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Chemistry

D-Index
102
Citations
34918
World Ranking
1173
National Ranking
462

Physics

D-Index
101
Citations
32845
World Ranking
1614
National Ranking
854

Research.com Recognitions

  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2008 - E. Bright Wilson Award in Spectroscopy, American Chemical Society (ACS)
  • 1997 - Irving Langmuir Award, American Chemical Society (ACS)
  • 1994 - Fellow of the American Academy of Arts and Sciences
  • 1984 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1976 - Fellow of American Physical Society (APS)
  • 1966 - Fellow of Alfred P. Sloan Foundation

Overview

Jack H. Freed is affiliated with Cornell University in the United States. Their research spans key areas of biochemistry, genetics, and molecular biology with a focus on several intersecting subfields.

The primary fields of study encompass biochemistry, genetics, and molecular biology, supported by significant contributions in materials chemistry, molecular biology, biophysics, spectroscopy, and infectious diseases.

Freed's main research topics include electron spin resonance studies, advanced NMR techniques and applications, crystallization and solubility studies, X-ray diffraction in crystallography, lipid membrane structure and behavior, SARS-CoV-2 and COVID-19 research, and spectroscopy and quantum chemical studies.

Their frequent publication venues reflect multidisciplinary work, with numerous articles in bioRxiv (Cold Spring Harbor Laboratory), The Cambridge Structural Database, Biophysical Journal, Journal of the American Chemical Society, and The Journal of Physical Chemistry B.

Freed has collaborated extensively with several researchers across multiple papers. Frequent co-authors include Alex L. Lai, Madhur Srivastava, Kyle M. Lancaster, Valiallah Hosseininasab, and Ida M. DiMucci.

Notable recent papers authored or co-authored by Freed are:

  • Benchmark Test and Guidelines for DEER/PELDOR Experiments on Nitroxide-Labeled Biomolecules (2021, Journal of the American Chemical Society)
  • Ca 2+ Ions Promote Fusion of Middle East Respiratory Syndrome Coronavirus with Host Cells and Increase Infectivity (2020, Journal of Virology)
  • SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca2+ (2021, Journal of Molecular Biology)
  • Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation (2023, Nature Communications)
  • Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering (2021, mBio)

Throughout their career, Freed has been recognized by several professional societies and organizations. Awards and honors include:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2009
  • E. Bright Wilson Award in Spectroscopy, American Chemical Society (ACS), 2008
  • Irving Langmuir Award, American Chemical Society (ACS), 1997
  • Fellow of the American Academy of Arts and Sciences, 1994
  • Fellow of the John Simon Guggenheim Memorial Foundation, 1984
  • Fellow of the American Physical Society (APS), 1976
  • Fellow of the Alfred P. Sloan Foundation, 1966

Best Publications

  • Nonlinear-least-squares analysis of slow-motion EPR spectra in one and two dimensions using a modified levenberg-marquardt algorithm

    David E. Budil;Sanghyuk Lee;Sunil Saxena;Jack H. Freed

  • Theory of Linewidths in Electron Spin Resonance Spectra

    Jack H. Freed;George K. Fraenkel

  • Dynamic effects of pair correlation functions on spin relaxation by translational diffusion in liquids

    Lian‐Pin Hwang;Jack H. Freed

  • Dynamic effects of pair correlation functions on spin relaxation by translational diffusion in liquids. II. Finite jumps and independent T1 processes

    Jack H. Freed

  • Electron spin resonance line shapes and saturation in the slow motional region

    Jack H. Freed;Gerald V. Bruno;Carl F. Polnaszek

  • 3 – Theory of Slow Tumbling ESR Spectra for Nitroxides

    Jack H. Freed

  • Stochastic‐molecular theory of spin–relaxation for liquid crystals

    Jack H. Freed

  • The determination of pair distance distributions by pulsed ESR using Tikhonov regularization.

    Yun-Wei Chiang;Peter P. Borbat;Jack H. Freed

  • Electron spin resonance in studies of membranes and proteins.

    P. P. Borbat;A. J. Costa-Filho;K. A. Earle;J. K. Moscicki

  • An ESR Study of Anisotropic Rotational Reorientation and Slow Tumbling in Liquid and Frozen Media

    S. A. Goldman;G. V. Bruno;C. F. Polnaszek;J. H. Freed

  • Calculating Slow Motional Magnetic Resonance Spectra

    David J. Schneider;Jack H. Freed

  • Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages.

    Yankun Li;Mingtao Ge;Laura Ciani;George Kuriakose

  • Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles

    Elka R. Georgieva;Trudy F. Ramlall;Peter P. Borbat;Jack H. Freed

  • Calculation of ESR spectra and related Fokker–Planck forms by the use of the Lanczos algorithm

    Giorgio Moro;Jack H. Freed

  • Protein structure determination using long-distance constraints from double-quantum coherence ESR: study of T4 lysozyme.

    Petr P. Borbat;Hassane S. Mchaourab;Jack H. Freed

  • Multiple-quantum ESR and distance measurements

    Petr P. Borbat;Jack H. Freed

  • Electron spin resonance studies of anisotropic ordering, spin relaxation, and slow tumbling in liquid crystalline solvents. 3. Smectics

    K. V. S. Rao;Carl F. Polnaszek;Jack H. Freed

  • Estimating slow-motional rotational correlation times for nitroxides by electron spin resonance

    S. A. Goldman;G. V. Bruno;J. H. Freed

  • Electron spin resonance studies of anisotropic rotational reorientation and slow tumbling in liquid and frozen media. III. Perdeuterated 2,2,6,6-tetramethyl-4-piperidone N-oxide and an analysis of fluctuating torques

    James S. Hwang;Ronald P. Mason;Lian Pin Hwang;Jack H. Freed

  • Reconstruction of the Chemotaxis Receptor-Kinase Assembly

    Sang-Youn Park;Peter P Borbat;Gabriela Gonzalez-Bonet;Jaya Bhatnagar

Frequent Co-Authors

Brian R. Crane
Brian R. Crane Cornell University
Hening Lin
Hening Lin Howard Hughes Medical Institute
Gary R. Whittaker
Gary R. Whittaker Cornell University
David Eliezer
David Eliezer Cornell University
Wayne L. Hubbell
Wayne L. Hubbell University of California, Los Angeles
Benoît Roux
Benoît Roux University of Chicago
Ronald P. Mason
Ronald P. Mason National Institutes of Health
Scott C. Blanchard
Scott C. Blanchard St. Jude Children's Research Hospital
Barbara Baird
Barbara Baird Cornell University
Christopher K. Ober
Christopher K. Ober Cornell University

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