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Hassane S. Mchaourab

Hassane S. Mchaourab

D-Index & Metrics

Chemistry

D-Index
65
Citations
14164
World Ranking
7719
National Ranking
2257

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Hassane S. Mchaourab is affiliated with Vanderbilt University in the United States and has a research focus primarily within the field of Biochemistry, Genetics and Molecular Biology. Their work encompasses various subfields, including Molecular Biology, Biophysics, Oncology, Spectroscopy, and Materials Chemistry.

The primary research topics addressed by Mchaourab include:

  • Electron Spin Resonance Studies
  • Protein Structure and Dynamics
  • Drug Transport and Resistance Mechanisms
  • Caveolin-1 and cellular processes
  • RNA and protein synthesis mechanisms
  • Advanced NMR Techniques and Applications
  • DNA and Nucleic Acid Chemistry

Mchaourab has contributed to numerous scientific publications, several of which have garnered significant citations. Recent selected papers include:

  • "Sampling alternative conformational states of transporters and receptors with AlphaFold2," 2022, published in eLife
  • "Benchmark Test and Guidelines for DEER/PELDOR Experiments on Nitroxide-Labeled Biomolecules," 2021, published in Journal of the American Chemical Society
  • "SPEACH_AF: Sampling protein ensembles and conformational heterogeneity with Alphafold2," 2022, published in PLoS Computational Biology
  • "Modeling conformational states of proteins with AlphaFold," 2023, published in Current Opinion in Structural Biology
  • "Molecular architecture of the human caveolin-1 complex," 2022, published in Science Advances

Their frequent coauthors include Erkan Karakaş, Richard A. Stein, Derek P. Claxton, Jens Meiler, and Irina Novikova, reflecting collaborative efforts across various facets of their research interests.

Mchaourab's work is published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information), Biophysical Journal, Journal of Biological Chemistry, and Nature Communications.

In 2012, Mchaourab was recognized as a Fellow of the American Association for the Advancement of Science (AAAS), an acknowledgment within the scientific community. This distinction is part of their professional achievements and contributions to advancing scientific knowledge.

Best Publications

  • Motion of spin-labeled side chains in T4 lysozyme. Correlation with protein structure and dynamics.

    Hassane S. Mchaourab;Michael A. Lietzow;Kalman Hideg;Wayne L. Hubbell

  • Watching proteins move using site-directed spin labeling

    Wayne L Hubbell;Hassane S Mchaourab;Christian Altenbach;Michael A Lietzow

  • Molecular architecture of human prion protein amyloid: A parallel, in-register β-structure

    Nathan J. Cobb;Frank D. Sönnichsen;Hassane Mchaourab;Witold K. Surewicz

  • Protein structure determination using long-distance constraints from double-quantum coherence ESR: study of T4 lysozyme.

    Petr P. Borbat;Hassane S. Mchaourab;Jack H. Freed

  • Subunit Exchange of Small Heat Shock Proteins ANALYSIS OF OLIGOMER FORMATION OF αA-CRYSTALLIN AND Hsp27 BY FLUORESCENCE RESONANCE ENERGY TRANSFER AND SITE-DIRECTED TRUNCATIONS

    Michael P. Bova;Hassane S. Mchaourab;Yun Han;Bernard K.-K. Fung

  • SPEACH_AF: Sampling protein ensembles and conformational heterogeneity with Alphafold2

    Unknown

  • Structure and mechanism of protein stability sensors: chaperone activity of small heat shock proteins.

    Hassane S. Mchaourab;Jared A. Godar;Phoebe L. Stewart

  • Conformation of T4 lysozyme in solution. Hinge-bending motion and the substrate-induced conformational transition studied by site-directed spin labeling

    Hassane S. Mchaourab;Kyoung Joon Oh;Celia J. Fang;Wayne L. Hubbell

  • Mechanism of NMDA Receptor Channel Block by MK-801 and Memantine

    Xianqiang Song;Morten Ø. Jensen;Vishwanath Jogini;Richard A. Stein

  • Toward the Fourth Dimension of Membrane Protein Structure: Insight into Dynamics from Spin-Labeling EPR Spectroscopy

    Hassane S. Mchaourab;P. Ryan Steed;Kelli Kazmier

  • Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

    Brandy Verhalen;Reza Dastvan;Sundarapandian Thangapandian;Yelena Peskova

  • Small heat-shock protein structures reveal a continuum from symmetric to variable assemblies.

    Dana A. Haley;Michael P. Bova;Qing Ling Huang;Hassane S. Mchaourab

  • Benchmark test and guidelines for DEER/PELDOR experiments on nitroxide-labeled biomolecules

    Olav Schiemann;Caspar A Heubach;Dinar Abdullin;Katrin Ackermann

  • Mechanism of NMDA Receptor Inhibition and Activation.

    Shujia Zhu;Richard A. Stein;Craig Yoshioka;Chia Hsueh Lee

  • De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

    Hamilton Pj;Campbell Ng;Sharma S;Erreger K

  • Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.

    Katharina L. Dürr;Lei Chen;Richard A. Stein;Rita De Zorzi;Rita De Zorzi

  • Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters

    Derek P Claxton;Matthias Quick;Lei Shi;Fernanda Delmondes de Carvalho

  • Structural Basis of Energy Transduction in the Transport Cycle of MsbA

    Jinhui Dong;Guangyong Yang;Hassane S. Mchaourab

  • Mechanism of Chaperone Function in Small Heat Shock Proteins DISSOCIATION OF THE HSP27 OLIGOMER IS REQUIRED FOR RECOGNITION AND BINDING OF DESTABILIZED T4 LYSOZYME

    R. Shashidharamurthy;Hanane A. Koteiche;Jinhui Dong;Hassane S. Mchaourab

  • Conformational cycle of the ABC transporter MsbA in liposomes: detailed analysis using double electron-electron resonance spectroscopy.

    Ping Zou;Marco Bortolus;Hassane S. Mchaourab

  • Conformational motion of the ABC transporter MsbA induced by ATP hydrolysis.

    Peter P Borbat;Kavitha Surendhran;Marco Bortolus;Ping Zou

Frequent Co-Authors

Jens Meiler
Jens Meiler Vanderbilt University
Emad Tajkhorshid
Emad Tajkhorshid University of Illinois at Urbana-Champaign
Phoebe L. Stewart
Phoebe L. Stewart Case Western Reserve University
James S. Hyde
James S. Hyde Medical College of Wisconsin
Lei Shi
Lei Shi National Institute on Drug Abuse
Benoît Roux
Benoît Roux University of Chicago
Aurelio Galli
Aurelio Galli University of Alabama at Birmingham
Wayne L. Hubbell
Wayne L. Hubbell University of California, Los Angeles
Eric Gouaux
Eric Gouaux Oregon Health & Science University
Kevin L. Schey
Kevin L. Schey Vanderbilt University

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