World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
66
Citations
17427
World Ranking
2989
National Ranking
1387

Biology and Biochemistry

D-Index
66
Citations
17501
World Ranking
8582
National Ranking
3857

Research.com Recognitions

  • 1991 - Fellow of Alfred P. Sloan Foundation

Overview

Brian Popko is affiliated with Northwestern University in the United States. Their research primarily focuses on various aspects of neuroscience, particularly mechanisms related to neurogenesis, neuroplasticity, and neuroinflammation.

The main fields of study in Brian Popko's work include:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, they have contributed to several subfields such as:

  • Molecular Biology
  • Neurology
  • Developmental Neuroscience
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience

Brian Popko's research spans multiple topics, notably:

  • Neurogenesis and neuroplasticity mechanisms
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Multiple Sclerosis Research Studies
  • Peripheral Neuropathies and Disorders
  • RNA regulation and disease
  • MicroRNA in disease regulation
  • RNA Research and Splicing

Their recent publications demonstrate a focus on central nervous system responses, remyelination, and metabolism, including:

  • "CNS fibroblasts form a fibrotic scar in response to immune cell infiltration" (2021) in Nature Neuroscience
  • "Pre-clinical and Clinical Implications of "Inside-Out" vs. "Outside-In" Paradigms in Multiple Sclerosis Etiopathogenesis" (2020) in Frontiers in Cellular Neuroscience
  • "Oligodendroglial fatty acid metabolism as a central nervous system energy reserve" (2024) in Nature Neuroscience
  • "Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques" (2020) in Journal of Cerebral Blood Flow & Metabolism
  • "Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment" (2021) in eLife

They frequently collaborate with other researchers in their field. Their most common co-authors are:

  • Yanan Chen
  • Benayahu Elbaz
  • Stephen D. Miller
  • Roumen Balabanov
  • Joseph R. Podojil

Brian Popko has published extensively in venues such as:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Glia
  • Nature Neuroscience

In recognition of their contributions, Brian Popko was named a Fellow of the Alfred P. Sloan Foundation in 1991.

Best Publications

  • An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

    Heather P. Harding;Yuhong Zhang;Huiquing Zeng;Isabel Novoa

  • Myelination in the Absence of Galactocerebroside and Sulfatide: Normal Structure with Abnormal Function and Regional Instability

    Timothy Coetzee;Nobuya Fujita;Jeffrey Dupree;Riyi Shi

  • Expression of a myelin basic protein gene in transgenic shiverer mice: Correction of the dysmyelinating phenotype

    Carol Readhead;Carol Readhead;Brian Popko;Brian Popko;Naoki Takahashi;Naoki Takahashi;H. David Shine

  • Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease.

    Sebastian Werneburg;Jonathan Jung;Rejani B. Kunjamma;Seung Kwon Ha

  • Paranodal junction formation and spermatogenesis require sulfoglycolipids.

    Koichi Honke;Yukie Hirahara;Jeffrey Dupree;Kinuko Suzuki

  • Inducible site-specific recombination in myelinating cells.

    Nathalie H. Doerflinger;Wendy B. Macklin;Brian Popko

  • Axo-Glial Interactions Regulate the Localization of Axonal Paranodal Proteins

    Jeffrey L. Dupree;Jean-Antoine Girault;Brian Popko

  • Endoplasmic reticulum stress in disorders of myelinating cells.

    Wensheng Lin;Brian Popko

  • Molecular Control of Oligodendrocyte Development

    Benayahu Elbaz;Brian Popko

  • Myelin galactolipids are essential for proper node of Ranvier formation in the CNS

    Jeffrey L. Dupree;Timothy Coetzee;Andrew Blight;Kinuko Suzuki

  • A Myelin Galactolipid, Sulfatide, Is Essential for Maintenance of Ion Channels on Myelinated Axon But Not Essential for Initial Cluster Formation

    Tomoko Ishibashi;Jeffrey L. Dupree;Kazuhiro Ikenaka;Yukie Hirahara

  • Interferon-γ inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

    Wensheng Lin;April Kemper;Jeffrey L. Dupree;Heather P. Harding

  • Myelin deficient mice: Expression of myelin basic protein and generation of mice with varying levels of myelin

    Brian Popko;Brian Popko;Carmie Puckett;Carmie Puckett;Eric Lai;Eric Lai;H.David Shine

  • Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.

    Pu Ting Xu;Donald Schmechel;Donald Schmechel;Tracie Rothrock-Christian;D. Scott Burkhart

  • Targeted Disruption of the Mouse Sphingolipid Activator Protein Gene: A Complex Phenotype, Including Severe Leukodystrophy and Wide-Spread Storage of Multiple Sphingolipids

    Nobuya Fujita;Kinuko Suzuki;Marie T. Vanier;Brian Popko

  • Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-γ

    Wensheng Lin;Heather P. Harding;David Ron;Brian Popko

  • The effects of interferon-gamma on the central nervous system.

    Brian Popko;Joshua G. Corbin;Kristine D. Baerwald;Jeffrey Dupree

  • Targeted CNS Expression of Interferon-γ in Transgenic Mice Leads to Hypomyelination, Reactive Gliosis, and Abnormal Cerebellar Development

    Joshua G. Corbin;Donna Kelly;Erick M. Rath;Kristine D. Baerwald

  • The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage

    Wensheng Lin;Samantha L. Bailey;Hanson Ho;Heather P. Harding

  • Oligodendrocyte death results in immune-mediated CNS demyelination

    Maria Traka;Joseph R Podojil;Derrick P McCarthy;Stephen D Miller

Frequent Co-Authors

Kinuko Suzuki
Kinuko Suzuki University of North Carolina at Chapel Hill
Jeffrey L. Dupree
Jeffrey L. Dupree Virginia Commonwealth University
Kunihiko Suzuki
Kunihiko Suzuki University of North Carolina at Chapel Hill
Nobuyo Maeda
Nobuyo Maeda University of North Carolina at Chapel Hill
Leroy Hood
Leroy Hood University of Washington
Raymond P. Roos
Raymond P. Roos University of Chicago
Heather P. Harding
Heather P. Harding University of Cambridge
David Ron
David Ron University of Cambridge
Stephen D. Miller
Stephen D. Miller Northwestern University
Daniel S. Reich
Daniel S. Reich National Institutes of Health

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