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Chemistry

D-Index
49
Citations
7719
World Ranking
14933
National Ranking
3808

Overview

Paul Helquist is affiliated with the University of Notre Dame in the United States. Their research spans various fields within biochemistry, genetics, and molecular biology, with a strong focus on molecular biology, materials chemistry, physiology, organic chemistry, and computational theory and mathematics.

Their scientific contributions include work on diverse topics, notably:

  • Plant biochemistry and biosynthesis
  • Computational drug discovery methods
  • Protein structure and dynamics
  • Machine learning in materials science
  • Lysosomal storage disorders research
  • Enzyme structure and function
  • Microbial metabolism and applications

Helquist has published extensively, with frequent appearances in several scientific journals. The main publication venues include:

  • Biophysical Journal
  • The Journal of Organic Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Cambridge Structural Database
  • Organic Letters

Among Helquist's recent papers are:

  • "Negative Data in Data Sets for Machine Learning Training," 2023, Organic Letters
  • "Negative Data in Data Sets for Machine Learning Training," 2023, The Journal of Organic Chemistry
  • "Transition State Force Field for the Asymmetric Redox-Relay Heck Reaction," 2020, Journal of the American Chemical Society
  • "Interplay of Computation and Experiment in Enantioselective Catalysis: Rationalization, Prediction, andCorrection?," 2023, ACS Catalysis
  • "HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts," 2021, Journal of Lipid Research

Helquist has collaborated frequently with several researchers, including:

  • Olaf Wiest
  • Per-Ola Norrby
  • Cynthia V. Stauffacher
  • C.N. Steussy
  • Anthony R. Rosales

Best Publications

  • Reaction of aryl and vinyl halides with zerovalent nickel - preparative aspects and the synthesis of alnusone

    M. F. Semmelhack;Paul Helquist;L. D. Jones;Leonard Keller;Leonard Keller

  • Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition

    Yasuyuki Miyake;Jeremy J Keusch;Longlong Wang;Makoto Saito

  • Synthesis with Zerovalent Nickel. Coupling of Alkenyl Halides with Bis(1,5-cyclooctadiene)nickel(0)

    M. F. Semmelhack;P. M. Helquist;J. D. Gorzynski

  • Toward selective histone deacetylase inhibitor design: homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases.

    Di-Fei Wang;Paul Helquist;Norbert L Wiech;Olaf Wiest

  • Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

    Nina H. Pipalia;Casey C. Cosner;Amy Huang;Anamitra Chatterjee

  • On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors.

    Di-Fei Wang;Olaf Wiest;Paul Helquist;Hsuan-Yin Lan-Hargest

  • Synthesis of primary aryl amines through a copper-assisted aromatic substitution reaction with sodium azide.

    John T Markiewicz;Olaf Wiest;Paul Helquist

  • Rapid virtual screening of enantioselective catalysts using CatVS

    Anthony R. Rosales;Jessica Wahlers;Elaine Limé;Rebecca E. Meadows

  • An efficient, palladium-catalyzed route to protected allylic amines

    Richard D. Connell;Tobias Rein;Bjoern Aakermark;Paul Helquist

  • Selective oxidation of benzylic and allylic alcohols using Mn(OAc)3/catalytic 2,3-dichloro-5,6-dicyano-1,4-benzoquinone.

    Casey C. Cosner;Pablo J. Cabrera;Katherine M. Byrd;Asia M. Adams Thomas

  • Prediction of enantioselectivity in rhodium catalyzed hydrogenations.

    Patrick J. Donoghue;Paul Helquist;Per-Ola Norrby;Olaf Wiest

  • Highly stereoselective synthesis of trisubstituted olefins via addition of alkylcopper complexes to acetylenes

    Anthony Marfat;Paul R. McGuirk;Paul Helquist

  • Palladium‐ and Nickel‐Catalyzed Alkenylation of Enolates

    Tobias Ankner;Casey C. Cosner;Paul Helquist;Paul Helquist

  • Functionalized oxazoles from rhodiumi-catalyzed reaction of dimethyl diazomalonate with nitriles

    Richard Connell;Frank Scavo;Paul Helquist;Björn Åkermark

  • Thiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann−Pick Type C Disease Therapeutics

    Anton I. Rosenbaum;Casey C. Cosner;Christopher J. Mariani;Frederick R. Maxfield

  • Inhibition of Histone Deacetylases: A Pharmacological Approach to the Treatment of Non-Cancer Disorders

    Norbert L. Wiech;Jed F. Fisher;Paul Helquist;Olaf Wiest

  • Intramolecular hydroamination of aminoalkynes with silver-phenanthroline catalysts.

    Jeffrey M. Carney;Patrick J. Donoghue;William M. Wuest;Olaf Wiest

  • Molecular Mechanics Predictions and Experimental Testing of Asymmetric Palladium-Catalyzed Allylation Reactions Using New Chiral Phenanthroline Ligands

    Unknown

  • Cyclopentene and cyclohexene annulation via copper-catalyzed conjugate addition of acetal-containing Grignard reagents

    Swati A. Bal;Anthony Marfat;Paul Helquist

  • Development of a Q2MM Force Field for the Asymmetric Rhodium Catalyzed Hydrogenation of Enamides.

    Patrick J. Donoghue;Paul Helquist;Per-Ola Norrby;Olaf Wiest

  • Enantioselective Synthesis of Salmeterol via Asymmetric Borane Reduction.

    Robert Hett;Ragnar Stare;Paul Helquist

Frequent Co-Authors

Olaf Wiest
Olaf Wiest University of Notre Dame
Per-Ola Norrby
Per-Ola Norrby AstraZeneca (Sweden)
Martin Tenniswood
Martin Tenniswood University at Albany, State University of New York
Björn Åkermark
Björn Åkermark Stockholm University
Frederick R. Maxfield
Frederick R. Maxfield Cornell University
Marvin J. Miller
Marvin J. Miller University of Notre Dame
Martin F. Semmelhack
Martin F. Semmelhack Princeton University
Qian Peng
Qian Peng Chinese Academy of Sciences
Patrick Matthias
Patrick Matthias Friedrich Miescher Institute
Daniel Hess
Daniel Hess Friedrich Miescher Institute

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