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Peter J. Scammells

Peter J. Scammells

D-Index & Metrics

Chemistry

D-Index
57
Citations
11519
World Ranking
11092
National Ranking
260

Overview

Peter J. Scammells is affiliated with Monash University in Australia and has a research profile primarily rooted in biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their work spans multiple subfields including molecular biology, cellular and molecular neuroscience, public health, environmental and occupational health, oncology, and organic chemistry.

Their research topics cover a range of areas, notably:

  • Receptor Mechanisms and Signaling
  • Pharmacological Receptor Mechanisms and Effects
  • Malaria Research and Control
  • Neuropeptides and Animal Physiology
  • Peptidase Inhibition and Analysis
  • Computational Drug Discovery Methods
  • Adenosine and Purinergic Signaling

Frequent publication venues for the scientist include:

  • Journal of Medicinal Chemistry
  • eLife
  • European Journal of Medicinal Chemistry
  • ChemMedChem
  • bioRxiv (Cold Spring Harbor Laboratory)

Notable recent papers include:

  • "Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia," 2021, Nature
  • "Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway," 2022, eLife
  • "Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX)," 2020, Journal of Medicinal Chemistry
  • "API ionic liquids: probing the effect of counterion structure on physical form and lipid solubility," 2020, RSC Advances
  • "Driving antimalarial design through understanding of target mechanism," 2020, Biochemical Society Transactions

Frequent co-authors in their collaborative work are:

  • Arthur Christopoulos
  • Ben Capuano
  • Céline Valant
  • Sheena McGowan
  • Manuela Jörg

Best Publications

  • Biodegradable ionic liquids : Part II. Effect of the anion and toxicology

    M Teresa Garcia;Nicholas Gathergood;Peter John Scammells

  • Biodegradable ionic liquids: Part I. Concept, preliminary targets and evaluation

    Nicholas Gathergood;Nicholas Gathergood;M Teresa Garcia;Peter John Scammells

  • Biodegradable ionic liquids : Part III. The first readily biodegradable ionic liquids

    Nicholas Gathergood;Peter John Scammells;M Teresa Garcia

  • Ionic Liquids: The Neglected Issues

    Peter John Scammells;Janet L Scott;Robert D Singer

  • The role of kinetic context in apparent biased agonism at GPCRs

    Carmen Klein Herenbrink;David A. Sykes;Prashant Donthamsetti;Meritxell Canals

  • Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

    Alisa Glukhova;David M. Thal;Anh T. Nguyen;Elizabeth A. Vecchio

  • Biodegradable pyridinium ionic liquids: design, synthesis and evaluation

    Jitendra Rameshlal Harjani;Robert D Singer;M Teresa Garcia;Peter John Scammells

  • Design and Preparation of Room-Temperature Ionic Liquids Containing Biodegradable Side Chains

    Nicholas Gathergood;Peter J. Scammells

  • A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC/ALLOSTERIC LIGAND

    Celine Valant;Karen Joan Gregory;Nathan Eric Hall;Peter John Scammells

  • Phosphonium ionic liquids: design, synthesis and evaluation of biodegradability

    Farzad Atefi;M Teresa Garcia;Robert D Singer;Peter John Scammells

  • Transformation of Poorly Water-Soluble Drugs into Lipophilic Ionic Liquids Enhances Oral Drug Exposure from Lipid Based Formulations

    Yasemin Sahbaz;Hywel David Williams;Tri-Hung Nguyen;Jessica Anne Saunders

  • Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

    Christopher J. Draper-Joyce;Christopher J. Draper-Joyce;Rebecca Bhola;Jinan Wang;Apurba Bhattarai

  • Further investigation of the biodegradability of imidazolium ionic liquids

    Jitendra Rameshlal Harjani;Jeff Farrell;M Teresa Garcia;Robert D Singer

  • 2-Amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors

    Joel M. Linden;Ray A. Ollson;Peter J. Scammells

  • Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

    Hywel David Williams;Yasemin Sahbaz;Leigh Ford;Tri-Hung Nguyen

  • 2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding: new 3, 4-, and 5-modifications.

    Henning Lütjens;Andrea Zickgraf;Heidi Figler;Joel Linden

  • Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

    Luigi Aurelio;Celine Valant;Celine Valant;Bernard Luke Flynn;Patrick M Sexton;Patrick M Sexton

  • Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist

    Celine Valant;Lauren Therese May;Luigi Aurelio;Chung Hui Chuo

  • A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation

    Meritxell Canals;J. Robert Lane;Adriel Wen;Peter J. Scammells

  • 2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers.

    George Nikolakopoulos;Heidi Figler;Joel Linden;Peter John Scammells

Frequent Co-Authors

Arthur Christopoulos
Arthur Christopoulos Monash University
Patrick M. Sexton
Patrick M. Sexton Monash University
Colin W. Pouton
Colin W. Pouton Monash University
Ronald J. Quinn
Ronald J. Quinn Griffith University
Joel Linden
Joel Linden University of Virginia
Raymond S. Norton
Raymond S. Norton Monash University
Christopher J.H. Porter
Christopher J.H. Porter Monash University
Steven E. Bottle
Steven E. Bottle Queensland University of Technology
Jonathan M. White
Jonathan M. White University of Melbourne
Edward R. T. Tiekink
Edward R. T. Tiekink Sunway University

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