What is he best known for?
The fields of study he is best known for:
Michael C. Holmes mostly deals with Genetics, Zinc finger nuclease, Genome editing, Gene and Zinc finger.
The various areas that Michael C. Holmes examines in his Genetics study include Computational biology and Cell biology.
His Cell biology research includes themes of Molecular biology and Gene delivery.
His Zinc finger nuclease research incorporates themes from Endogeny and DNA, Nuclease.
Transcription activator-like effector nuclease and Genome engineering are the primary areas of interest in his Genome editing study.
His Zinc finger study combines topics in areas such as Reverse genetics and Virology.
His most cited work include:
- A TALE nuclease architecture for efficient genome editing (1772 citations)
- Genome editing with engineered zinc finger nucleases (1604 citations)
- Highly efficient endogenous human gene correction using designed zinc-finger nucleases (1526 citations)
What are the main themes of his work throughout his whole career to date?
Michael C. Holmes spends much of his time researching Zinc finger nuclease, Gene, Genetics, Genome editing and Cell biology.
His Zinc finger nuclease study is concerned with the larger field of Zinc finger.
He works mostly in the field of Gene, limiting it down to concerns involving Cleavage and, occasionally, Polynucleotide.
Genetics is closely attributed to Computational biology in his study.
His study in Transcription activator-like effector nuclease and Genome engineering is carried out as part of his studies in Genome editing.
His study in Cell biology is interdisciplinary in nature, drawing from both Cell culture, Gene delivery and T-cell receptor.
He most often published in these fields:
- Zinc finger nuclease (43.41%)
- Gene (33.17%)
- Genetics (29.27%)
What were the highlights of his more recent work (between 2015-2021)?
- Genome editing (30.24%)
- Haematopoiesis (19.51%)
- Zinc finger nuclease (43.41%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Genome editing, Haematopoiesis, Zinc finger nuclease, Cell biology and Genetic enhancement.
His Genome editing research includes elements of Plasmid, Molecular biology, Cas9, Hematopoietic stem cell and Computational biology.
His Haematopoiesis research incorporates elements of Progenitor cell, CD34, Immunology and Bioinformatics.
His Zinc finger nuclease research is multidisciplinary, incorporating perspectives in Severe combined immunodeficiency and In vivo.
His Cell biology study combines topics from a wide range of disciplines, such as Messenger RNA, Gene, Transgene, Electroporation and Endogeny.
His work on Locus as part of general Genetics research is frequently linked to Safe harbor, bridging the gap between disciplines.
Between 2015 and 2021, his most popular works were:
- Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1 (107 citations)
- Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34 + Hematopoietic Stem and Progenitor Cells (89 citations)
- Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery. (89 citations)
In his most recent research, the most cited papers focused on:
The scientist’s investigation covers issues in Genome editing, Genetic enhancement, Zinc finger nuclease, Cancer research and Progenitor cell.
His studies deal with areas such as Transgene and Cell biology as well as Genome editing.
His Zinc finger nuclease study incorporates themes from RNA, Gene expression and Computational biology.
His Cancer research research is multidisciplinary, incorporating elements of CD34, Hematopoietic stem cell transplantation, Stem cell, Immunology and In vivo.
His Progenitor cell study integrates concerns from other disciplines, such as Haematopoiesis, Stem-cell therapy, Transplantation, Cell therapy and Globin.
His Genome research focuses on subjects like Molecular biology, which are linked to Gene targeting and T cell.
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