1964 - Fellow of the Royal Society of Canada Academy of Science
His scientific interests lie mostly in Kinase, Alzheimer's disease, Cancer research, Biochemistry and Pharmacology. Charles D. Smith interconnects Ceramide, Signal transduction and Cell growth in the investigation of issues within Kinase. The various areas that he examines in his Ceramide study include Sphingosine, Sphingosine Kinase 2, Sphingosine kinase and Cell biology.
His Alzheimer's disease research includes elements of Hippocampal sclerosis, Biomarker and Neuroscience. He has included themes like Molecular biology, Cell culture, Paclitaxel and Colchicine in his Biochemistry study. His biological study spans a wide range of topics, including Apoptosis, Cell, Sorafenib and In vivo.
Charles D. Smith mainly investigates Disease, Internal medicine, Pharmacology, Cancer research and Biochemistry. His Disease study also includes
His studies examine the connections between Pharmacology and genetics, as well as such issues in Sphingosine kinase, with regards to Immunology. His Cancer research study also includes fields such as
Charles D. Smith mainly focuses on Artificial intelligence, Pattern recognition, Disease, Hyperintensity and Internal medicine. His research in Disease is mostly focused on Alzheimer's disease. His study in Alzheimer's disease is interdisciplinary in nature, drawing from both Cognitive reserve and Allele.
In his study, Pathology, Diffusion MRI, Fluid-attenuated inversion recovery and Default mode network is inextricably linked to White matter, which falls within the broad field of Hyperintensity. Charles D. Smith interconnects Endocrinology, Oncology and Cardiology in the investigation of issues within Internal medicine. His work carried out in the field of Neuroscience brings together such families of science as Neuropathology and Dementia.
Disease, Alzheimer's disease, Dementia, Neuroscience and Magnetic resonance imaging are his primary areas of study. His Alzheimer's disease research incorporates elements of Fractional anisotropy and Diffusion MRI. His Dementia study incorporates themes from Hippocampal sclerosis, Cohort and Cognitive test.
His Neuroscience study frequently draws connections between related disciplines such as Neuropathology. His research integrates issues of Internal medicine and Pathology in his study of Magnetic resonance imaging. His studies deal with areas such as Endocrinology and Protein phosphatase 1 as well as Internal medicine.
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Discovery and evaluation of inhibitors of human sphingosine kinase.
Kevin J. French;Randy S. Schrecengost;Brian D. Lee;Yan Zhuang.
Cancer Research (2003)
Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis
Y. Iturria-Medina;R. C. Sotero;P. J. Toussaint;J. M. Mateos-Pérez.
Nature Communications (2016)
Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.
C D Smith;B C Lane;I Kusaka;M W Verghese.
Journal of Biological Chemistry (1985)
Receptor-coupled activation of phosphoinositide-specific phospholipase C by an N protein
Charles D. Smith;C. Christine Cox;Ralph Snyderman.
Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.
Arati Sharma;Nishit R. Trivedi;Melissa A. Zimmerman;David A. Tuveson.
Cancer Research (2005)
Welwitindolinones, Unusual Alkaloids from the Blue-Green Algae Hapalosiphon welwitschii and Westiella intricata. Relationship to Fischerindoles and Hapalinodoles
Klemens Stratmann;Richard E. Moore;Rosanne Bonjouklian;Jack B. Deeter.
Journal of the American Chemical Society (1994)
Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2
Kevin J. French;Yan Zhuang;Lynn W. Maines;Peng Gao.
Journal of Pharmacology and Experimental Therapeutics (2010)
Antitumor activity of sphingosine kinase inhibitors
Kevin J. French;John J. Upson;Staci N. Keller;Yan Zhuang.
Journal of Pharmacology and Experimental Therapeutics (2006)
Cryptophycin: A New Antimicrotubule Agent Active against Drug-resistant Cells
Charles D. Smith;Xinqun Zhang;Susan L. Mooberry;Gregory M.L. Patterson.
Cancer Research (1994)
Reduction of TRAIL-Induced Mcl-1 and cIAP2 by c-Myc or Sorafenib Sensitizes Resistant Human Cancer Cells to TRAIL-Induced Death
M. Stacey Ricci;Seok Hyun Kim;Kazuhiro Ogi;John P. Plastaras.
Cancer Cell (2007)
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