World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
102
Citations
33203
World Ranking
7749
National Ranking
4036

Research.com Recognitions

  • 1964 - Fellow of the Royal Society of Canada Academy of Science

Overview

Charles D. Smith is affiliated with the University of Kentucky in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with a notable focus on Molecular Biology and Cancer Research within these disciplines. The work also addresses several specialized subfields such as Immunology, Epidemiology, and Infectious Diseases.

The scientist's recent work has concentrated on areas including:

  • Sphingolipid Metabolism and Signaling
  • Cancer, Hypoxia, and Metabolism
  • Autophagy in Disease and Therapy
  • Phagocytosis and Immune Regulation
  • Cell death mechanisms and regulation
  • COVID-19 Clinical Research Studies
  • Radioactive element chemistry and processing

Charles D. Smith has contributed to multiple publications, often collaborating with frequent co-authors Lynn W. Maines and Staci N. Keller, among others including Randy S. Schrecengost, Cecelia L. Green, and Ryan A. Smith.

The scientist's notable recent papers include:

  • Recent Progress in the Development of Opaganib for the Treatment of Covid-19, 2022, Drug Design Development and Therapy
  • Support loading effects on the performance of an extraction chromatographic resin: Toward improved separation of trivalent lanthanides, 2020, Talanta
  • Opaganib (ABC294640) Induces Immunogenic Tumor Cell Death and Enhances Checkpoint Antibody Therapy, 2023, International Journal of Molecular Sciences
  • Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA), 2020, Cancer Biology & Therapy
  • Opaganib Protects against Radiation Toxicity: Implications for Homeland Security and Antitumor Radiotherapy, 2022, International Journal of Molecular Sciences

Charles D. Smith publishes frequently in the following scientific venues:

  • International Journal of Molecular Sciences
  • Drug Design Development and Therapy
  • Talanta
  • Cancer Biology & Therapy
  • International Journal of Nephrology and Renovascular Disease

An award associated with Charles D. Smith is the Fellowship of the Royal Society of Canada granted in 1964, acknowledged by the Academy of Science.

Best Publications

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

    Y. Iturria-Medina;R. C. Sotero;P. J. Toussaint;J. M. Mateos-Pérez

  • Discovery and evaluation of inhibitors of human sphingosine kinase.

    Kevin J. French;Randy S. Schrecengost;Brian D. Lee;Yan Zhuang

  • Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease

    Joseph L. Price;Daniel W. McKeel;Virginia D. Buckles;Catherine M. Roe

  • Neuropathologic substrate of mild cognitive impairment.

    William R. Markesbery;Frederick A. Schmitt;Richard J. Kryscio;Daron G. Davis

  • Neural substrates of facial emotion processing using fMRI.

    Marilyn L. Kesler;West;Anders H. Andersen;Charles D. Smith

  • Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease

    Pamela Sparks Stein;Michelle J. Steffen;Charles Smith;Gregory Jicha

  • Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.

    Arati Sharma;Nishit R. Trivedi;Melissa A. Zimmerman;David A. Tuveson

  • Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies

    Peter T. Nelson;Elizabeth Head;Frederick A. Schmitt;Paulina R. Davis

  • Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

    Kevin J. French;Yan Zhuang;Lynn W. Maines;Peng Gao

  • Antitumor activity of sphingosine kinase inhibitors

    Kevin J. French;John J. Upson;Staci N. Keller;Yan Zhuang

  • Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer's pathology.

    Taylor W. Schmitz;R. Nathan Spreng;Michael W. Weiner;Paul Aisen

  • Cryptophycin: A New Antimicrotubule Agent Active against Drug-resistant Cells

    Charles D. Smith;Xinqun Zhang;Susan L. Mooberry;Gregory M.L. Patterson

  • Reduction of TRAIL-Induced Mcl-1 and cIAP2 by c-Myc or Sorafenib Sensitizes Resistant Human Cancer Cells to TRAIL-Induced Death

    M. Stacey Ricci;Seok Hyun Kim;Kazuhiro Ogi;John P. Plastaras

  • Low sensitivity in clinical diagnoses of dementia with Lewy bodies

    Peter T. Nelson;Gregory A. Jicha;Richard J. Kryscio;Erin L. Abner

  • Hippocampal sclerosis in advanced age: clinical and pathological features

    Peter T. Nelson;Frederick A. Schmitt;Yushun Lin;Erin L. Abner

  • Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity.

    Don M. Gash;Kathryn Rutland;Naomi L. Hudson;Patrick G. Sullivan

  • Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations.

    Mark S. Forman;Ian R. Mackenzie;Nigel J. Cairns;Eric Swanson

  • Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

    Giovanni Coppola;Subashchandrabose Chinnathambi;Jason Ji Yong Lee;Beth A. Dombroski

  • Altered brain activation in cognitively intact individuals at high risk for Alzheimer’s disease

    C.D. Smith;A.H. Andersen;R.J. Kryscio;F.A. Schmitt

Frequent Co-Authors

Gregory A. Jicha
Gregory A. Jicha University of Kentucky
Frederick A. Schmitt
Frederick A. Schmitt University of Kentucky
Richard J. Kryscio
Richard J. Kryscio University of Kentucky
Peter T. Nelson
Peter T. Nelson University of Kentucky
William R. Markesbery
William R. Markesbery University of Kentucky
Linda J. Van Eldik
Linda J. Van Eldik University of Kentucky
Brian T. Gold
Brian T. Gold University of Kentucky
Wafik S. El-Deiry
Wafik S. El-Deiry Brown University
Robert C. Green
Robert C. Green Brigham and Women's Hospital
Andrew S. Kraft
Andrew S. Kraft University of Arizona

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