World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
63
Citations
15949
World Ranking
8337
National Ranking
2408

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Olaf Wiest is affiliated with the University of Notre Dame in the United States and conducts research primarily within the fields of Biochemistry, Genetics, and Molecular Biology. Their published work spans several subfields including Molecular Biology, Materials Chemistry, Organic Chemistry, Computational Theory and Mathematics, and Artificial Intelligence.

Their research topics highlight a focus on Computational Drug Discovery Methods, Machine Learning in Materials Science, Plant Biochemistry and Biosynthesis, Ubiquitin and Proteasome Pathways, Viral Infections and Outbreaks Research, Protein Structure and Dynamics, as well as Crystallization and Solubility Studies.

Wiest's recent papers illustrate a diverse range of scientific inquiries. Notable publications include:

  • "EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma" (2021), published in Cancer Discovery
  • "On the use of real-world datasets for reaction yield prediction" (2023), published in Chemical Science
  • "What can Large Language Models do in chemistry? A comprehensive benchmark on eight tasks" (2023), published in arXiv (Cornell University)
  • "Large Language Model based Multi-Agents: A Survey of Progress and Challenges" (2024), published in arXiv (Cornell University)
  • "Negative Data in Data Sets for Machine Learning Training" (2023), published in Organic Letters

Frequent publication venues for Olaf Wiest reflect a multidisciplinary engagement, featuring contributions in:

  • arXiv (Cornell University)
  • The Journal of Organic Chemistry
  • Biophysical Journal
  • The Cambridge Structural Database
  • Organic Letters

Collaborative work plays a significant role in Wiest's research. Frequent coauthors include Paul Helquist, Per-Ola Norrby, Nitesh V. Chawla, Xiangliang Zhang, and Brandon L. Ashfeld.

Olaf Wiest has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2012, indicating peer recognition within the scientific community.

Best Publications

  • Selective inhibition of BET bromodomains.

    Panagis Filippakopoulos;Jun Qi;Sarah Picaud;Yao Shen

  • A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

    Alassane Mbengue;Souvik Bhattacharjee;Trupti Pandharkar;Haining Liu

  • Quantum Mechanical Methods and the Interpretation and Prediction of Pericyclic Reaction Mechanisms

    Olaf Wiest;Daniel C. Montiel;K. N. Houk

  • Toward selective histone deacetylase inhibitor design: homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases.

    Di-Fei Wang;Paul Helquist;Norbert L Wiech;Olaf Wiest

  • Direct Visible-Light-Excited Asymmetric Lewis Acid Catalysis of Intermolecular [2+2] Photocycloadditions.

    Xiaoqiang Huang;Taylor R. Quinn;Klaus Harms;Richard D. Webster

  • Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

    Nina H. Pipalia;Casey C. Cosner;Amy Huang;Anamitra Chatterjee

  • DENSITY FUNCTIONAL THEORY ISOTOPE EFFECTS AND ACTIVATION ENERGIES FOR THE COPE AND CLAISEN REARRANGEMENTS

    Olaf Wiest;Kersey A. Black;K. N. Houk

  • Mechanism, Reactivity, and Selectivity in Palladium-Catalyzed Redox-Relay Heck Arylations of Alkenyl Alcohols

    Liping Xu;Margaret J. Hilton;Xinhao Zhang;Per Ola Norrby;Per Ola Norrby

  • On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors.

    Di-Fei Wang;Olaf Wiest;Paul Helquist;Hsuan-Yin Lan-Hargest

  • Synergy of combining sonolysis and photocatalysis in the degradation and mineralization of chlorinated aromatic compounds.

    Julie Peller;Olaf Wiest;Prashant V. Kamat

  • Theoretical Studies of Mixed-Valence Transition Metal Complexes for Molecular Computing

    Sonja B. Braun-Sand;Olaf Wiest

  • EP300 selectively controls the enhancer landscape of MYCN-amplified neuroblastoma.

    Adam D Durbin;Tingjian Wang;Virangika K Wimalasena;Mark W Zimmerman

  • Hydroxyl radical's role in the remediation of a common herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D)

    Julie Peller;Olaf Wiest;Prashant V. Kamat

  • Synthesis of primary aryl amines through a copper-assisted aromatic substitution reaction with sodium azide.

    John T Markiewicz;Olaf Wiest;Paul Helquist

  • Chemical genomics reveals histone deacetylases are required for core regulatory transcription.

    Berkley E Gryder;Lei Wu;Girma M Woldemichael;Silvia Pomella

  • Few-Shot Graph Learning for Molecular Property Prediction

    Zhichun Guo;Chuxu Zhang;Wenhao Yu;John Herr

  • Structural Origin of Selectivity in Class II-Selective Histone Deacetylase Inhibitors

    Guillermina Estiu;Edward Greenberg;Christopher B. Harrison;Nicholas P. Kwiatkowski

  • Rapid virtual screening of enantioselective catalysts using CatVS

    Anthony R. Rosales;Jessica Wahlers;Elaine Limé;Rebecca E. Meadows

  • PHOTOCHEMICALLY INDUCED RADICAL CATION DIELS-ALDER REACTION OF INDOLE AND ELECTRON-RICH DIENES

    Andreas Gieseler;Eberhard Steckhan;Olaf Wiest;Falk Knoch

  • Chiral Hypervalent Organo‐Iodine(III) Compounds

    Urs H. Hirt;Martin F. H. Schuster;Andrew N. French;Olaf G. Wiest

  • Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.

    Albert A. Bowers;Nathan West;Tenaya L. Newkirk;Annie E. Troutman-Youngman

  • Synthesis and Conformation-Activity Relationships of the Peptide Isosteres of FK228 and Largazole

    Albert A. Bowers;Thomas J. Greshock;Nathan West;Guillermina Estiu

  • Prediction of enantioselectivity in rhodium catalyzed hydrogenations.

    Patrick J. Donoghue;Paul Helquist;Per-Ola Norrby;Olaf Wiest

Frequent Co-Authors

Paul Helquist
Paul Helquist University of Notre Dame
Per-Ola Norrby
Per-Ola Norrby AstraZeneca (Sweden)
Yun-Dong Wu
Yun-Dong Wu Peking University
Robert M. Williams
Robert M. Williams Colorado State University
James E. Bradner
James E. Bradner Amgen (United States)
Matthew S. Sigman
Matthew S. Sigman University of Utah
Eric Meggers
Eric Meggers Philipp University of Marburg
Frederick R. Maxfield
Frederick R. Maxfield Cornell University
Prashant V. Kamat
Prashant V. Kamat University of Notre Dame
Robert V. Stahelin
Robert V. Stahelin Purdue University West Lafayette

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