World's Best Scientists 2026 revealed!
Konrad Sandhoff

Konrad Sandhoff

Award Badge
Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
116
Citations
43708
World Ranking
761
National Ranking
53

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award
  • 1999 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Human Genetics and Molecular Medicine
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Konrad Sandhoff is affiliated with the University of Bonn in Germany. Their work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant focus on subfields including Physiology, Molecular Biology, Cell Biology, Clinical Biochemistry, and Neurology.

The scientist's research centers largely on topics such as Lysosomal Storage Disorders Research, Sphingolipid Metabolism and Signaling, Glycosylation and Glycoproteins Research, Cellular Transport and Secretion, Lipid Membrane Structure and Behavior, Metabolism and Genetic Disorders, and Calcium Signaling and Nucleotide Metabolism.

Frequent coauthors in their publications include Bernadette Breiden, Michael Beck, Roger Sandhoff, Akemi Tanaka, and Kinji Ohno.

Common venues for their publications are:

  • PubMed
  • UNC Libraries
  • International Journal of Molecular Sciences
  • Advances in Neurobiology
  • Biological Chemistry

Some representative recent papers authored or coauthored by Konrad Sandhoff include:

  • "Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal Disease," 2020, International Journal of Molecular Sciences
  • "GM2-gangliosidosis B1 variant: analysis of beta-hexosaminidase alpha gene abnormalities in seven patients," 2020, PubMed
  • "Acid Sphingomyelinase, a Lysosomal and Secretory Phospholipase C, Is Key for Cellular Phospholipid Catabolism," 2021, International Journal of Molecular Sciences
  • "Molecular analysis of the acid sphingomyelinase deficiency in a family with an intermediate form of Niemann-Pick disease," 2020, PubMed
  • "Neuronal Ganglioside and Glycosphingolipid (GSL) Metabolism and Disease," 2022, Advances in Neurobiology

Konrad Sandhoff has been recognized by membership in scientific organizations such as the German National Academy of Sciences Leopoldina, awarded in 1999 for contributions in Human Genetics and Molecular Medicine. They are also a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Direct observation of the nanoscale dynamics of membrane lipids in a living cell

    Christian Eggeling;Christian Ringemann;Rebecca Medda;Günter Schwarzmann

  • CD95 signaling via ceramide-rich membrane rafts.

    Heike Grassme;Andreas Jekle;Andrea Riehle;Heinz Schwarz

  • Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

    Thomas Kirkegaard;Anke G Roth;Nikolaj H T Petersen;Ajay K Mahalka

  • Enhanced insulin sensitivity in mice lacking ganglioside GM3

    Tadashi Yamashita;Akira Hashiramoto;Martin Haluzik;Hiroki Mizukami

  • A vital role for glycosphingolipid synthesis during development and differentiation

    Tadashi Yamashita;Ryuichi Wada;Teiji Sasaki;Chuxia Deng

  • Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease.

    Kenichi Horinouchi;Shai Erlich;Daniel P. Perl;Klaus Ferlinz

  • PRINCIPLES OF LYSOSOMAL MEMBRANE DIGESTION: Stimulation of Sphingolipid Degradation by Sphingolipid Activator Proteins and Anionic Lysosomal Lipids

    Thomas Kolter;Konrad Sandhoff

  • Physiology and pathophysiology of sphingolipid metabolism and signaling.

    Andrea Huwiler;Thomas Kolter;Josef Pfeilschifter;Konrad Sandhoff

  • Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis

    Florian Winau;Stephan Weber;Subash Sad;Juana de Diego

  • Sphingolipids-Their Metabolic Pathways and the Pathobiochemistry of Neurodegenerative Diseases.

    Thomas Kolter;Konrad Sandhoff

  • Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

    Kazunori Sango;Shoji Yamanaka;Shoji Yamanaka;Alexander Hoffmann;Yasuharu Okuda

  • Sphingolipid metabolism diseases.

    Thomas Kolter;Konrad Sandhoff

  • Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.

    A H Merrill;G van Echten;E Wang;K Sandhoff

  • Deficient hexosaminidase activity in an exceptional case of Tay-Sachs disease with additional storage of kidney globoside in visceral organs.

    K. Sandhoff;U. Andreae;H. Jatzkewitz

  • Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver.

    E C Mandon;I Ehses;J Rother;G van Echten

  • Characterization of Ceramide Synthesis A DIHYDROCERAMIDE DESATURASE INTRODUCES THE 4,5-TRANS-DOUBLE BOND OF SPHINGOSINE AT THE LEVEL OF DIHYDROCERAMIDE

    Christoph Michel;Gerhild van Echten-Deckert;Jürgen Rother;Konrad Sandhoff

  • Combinatorial ganglioside biosynthesis.

    Thomas Kolter;Richard L. Proia;Konrad Sandhoff

  • Acidic Sphingomyelinase Mediates Entry of N. gonorrhoeae into Nonphagocytic Cells

    Heike Grassmé;Erich Gulbins;Birgit Brenner;Klaus Ferlinz

  • Ganglioside metabolism. Enzymology, Topology, and regulation.

    G van Echten;K Sandhoff

  • The epidermal barrier function is dependent on the serine protease CAP1/Prss8

    Céline Leyvraz;Roch-Philippe Charles;Isabelle Rubera;Marjorie Guitard

Frequent Co-Authors

Athanassios Giannis
Athanassios Giannis Leipzig University
Richard L. Proia
Richard L. Proia National Institutes of Health
Edward H. Schuchman
Edward H. Schuchman Icahn School of Medicine at Mount Sinai
Richard R. Schmidt
Richard R. Schmidt University of Konstanz
Kinuko Suzuki
Kinuko Suzuki University of North Carolina at Chapel Hill
Kunihiko Suzuki
Kunihiko Suzuki University of North Carolina at Chapel Hill
J. M. Tager
J. M. Tager University of Amsterdam
John A. Barranger
John A. Barranger University of Pittsburgh
Derek Marsh
Derek Marsh Max Planck Society
Jacqueline N. Crawley
Jacqueline N. Crawley University of California, Davis

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