell and Computational biology. His Haematopoiesis research incorporates elements of Progenitor cell, CD34, Immunology and Bioinformatics.
His Zinc finger nuclease research is multidisciplinary, incorporating perspectives in Severe combined immunodeficiency and In vivo. His Cell biology study combines topics from a wide range of disciplines, such as Messenger RNA, Gene, Transgene, Electroporation and Endogeny. His work on Locus as part of general Genetics research is frequently linked to Safe harbor, bridging the gap between disciplines.
The scientist’s investigation covers issues in Genome editing, Genetic enhancement, Zinc finger nuclease, Cancer research and Progenitor cell. His studies deal with areas such as Transgene and Cell biology as well as Genome editing. His Zinc finger nuclease study incorporates themes from RNA, Gene expression and Computational biology.
His Cancer research research is multidisciplinary, incorporating elements of CD34, Hematopoietic stem cell transplantation, Stem cell, Immunology and In vivo. His Progenitor cell study integrates concerns from other disciplines, such as Haematopoiesis, Stem-cell therapy, Transplantation, Cell therapy and Globin. His Genome research focuses on subjects like Molecular biology, which are linked to Gene targeting and T cell.
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A TALE nuclease architecture for efficient genome editing
Jeffrey C Miller;Siyuan Tan;Guijuan Qiao;Kyle A Barlow.
Nature Biotechnology (2011)
Genome editing with engineered zinc finger nucleases
Fyodor D. Urnov;Edward J. Rebar;Michael C. Holmes;H. Steve Zhang.
Nature Reviews Genetics (2010)
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
Fyodor D. Urnov;Jeffrey C. Miller;Ya-Li Lee;Christian M. Beausejour.
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.
Pablo Tebas;David Stein;Winson W. Tang;Ian Frank.
The New England Journal of Medicine (2014)
An improved zinc-finger nuclease architecture for highly specific genome editing
Jeffrey C Miller;Michael C Holmes;Jianbin Wang;Dmitry Y Guschin.
Nature Biotechnology (2007)
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
Elena E. Perez;Jianbin Wang;Jeffrey C. Miller;Yann Jouvenot;Yann Jouvenot.
Nature Biotechnology (2008)
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Aaron D. Goldberg;Laura A. Banaszynski;Kyung Min Noh;Peter W. Lewis.
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
A. Lombardo;A. Lombardo;P. Genovese;P. Genovese;C.M. Beausejour;C.M. Beausejour;S. Colleoni;S. Colleoni.
Nature Biotechnology (2007)
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
Nathalia Holt;Jianbin Wang;Kenneth Kim;Geoffrey Friedman.
Nature Biotechnology (2010)
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
Kosuke Yusa;S. Tamir Rashid;Helene Strick-Marchand;Helene Strick-Marchand;Ignacio Varela.
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