World's Best Scientists 2026 revealed!
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Lei Shi

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
18073
World Ranking
8562
National Ranking
3847

Lei Shi publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Lei Shi sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 205 publications — 52nd percentile

52% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Lei Shi D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Lei Shi sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 66 D-Index — 57th percentile

57% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Lei Shi is affiliated with the National Institute on Drug Abuse in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and neuroscience. Their body of work spans molecular biology, cellular and molecular neuroscience, computational theory and mathematics, pharmacology, and cell biology.

The scientist's research primarily focuses on receptor mechanisms and signaling, as well as neuropeptides and animal physiology. Other major topics include neurotransmitter receptor influence on behavior, pharmacological receptor mechanisms and effects, neuroscience and neuropharmacology research, computational drug discovery methods, and monoclonal and polyclonal antibodies research.

Shi's recent publications include the following papers:

  • GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision, 2022, Cell
  • The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter, 2020, Nature Communications
  • A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity, 2020, Science Signaling
  • Methods of study on conformation of polysaccharides from natural products: A review, 2024, International Journal of Biological Macromolecules
  • Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism, 2020, eLife

Shi frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Pharmacology and Experimental Therapeutics, ACS Chemical Neuroscience, Journal of Medicinal Chemistry, and Journal of Chemical Information and Modeling.

The scientist has collaborated often with several researchers, including Kuo Hao Lee, David R. Sibley, R. Benjamin Free, Amy Hauck Newman, and Bing Xie.

Best Publications

  • Structure of the human dopamine d3 receptor in complex with a d2/d3 selective antagonist.

    Ellen Y. T. Chien;Wei Liu;Qiang Zhao;Vsevolod Katritch

  • Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6

    Juan A. Ballesteros;Anne D. Jensen;George Liapakis;George Liapakis;Søren G.F. Rasmussen

  • Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

    Lei Shi;Benjamin P Tu

  • Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors.

    Juan A. Ballesteros;Lei Shi;Jonathan A. Javitch

  • β2 Adrenergic Receptor Activation MODULATION OF THE PROLINE KINK IN TRANSMEMBRANE 6 BY A ROTAMER TOGGLE SWITCH

    Lei Shi;George Liapakis;Rui Xu;Frank Guarnieri

  • Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.

    Christine Saunders;Jasmine V. Ferrer;Lei Shi;Jiayun Chen

  • The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.

    Lei Shi;Matthias Quick;Yongfang Zhao;Harel Weinstein

  • The binding sites for cocaine and dopamine in the dopamine transporter overlap

    Thijs Beuming;Julie Kniazeff;Marianne L Bergmann;Lei Shi

  • The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop.

    Lei Shi;Jonathan A Javitch

  • Mannose-binding Lectin-deficient Mice Are Susceptible to Infection with Staphylococcus aureus

    Lei Shi;Kazue Takahashi;Joseph Dundee;Sarit Shahroor-Karni

  • Dopamine D2 receptors form higher order oligomers at physiological expression levels

    Wen Guo;Eneko Urizar;Michaela Kralikova;Juan Carlos Mobarec

  • A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function.

    Thijs Beuming;Lei Shi;Jonathan A. Javitch;Harel Weinstein

  • SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures.

    Gang Hao;Behrad Derakhshan;Lei Shi;Fabien Campagne

  • The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer.

    Wen Guo;Lei Shi;Jonathan A. Javitch

  • Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation

    Wen Guo;Lei Shi;Marta Filizola;Harel Weinstein

  • Mannose-Binding Lectin Is a Regulator of Inflammation That Accompanies Myocardial Ischemia and Reperfusion Injury

    Mary C. Walsh;Todd Bourcier;Kazue Takahashi;Lei Shi

  • Mannose-Binding Lectin-Deficient Mice Display Defective Apoptotic Cell Clearance but No Autoimmune Phenotype

    Lynda M. Stuart;Lynda M. Stuart;Kazue Takahashi;Lei Shi;John Savill

  • Substrate-modulated gating dynamics in a Na + -coupled neurotransmitter transporter homologue

    Yongfang Zhao;Daniel S. Terry;Lei Shi;Matthias Quick

  • TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion–Positive Intrahepatic Cholangiocarcinoma

    Lipika Goyal;Lei Shi;Leah Y Liu;Ferran Fece de la Cruz

  • P085. SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures

    Steven S. Gross;Gang Hao;Behrad Derakhshan;M. Carrie Garceau

Frequent Co-Authors

Jonathan A. Javitch
Jonathan A. Javitch Columbia University
Harel Weinstein
Harel Weinstein Cornell University
Amy Hauck Newman
Amy Hauck Newman National Institutes of Health
Ulrik Gether
Ulrik Gether University of Copenhagen
Kazue Takahashi
Kazue Takahashi Harvard University
Benjamin P. Tu
Benjamin P. Tu The University of Texas Southwestern Medical Center
Hassane S. Mchaourab
Hassane S. Mchaourab Vanderbilt University
R. Alan B. Ezekowitz
R. Alan B. Ezekowitz Harvard University
Carl Nathan
Carl Nathan Cornell University
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium

External Links

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Best Scientists Citing Lei Shi

Jonathan A. Javitch

Jonathan A. Javitch

Columbia University

Publications: 82

Harel Weinstein

Harel Weinstein

Cornell University

Publications: 62

Kazue Takahashi

Kazue Takahashi

Harvard University

Publications: 51

Harald H. Sitte

Harald H. Sitte

Medical University of Vienna

Publications: 51

Amy Hauck Newman

Amy Hauck Newman

National Institutes of Health

Publications: 49

Kjell Fuxe

Kjell Fuxe

Karolinska Institute

Publications: 44

Raymond C. Stevens

Raymond C. Stevens

University of Southern California

Publications: 43

Brian K. Kobilka

Brian K. Kobilka

Stanford University

Publications: 43

Steffen Thiel

Steffen Thiel

Aarhus University

Publications: 42

Graeme Milligan

Graeme Milligan

University of Glasgow

Publications: 40

Gregory L. Stahl

Gregory L. Stahl

Brigham and Women's Hospital

Publications: 39

Rafael Franco

Rafael Franco

University of Barcelona

Publications: 38

Jean-Philippe Pin

Jean-Philippe Pin

University of Montpellier

Publications: 37

Bryan L. Roth

Bryan L. Roth

University of North Carolina at Chapel Hill

Publications: 35

Ulrik Gether

Ulrik Gether

University of Copenhagen

Publications: 35

Leonardo Pardo

Leonardo Pardo

Autonomous University of Barcelona

Publications: 35

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