World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
22964
World Ranking
9995
National Ranking
267

Overview

Trevor J. Biden is affiliated with the Garvan Institute of Medical Research in Australia and has a research focus spanning medicine, biochemistry, genetics, and molecular biology. Their work concentrates primarily on the fields of pancreatic function and diabetes, autophagy in disease and therapy, and related metabolic disorders.

The scientist's recent publications emphasize various aspects of metabolic regulation, cellular pathways, and disease mechanisms. Notable papers include:

  • SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control, 2020, Science Translational Medicine
  • A Selective Look at Autophagy in Pancreatic β-Cells, 2021, Diabetes
  • Short-term inhibition of autophagy benefits pancreatic β-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding, 2020, Molecular Metabolism
  • Heparan sulfate proteoglycans in beta cells provide a critical link between endoplasmic reticulum stress, oxidative stress and type 2 diabetes, 2021, PLoS ONE
  • β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling, 2023, iScience

Frequent co-authors collaborating with Trevor J. Biden include Le May Thai, Nancy Sue, Chenxu Yan, Yan-Chuan Shi, and Kwan Yi Chu. These collaborations suggest an interdisciplinary network within cellular metabolism, diabetes research, and molecular biology.

The primary publication venues reflect the diverse nature of their studies and include Molecular Metabolism, Science Translational Medicine, Diabetes, PLoS ONE, and iScience.

Their main fields of study encompass:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Subfields of study as indicated by their research activities are:

  • Surgery
  • Molecular Biology
  • Cell Biology
  • Epidemiology
  • Pharmacology

The key topics of Trevor J. Biden's research portfolio include:

  • Pancreatic function and diabetes
  • Autophagy in Disease and Therapy
  • Cannabis and Cannabinoid Research
  • Diabetes and associated disorders
  • Endoplasmic Reticulum Stress and Disease
  • Metabolism, Diabetes, and Cancer
  • Glycosylation and Glycoproteins Research

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes.

    D. R. Laybutt;A. M. Preston;M. C. Åkerfeldt;J. G. Kench

  • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

    Carsten Schmitz-Peiffer;Denby L. Craig;Trevor J. Biden

  • Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.

    M Prentki;T J Biden;D Janjic;R F Irvine

  • Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

    L.A. Selbie;C Schmitz-Peiffer;Y Sheng;T.J. Biden

  • Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.

    Carsten Schmitz-Peiffer;Carol L Browne;Nicholas D Oakes;Allan Watkinson

  • Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation

    Jean Buteau;Sylvain Foisy;Christopher J. Rhodes;Lee Carpenter

  • Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.

    L Vallar;T J Biden;C B Wollheim

  • Structural subtypes of the dopamine D2 receptor are functionally distinct: expression of the cloned D2A and D2B subtypes in a heterologous cell line.

    G Hayes;T J Biden;L A Selbie;J Shine

  • Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus.

    Trevor J. Biden;Ebru Boslem;Kwan Yi Chu;Nancy Sue

  • Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells

    T J Biden;M Prentki;R F Irvine;M J Berridge

  • Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell Function

    Anna K. Busch;Damien Cordery;Gareth S. Denyer;Trevor J. Biden

  • Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells.

    T J Biden;C B Wollheim

  • Ca2+-mediated generation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine.

    T.J. Biden;B. Peter-Riesch;W. Schlegel;C.B. Wollheim

  • Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis

    Anna K. Busch;Ebru Gurisik;Ebru Gurisik;Ebru Gurisik;Damien V. Cordery;Michelle Sudlow

  • Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.

    A. M. Preston;A. M. Preston;A. M. Preston;E. Gurisik;E. Gurisik;C. Bartley;D. R. Laybutt;D. R. Laybutt

  • Second messenger function of inositol 1,4,5-trisphosphate. Early changes in inositol phosphates, cytosolic Ca2+, and insulin release in carbamylcholine-stimulated RINm5F cells.

    C B Wollheim;T J Biden

  • A Role for Protein Phosphatase 2A–Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate

    Rosanna Cazzolli;Lee Carpenter;Trevor J. Biden;Carsten Schmitz-Peiffer

  • G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

    M. Ferdaoussi;V. Bergeron;B. Zarrouki;J. Kolic

  • P-101: Alterations in the expression and cellular localization of protein kinase C isozymes are associated with insulin resistance in skeletal muscle of the high-fat-fed rat

    Carsten Schmitz-Peiffer;Carol L. Browne;Nicholas D. Oakes;Allan Watkinson

Frequent Co-Authors

Gregory J. Cooney
Gregory J. Cooney University of Sydney
Peter J. Meikle
Peter J. Meikle Baker IDI Heart and Diabetes Institute
David E. James
David E. James University of Sydney
Nigel Turner
Nigel Turner University of New South Wales
Claes B. Wollheim
Claes B. Wollheim University of Geneva
Michael Leitges
Michael Leitges University of Oslo
Edward W. Kraegen
Edward W. Kraegen Garvan Institute of Medical Research
Mark A. Febbraio
Mark A. Febbraio Monash University
John Shine
John Shine Garvan Institute of Medical Research
Marc Prentki
Marc Prentki University of Montreal

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