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Neuroscience

D-Index
69
Citations
18965
World Ranking
2608
National Ranking
1234

Overview

Dennis J. Dlugos is affiliated with the Children's Hospital of Philadelphia in the United States. Their research spans multiple domains within medicine, with a primary focus on epilepsy and related neurological conditions. They have contributed extensively to knowledge in epilepsy research and treatment, pharmacological effects and toxicity studies, genomics and rare diseases, genetics and neurodevelopmental disorders, neonatal and fetal brain pathology, pharmaceutical studies and practices, and neuroscience and neuropharmacology research.

The scientist has published frequently in several prominent venues. The main publication venues include:

  • Neurology
  • Epilepsia
  • Epilepsia Open
  • Brain
  • The American Journal of Human Genetics

Their work encompasses broad fields of study such as medicine, with significant subfields in psychiatry and mental health, pediatrics, perinatology and child health, genetics, cellular and molecular neuroscience, and molecular biology.

Dlugos has collaborated regularly with several researchers, often co-authoring papers. Frequent co-authors include:

  • Jacqueline A. French
  • Michael R. Sperling
  • James W. Wheless
  • Adrián L. Rabinowicz
  • Enrique Carrazana

Among the recent publications authored or co-authored by Dlugos are:

  • "GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture," published in 2023 in Nature Genetics
  • "Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17,458 subjects," published in 2020 in Brain
  • "A phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in pediatric patients with Dravet syndrome or Lennox-Gastaut syndrome (ELEKTRA)," published in 2022 in Epilepsia
  • "Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy," published in 2021 in Epilepsia
  • "Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals," published in 2021 in The American Journal of Human Genetics

Best Publications

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • De novo mutations in epileptic encephalopathies

    Andrew S. Allen;Samuel F. Berkovic;Patrick Cossette;Norman Delanty

  • Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

    Elizabeth A Thiele;Eric D Marsh;Jacqueline A French;Maria Mazurkiewicz-Beldzinska

  • Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study.

    Jacqueline A French;John A Lawson;Zuhal Yapici;Hiroko Ikeda

  • Ethosuximide, Valproic Acid, and Lamotrigine in Childhood Absence Epilepsy

    Tracy A. Glauser;Tracy A. Glauser;Avital Cnaan;Shlomo Shinnar;Deborah G. Hirtz

  • Infantile spasms: A U.S. consensus report

    John M. Pellock;Richard Hrachovy;Shlomo Shinnar;Tallie Z. Baram

  • Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

    Bassel Abou-Khalil;Pauls Auce;Andreja Avbersek;Melanie Bahlo

  • Ethosuximide, Valproic Acid and Lamotrigine in Childhood Absence Epilepsy: Initial Monotherapy Outcomes at 12 months

    Tracy A. Glauser;Avital Cnaan;Shlomo Shinnar;Deborah G. Hirtz

  • Human and automated detection of high-frequency oscillations in clinical intracranial EEG recordings.

    Andrew B. Gardner;Greg A. Worrell;Eric Marsh;Dennis Dlugos

  • KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine.

    Carol J. Milligan;Melody Li;Elena V. Gazina;Sarah E. Heron

  • De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies

    Candace T. Myers;Jacinta M. McMahon;Amy L. Schneider;Slavé Petrovski;Slavé Petrovski

  • Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies

    Richard Anney;A. Avbersek;D. Balding;L. Baum

  • A roadmap for precision medicine in the epilepsies

    S. F. Berkovic;I. E. Scheffer;S. Petrou;N. Delanty

  • Targeted treatment of migrating partial seizures of infancy with quinidine.

    David Bearden;Alanna Strong;Jessica Ehnot;Marissa DiGiovine

  • Nonconvulsive seizures are common in critically ill children

    N.S. Abend;A.M. Gutierrez-Colina;A.A. Topjian;H. Zhao

  • Electroencephalographic monitoring during hypothermia after pediatric cardiac arrest

    N. S. Abend;A. Topjian;R. Ichord;S. T. Herman

  • Response to treatment in a prospective national infantile spasms cohort

    Kelly G. Knupp;Jason Coryell;Katherine C. Nickels;Nicole Ryan

  • Response to first drug trial predicts outcome in childhood temporal lobe epilepsy

    Dennis J. Dlugos;Mary D. Sammel;Brian L. Strom;John T. Farrar

  • Ultra-rare genetic variation in common epilepsies: a case-control sequencing study.

    Andrew S Allen;Susannah T Bellows;Samuel F Berkovic;Joshua Bridgers

  • Electrographic status epilepticus is associated with mortality and worse short-term outcome in critically ill children.

    Alexis A. Topjian;Ana M. Gutierrez-Colina;Sarah M. Sanchez;Robert A. Berg

  • Treatment of Refractory Status Epilepticus: Literature Review and a Proposed Protocol

    Nicholas S. Abend;Nicholas S. Abend;Dennis J. Dlugos;Dennis J. Dlugos

  • Erratum: De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies (American Journal of Human Genetics (2014) 95(4) (360–370)(S0002929714003838)(10.1016/j.ajhg.2014.08.013))

    Silke Appenzeller;Rudi Balling;Nina Barisic;Stéphanie Baulac

Frequent Co-Authors

Nicholas S. Abend
Nicholas S. Abend University of Pennsylvania
Jacqueline A. French
Jacqueline A. French New York University
Ingrid E. Scheffer
Ingrid E. Scheffer University of Melbourne
Samuel F. Berkovic
Samuel F. Berkovic University of Melbourne
Daniel H. Lowenstein
Daniel H. Lowenstein University of California, San Francisco
Erin L. Heinzen
Erin L. Heinzen University of North Carolina at Chapel Hill
Norman Delanty
Norman Delanty Beaumont Hospital
Slavé Petrovski
Slavé Petrovski AstraZeneca (United Kingdom)
Anthony G Marson
Anthony G Marson University of Liverpool
Ingo Helbig
Ingo Helbig Children's Hospital of Philadelphia

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