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Chemistry

D-Index
46
Citations
8815
World Ranking
15939
National Ranking
1166

Overview

Harald Hübner is affiliated with the University of Erlangen-Nuremberg in Germany. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with a significant involvement in neuroscience. The subfields of their work include molecular biology, cellular and molecular neuroscience, spectroscopy, materials chemistry, and radiology, nuclear medicine and imaging.

The main topics addressed in Hübner's research cover receptor mechanisms and signaling, neuropeptides and animal physiology, pharmacological receptor mechanisms and effects, monoclonal and polyclonal antibodies research, photochromic and fluorescence chemistry, mass spectrometry techniques and applications, and chemical synthesis and analysis.

Hübner has contributed to several recent scientific papers, illustrating a focus on receptor biology and pharmacology. Notable publications include:

  • Structure-based discovery of nonopioid analgesics acting through the α 2A -adrenergic receptor, 2022, Science
  • Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR, 2020, Cell Research
  • An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor, 2020, Nature Chemical Biology
  • Structure-Based Evolution of G Protein-Biased μ-Opioid Receptor Agonists, 2022, Angewandte Chemie International Edition
  • Structure-based development of a subtype-selective orexin 1 receptor antagonist, 2020, Proceedings of the National Academy of Sciences

Frequent coauthors collaborating with Hübner include Peter Gmeiner, Dorothée Weikert, Brian K. Kobilka, Jonas Kaindl, and Stefan Löber. These collaborations reflect a network within molecular pharmacology and receptor research.

The scientist's research has been published repeatedly in journals such as the Journal of Medicinal Chemistry, bioRxiv (Cold Spring Harbor Laboratory), Angewandte Chemie International Edition, Nature Communications, and Angewandte Chemie. These journals correspond with the fields of study and research topics that dominate Hübner's academic output.

Best Publications

  • Activation and allosteric modulation of a muscarinic acetylcholine receptor

    Andrew C. Kruse;Aaron M. Ring;Aashish Manglik;Jianxin Hu

  • Conjugated Enynes as Nonaromatic Catechol Bioisosteres: Synthesis, Binding Experiments, and Computational Studies of Novel Dopamine Receptor Agonists Recognizing Preferentially the D3 Subtype

    Harald Hübner;Christian Haubmann;Wolfgang Utz;Peter Gmeiner

  • Interactive SAR Studies: Rational Discovery of Super-Potent and Highly Selective Dopamine D3 Receptor Antagonists and Partial Agonists

    Laura Bettinetti;Karin Schlotter;Harald Hübner;Peter Gmeiner

  • Labeling and Glycosylation of Peptides Using Click Chemistry: A General Approach to 18F‐Glycopeptides as Effective Imaging Probes for Positron Emission Tomography

    Simone Maschauer;Jürgen Einsiedel;Roland Haubner;Carsten Hocke

  • Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).

    Stefan Löber;Harald Hübner;Wolfgang Utz;Peter Gmeiner

  • Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.

    Stefan Löber;Harald Hübner;Peter Gmeiner

  • Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

    Xinyu Xu;Jonas Kaindl;Mary J. Clark;Harald Hübner

  • Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates

    Stefan Löber;Harald Hübner;Nuska Tschammer;Peter Gmeiner

  • Covalent agonists for studying G protein-coupled receptor activation

    Dietmar Weichert;Andrew C. Kruse;Aashish Manglik;Christine Hiller

  • Structure-guided development of heterodimer-selective GPCR ligands

    Harald Hübner;Tamara Schellhorn;Marie Gienger;Carolin Schaab

  • Functionally selective dopamine D₂, D₃ receptor partial agonists

    Dorothee Möller;Ralf C Kling;Marika Skultety;Kristina Leuner

  • 1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands.

    Daniela Huber;Harald Hübner;Peter Gmeiner

  • Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

    Katharina Ehrlich;Angela Götz;Stefan Bollinger;Nuska Tschammer

  • Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level

    Alina Tabor;Siegfried Weisenburger;Ashutosh Banerjee;Nirupam Purkayastha

  • Bivalent dopamine D2 receptor ligands: synthesis and binding properties.

    Julia Kühhorn;Harald Hübner;Peter Gmeiner

  • Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles.

    Karin Schlotter;Frank Boeckler;Harald Hübner;Peter Gmeiner

  • Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

    Hongtao Liu;Josefa Hofmann;Inbar Fish;Benjamin Schaake

  • 2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.

    Cécile Enguehard-Gueiffier;Harald Hübner;Ahmed El Hakmaoui;Hassan Allouchi

  • Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.

    Nuska Tschammer;Jan Elsner;Angela Goetz;Katharina Ehrlich

  • Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy

    Jun Xu;Yunfei Hu;Jonas Kaindl;Philipp Risel

  • Parallel synthesis and biological screening of dopamine receptor ligands taking advantage of a click chemistry based BAL linker.

    Laura Bettinetti;Stefan Löber;Harald Hübner;Peter Gmeiner

  • Functionally Selective Dopamine D2/D3 Receptor Agonists Comprising an Enyne Moiety

    Christine Hiller;Ralf C. Kling;Frank W. Heinemann;Karsten Meyer

Frequent Co-Authors

Peter Gmeiner
Peter Gmeiner University of Erlangen-Nuremberg
Brian K. Kobilka
Brian K. Kobilka Stanford University
Antonio Argiolas
Antonio Argiolas University of Cagliari
Monika Pischetsrieder
Monika Pischetsrieder University of Erlangen-Nuremberg
Maria Rosaria Melis
Maria Rosaria Melis University of Cagliari
Armin Buschauer
Armin Buschauer University of Regensburg
Johannes Kornhuber
Johannes Kornhuber University of Göttingen
Roger K. Sunahara
Roger K. Sunahara University of California, San Diego
Brian K. Shoichet
Brian K. Shoichet University of California, San Francisco
Christian Alzheimer
Christian Alzheimer University of Erlangen-Nuremberg

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