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Michael C. Holmes

Michael C. Holmes

D-Index & Metrics

Genetics

D-Index
67
Citations
32474
World Ranking
2486
National Ranking
1115

Overview

Michael C. Holmes is affiliated with Ambys Medicines in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with a notable focus on molecular biology and oncology.

Their recent publications demonstrate active engagement in advanced therapeutic and genetic engineering fields. Significant papers include:

  • Off-the-shelf, steroid-resistant, IL13Rα2-specific CAR T cells for treatment of glioblastoma (2022, Neuro-Oncology)
  • Persistent repression of tau in the brain using engineered zinc finger protein transcription factors (2021, Science Advances)
  • AAV2/6 Gene Therapy in a Murine Model of Fabry Disease Results in Supraphysiological Enzyme Activity and Effective Substrate Reduction (2020, Molecular Therapy - Methods & Clinical Development)
  • ZFN-mediated in vivo gene editing in hepatocytes leads to supraphysiologic α-Gal A activity and effective substrate reduction in Fabry mice (2021, Molecular Therapy)
  • Deploying an RNA-Based Gene Writer System and Lipid Nanoparticle (LNP) Delivery to Generate Functional Chimeric Antigen Receptor (CAR) T Cells with in Vitro and In Vivo Anti-Tumor Activity (2023, Blood)

The most frequent publication venues include Blood, Neuro-Oncology, Science Advances, Molecular Therapy - Methods & Clinical Development, and Molecular Therapy. These venues reflect a focus on clinical and translational research, particularly concerning gene therapy and immunotherapy.

Holmes collaborates regularly with several researchers, including Jason Rodriguez, Cecilia Cotta-Ramusino, Alberto De Iaco, James B. Rottman, and Yu Cao, each with multiple joint publications. This suggests active engagement in collaborative research projects within related fields.

The main fields of study encompass medicine and biochemistry, genetics, and molecular biology, with subfields notably covering molecular biology, oncology, physiology, epidemiology, and biomedical engineering. The breadth of subfields indicates a multidisciplinary approach to scientific inquiry.

The principal research topics of Holmes include:

  • CAR-T cell therapy research
  • Lysosomal Storage Disorders Research
  • Trypanosoma species research and implications
  • CRISPR and Genetic Engineering
  • RNA Interference and Gene Delivery
  • Nanowire Synthesis and Applications
  • Advancements in Semiconductor Devices and Circuit Design

Best Publications

  • Genome editing with engineered zinc finger nucleases

    Fyodor D. Urnov;Edward J. Rebar;Michael C. Holmes;H. Steve Zhang

  • A TALE nuclease architecture for efficient genome editing

    Jeffrey C Miller;Siyuan Tan;Guijuan Qiao;Kyle A Barlow

  • Highly efficient endogenous human gene correction using designed zinc-finger nucleases

    Fyodor D. Urnov;Jeffrey C. Miller;Ya-Li Lee;Christian M. Beausejour

  • Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.

    Pablo Tebas;David Stein;Winson W. Tang;Ian Frank

  • An improved zinc-finger nuclease architecture for highly specific genome editing

    Jeffrey C Miller;Michael C Holmes;Jianbin Wang;Dmitry Y Guschin

  • Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

    Aaron D. Goldberg;Laura A. Banaszynski;Kyung Min Noh;Peter W. Lewis

  • Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

    Elena E. Perez;Jianbin Wang;Jeffrey C. Miller;Yann Jouvenot;Yann Jouvenot

  • Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

    A. Lombardo;A. Lombardo;P. Genovese;P. Genovese;C.M. Beausejour;C.M. Beausejour;S. Colleoni;S. Colleoni

  • Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

    Nathalia Holt;Jianbin Wang;Kenneth Kim;Geoffrey Friedman

  • Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

    Kosuke Yusa;S. Tamir Rashid;Helene Strick-Marchand;Helene Strick-Marchand;Ignacio Varela

  • In vivo genome editing restores haemostasis in a mouse model of haemophilia

    Hojun Li;Virginia Haurigot;Yannick Doyon;Tianjian Li

  • Targeted genome editing in human repopulating haematopoietic stem cells

    Pietro Genovese;Giulia Schiroli;Giulia Escobar;Tiziano Di Tomaso

  • An unbiased genome-wide analysis of zinc-finger nuclease specificity

    Richard Gabriel;Angelo Lombardo;Anne Arens;Jeffrey C Miller

  • A rapid and general assay for monitoring endogenous gene modification.

    Dmitry Guschin;Adam James Waite;Adam James Waite;George E. Katibah;Jeffrey C. Miller

  • A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

    Hiroki Torikai;Andreas Reik;Pei Qi Liu;Yuanyue Zhou

  • Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

    Elena Provasi;Pietro Genovese;Angelo Lombardo;Zulma Magnani

  • Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases.

    Erica A. Moehle;Jeremy M. Rock;Ya-Li Lee;Yann Jouvenot

  • Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

    Yannick Doyon;Thuy D Vo;Matthew C Mendel;Shon G Greenberg

  • Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

    Yolanda Santiago;Edmond Chan;Pei-Qi Liu;Salvatore Orlando

  • A physical map of the mouse genome.

    Simon G Gregory;Mandeep Sekhon;Jacqueline Schein;Shaying Zhao

Frequent Co-Authors

Philip D. Gregory
Philip D. Gregory Sangamo BioSciences (United States)
Edward J. Rebar
Edward J. Rebar Sangamo BioSciences (United States)
Fyodor D. Urnov
Fyodor D. Urnov University of California, Berkeley
Luigi Naldini
Luigi Naldini Vita-Salute San Raffaele University
Jeffrey C. Miller
Jeffrey C. Miller Sangamo BioSciences (United States)
Lei Zhang
Lei Zhang Sangamo BioSciences (United States)
Chiara Bonini
Chiara Bonini Vita-Salute San Raffaele University
Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Laurence J.N. Cooper
Laurence J.N. Cooper The University of Texas MD Anderson Cancer Center
Hans Peter Kiem
Hans Peter Kiem Fred Hutchinson Cancer Research Center

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