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Molecular Biology

D-Index
63
Citations
18696
World Ranking
1786
National Ranking
32

Overview

Patrick Matthias is affiliated with the Friedrich Miescher Institute in Switzerland. Their research work spans biochemistry, genetics, molecular biology, immunology, and microbiology, with a primary focus on molecular biology and immunology.

The scientist's research topics cover several key areas including histone deacetylase inhibitors research, peptidase inhibition and analysis, ubiquitin and proteasome pathways, protein degradation and inhibitors, signaling pathways in disease, interferon and immune responses, and HIV research and treatment.

Frequent coauthors in their publications include Longlong Wang, Yohei Yamauchi, Jacint Sanchez, Georg Kempf, and Chun Cao.

Patrick Matthias has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Biological Chemistry, Nature Communications, Cell Reports, and Methods in Molecular Biology.

Selected recent papers illustrate the scope of their research:

  • The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation, 2020, Journal of Biological Chemistry
  • EEF1A1 deacetylation enables transcriptional activation of remyelination, 2020, Nature Communications
  • Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways, 2022, Cell Reports
  • How Influenza Virus Uses Host Cell Pathways during Uncoating, 2021, Cells
  • OBF1 and Oct factors control the germinal center transcriptional program, 2021, Blood

Best Publications

  • Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

    Edgar Schreiber;Patrick Matthias;Michael M. Müller;Walter Schaffner

  • HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

    Yu Zhang;Na Li;Cécile Caron;Gabriele Matthias

  • Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

    Yu Zhang;So Hee Kwon;Teppei Yamaguchi;Fabien Cubizolles

  • A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells.

    Michael M. Müller;Siegfried Ruppert;Walter Schaffner;Patrick Matthias

  • OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins

    Michel Strubin;John W Newell;Patrick Matthias

  • The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response

    SoHee Kwon;Yu Zhang;Yu Zhang;Patrick Matthias

  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.

    Cyril Boyault;Yu Zhang;Sabrina Fritah;Cécile Caron

  • High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage.

    Valérie Geoffroy;Michaela Kneissel;Brigitte Fournier;Alan Boyde

  • Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression

    Teppei Yamaguchi;Fabien Cubizolles;Yu Zhang;Nina Reichert

  • HDAC6–p97/VCP controlled polyubiquitin chain turnover

    Cyril Boyault;Benoit Gilquin;Yu Zhang;Vladimir Rybin

  • B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation

    Daniel B. Schubart;Antonius Rolink;Marie H. Kosco-Vilbois;Florence Botteri

  • Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA)

    E. Schreiber;P. Matthias;M. M. Müller;W. Schaffner

  • Transcriptional networks in developing and mature B cells.

    Patrick Matthias;Antonius G. Rolink

  • Structural Insights Into Hdac6 Tubulin Deacetylation and its Selective Inhibition

    Yasuyuki Miyake;Jeremy J Keusch;Longlong Wang;Makoto Saito

  • Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells.

    Edwin F. de Zoeten;Liqing Wang;Kyle Butler;Ulf H. Beier

  • Acetylation site specificities of lysine deacetylase inhibitors in human cells.

    Christian Schölz;Brian T Weinert;Sebastian A Wagner;Petra Beli

  • Influenza A virus uses the aggresome processing machinery for host cell entry.

    Indranil Banerjee;Yasuyuki Miyake;Samuel Philip Nobs;Christoph Schneider

  • Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer.

    T. Gerster;P. Matthias;M. Thali;J. Jiricny

  • Acetylation of intrinsically disordered regions regulates phase separation.

    Makoto Saito;Makoto Saito;Daniel Hess;Jan Eglinger;Anatol W Fritsch

  • Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

    Maria A. Halili;Melanie R. Andrews;Larisa I. Labzin;Kate Schroder

Frequent Co-Authors

Christian Seiser
Christian Seiser Medical University of Vienna
Walter Schaffner
Walter Schaffner University of Zurich
Yu Zhang
Yu Zhang Peking University
Saadi Khochbin
Saadi Khochbin Grenoble Alpes University
Wilfried Ellmeier
Wilfried Ellmeier Medical University of Vienna
Lynn M. Corcoran
Lynn M. Corcoran Walter and Eliza Hall Institute of Medical Research
Daniel Hess
Daniel Hess Friedrich Miescher Institute
Günter Steiner
Günter Steiner Medical University of Vienna
Antonius Rolink
Antonius Rolink University of Basel
Ueli Suter
Ueli Suter École Polytechnique Fédérale de Lausanne

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