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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
32246
World Ranking
11653
National Ranking
5013

Overview

Joyce J. Repa is affiliated with The University of Texas Southwestern Medical Center in the United States, contributing research primarily in the fields of medicine and biochemistry, genetics, and molecular biology. Their work spans a range of topics including lysosomal storage disorders and sphingolipid metabolism and signaling.

Their research outputs include publications in various scientific journals with a focus on physiology, molecular biology, epidemiology, immunology, and public health. Notable publication venues include:

  • Nature
  • Steroids
  • Lipids

Recent papers illustrate a focus on metabolic processes and neurological disease mechanisms. Key publications are:

  • Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C, 2021, Nature
  • Delineation of metabolic responses of Npc1 mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-β-cyclodextrin, 2020, Steroids
  • Molecular markers of brain cholesterol homeostasis are unchanged despite a smaller brain mass in a mouse model of cholesteryl ester storage disease, 2021, Lipids

Their work addresses topics such as lysosomal storage disorders research, sphingolipid metabolism and signaling, cytomegalovirus and herpesvirus research, interferon and immune responses, mosquito-borne diseases and control, carbohydrate chemistry and synthesis, and cellular transport and secretion.

Joyce J. Repa frequently collaborates with several other researchers including:

  • Charina M. Ramirez
  • Adam M. Lopez
  • Stephen D. Turley
  • Tingting Chu
  • Xintao Tu

These collaborations have contributed to a multidisciplinary approach within their main fields of study, integrating biochemistry, physiology, and immunology aspects to investigate complex biological and pathological processes.

Best Publications

  • Identification of a Nuclear Receptor for Bile Acids

    Makoto Makishima;Arthur Y. Okamoto;Joyce J. Repa;Hua Tu

  • Nuclear receptors and lipid physiology: opening the X-files.

    Ajay Chawla;Joyce J. Repa;Ronald M. Evans;David J. Mangelsdorf

  • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

    Joyce J. Repa;Guosheng Liang;Jiafu Ou;Yuriy Bashmakov

  • Role of LXRs in control of lipogenesis

    Joshua R. Schultz;Hua Tu;Alvin Luk;Joyce J. Repa

  • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

    Takeshi Inagaki;Mihwa Choi;Antonio Moschetta;Li Peng

  • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.

    Timothy T. Lu;Makoto Makishima;Joyce J. Repa;Kristina Schoonjans

  • Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

    Joyce Repa;Stephen D Turley;J. M A Lobaccaro;J. Medina

  • Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β

    Joyce J. Repa;Knut E. Berge;Chris Pomajzl;James A. Richardson

  • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.

    Takeshi Inagaki;Antonio Moschetta;Youn Kyoung Lee;Li Peng

  • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

    Joyce J. Repa;David J. Mangelsdorf

  • The power of real-time PCR.

    Mark A. Valasek;Joyce J. Repa

  • LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

    Bryan A. Laffitte;Joyce J. Repa;Sean B. Joseph;Damien C. Wilpitz

  • Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis

    Kosaku Uyeda;Joyce J. Repa

  • The Liver X Receptor (LXR) and Hepatic Lipogenesis THE CARBOHYDRATE-RESPONSE ELEMENT-BINDING PROTEIN IS A TARGET GENE OF LXR

    Ji Young Cha;Joyce J. Repa

  • The liver X receptor gene team: potential new players in atherosclerosis.

    Joyce J. Repa;David J. Mangelsdorf

  • Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1−/− mouse

    Benny Liu;Stephen D. Turley;Dennis K. Burns;Anna M. Miller

  • Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism.

    Timothy T. Lu;Joyce J. Repa;David J. Mangelsdorf

  • Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

    Asha Venkateswaran;Joyce J. Repa;Jean Marc A Lobaccaro;Amy Bronson

  • Regulation of Lipoprotein Lipase by the Oxysterol Receptors, LXRα and LXRβ

    Yuan Zhang;Joyce J. Repa;Karine Gauthier;David J. Mangelsdorf

  • Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor

    Thierry Claudel;Mark D. Leibowitz;Catherine Fiévet;Anne Tailleux

Frequent Co-Authors

David J. Mangelsdorf
David J. Mangelsdorf The University of Texas Southwestern Medical Center
John M. Dietschy
John M. Dietschy The University of Texas Southwestern Medical Center
Steven A. Kliewer
Steven A. Kliewer The University of Texas Southwestern Medical Center
James A. Richardson
James A. Richardson The University of Texas Southwestern Medical Center
Jeffrey M. Zigman
Jeffrey M. Zigman The University of Texas Southwestern Medical Center
Weiping Han
Weiping Han Institute of Molecular and Cell Biology
Antonio Moschetta
Antonio Moschetta University of Bari Aldo Moro
Kosaku Uyeda
Kosaku Uyeda The University of Texas Southwestern Medical Center
Johan Auwerx
Johan Auwerx École Polytechnique Fédérale de Lausanne
Helen H. Hobbs
Helen H. Hobbs The University of Texas Southwestern Medical Center

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