What is he best known for?
The fields of study he is best known for:
- Internal medicine
- Gene
- Cancer
His scientific interests lie mostly in Kinase, Alzheimer's disease, Cancer research, Biochemistry and Pharmacology.
Charles D. Smith interconnects Ceramide, Signal transduction and Cell growth in the investigation of issues within Kinase.
The various areas that he examines in his Ceramide study include Sphingosine, Sphingosine Kinase 2, Sphingosine kinase and Cell biology.
His Alzheimer's disease research includes elements of Hippocampal sclerosis, Biomarker and Neuroscience.
He has included themes like Molecular biology, Cell culture, Paclitaxel and Colchicine in his Biochemistry study.
His biological study spans a wide range of topics, including Apoptosis, Cell, Sorafenib and In vivo.
His most cited work include:
- Discovery and evaluation of inhibitors of human sphingosine kinase. (541 citations)
- Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. (298 citations)
- Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. (297 citations)
What are the main themes of his work throughout his whole career to date?
Charles D. Smith mainly investigates Disease, Internal medicine, Pharmacology, Cancer research and Biochemistry.
His Disease study also includes
- Magnetic resonance imaging and related Pathology,
- Audiology together with Electroencephalography.
The various areas that he examines in his Internal medicine study include Endocrinology, Oncology and Cardiology.
His studies examine the connections between Pharmacology and genetics, as well as such issues in Sphingosine kinase, with regards to Immunology.
His Cancer research study also includes fields such as
- Sphingosine which is related to area like Ceramide and Cell growth,
- Kinase which connect with Phosphorylation.
His Alzheimer's disease research focuses on Dementia and how it connects with Neuropathology.
He most often published in these fields:
- Disease (13.03%)
- Internal medicine (12.56%)
- Pharmacology (11.37%)
What were the highlights of his more recent work (between 2015-2021)?
- Artificial intelligence (8.53%)
- Pattern recognition (5.45%)
- Disease (13.03%)
In recent papers he was focusing on the following fields of study:
Charles D. Smith mainly focuses on Artificial intelligence, Pattern recognition, Disease, Hyperintensity and Internal medicine.
His research in Disease is mostly focused on Alzheimer's disease.
His study in Alzheimer's disease is interdisciplinary in nature, drawing from both Cognitive reserve and Allele.
In his study, Pathology, Diffusion MRI, Fluid-attenuated inversion recovery and Default mode network is inextricably linked to White matter, which falls within the broad field of Hyperintensity.
Charles D. Smith interconnects Endocrinology, Oncology and Cardiology in the investigation of issues within Internal medicine.
His work carried out in the field of Neuroscience brings together such families of science as Neuropathology and Dementia.
Between 2015 and 2021, his most popular works were:
- Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer's pathology. (124 citations)
- "New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS). (88 citations)
- A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors. (72 citations)
In his most recent research, the most cited papers focused on:
- Internal medicine
- Gene
- Cancer
Disease, Alzheimer's disease, Dementia, Neuroscience and Magnetic resonance imaging are his primary areas of study.
His Alzheimer's disease research incorporates elements of Fractional anisotropy and Diffusion MRI.
His Dementia study incorporates themes from Hippocampal sclerosis, Cohort and Cognitive test.
His Neuroscience study frequently draws connections between related disciplines such as Neuropathology.
His research integrates issues of Internal medicine and Pathology in his study of Magnetic resonance imaging.
His studies deal with areas such as Endocrinology and Protein phosphatase 1 as well as Internal medicine.
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