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Molecular Biology

D-Index
43
Citations
11189
World Ranking
2954
National Ranking
229

Overview

Alfredo Castello is affiliated with the MRC-University of Glasgow Centre For Virus Research in the United Kingdom. Their research activity is primarily situated within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. More specifically, their work focuses on Molecular Biology, Infectious Diseases, Immunology, Plant Science, and Cardiology and Cardiovascular Medicine as subfields of study.

The scientist's main research topics include RNA Research and Splicing, RNA modifications and cancer, RNA regulation and disease, RNA and protein synthesis mechanisms, interferon and immune responses, Viral Infections and Vectors, and Viral gastroenteritis research and epidemiology.

Recent publications by Alfredo Castello include:

  • A prenylated dsRNA sensor protects against severe COVID-19 (2021, Science)
  • Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection (2021, Molecular Cell)
  • Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells (2021, Cell Reports)
  • Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method (2020, Biomolecules)
  • CryoSIM: super-resolution 3D structured illumination cryogenic fluorescence microscopy for correlated ultrastructural imaging (2020, Optica)

Frequent coauthors collaborating with Alfredo Castello include Shabaz Mohammed, Wael Kamel, Marko Noerenberg, Louisa Iselin, and Ilan Davis.

The scientist regularly publishes in several venues, with notable counts of publications in:

  • bioRxiv (Cold Spring Harbor Laboratory) - 17 publications
  • Molecular Cell - 3 publications
  • RNA - 2 publications
  • SSRN Electronic Journal - 2 publications
  • Science - 1 publication

Best Publications

  • Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

    Alfredo Castello;Bernd Fischer;Katrin Eichelbaum;Rastislav Horos

  • A brave new world of RNA-binding proteins

    Matthias W. Hentze;Alfredo Castello;Thomas Schwarzl;Thomas Preiss

  • Comprehensive Identification of RNA-Binding Domains in Human Cells

    Alfredo Castello;Alfredo Castello;Bernd Fischer;Bernd Fischer;Christian K. Frese;Rastislav Horos

  • The RNA-binding protein repertoire of embryonic stem cells

    S Chul Kwon;Hyerim Yi;Katrin Eichelbaum;Sophia Föhr

  • The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

    Benedikt M. Beckmann;Rastislav Horos;Bernd Fischer;Bernd Fischer;Alfredo Castello;Alfredo Castello

  • hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.

    Greta Pintacuda;Guifeng Wei;Chloë Roustan;Burcu Anil Kirmizitas

  • Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins

    Alfredo Castello;Matthias W. Hentze;Thomas Preiss

  • RNA-binding proteins in Mendelian disease

    Alfredo Castello;Bernd Fischer;Matthias W. Hentze;Thomas Preiss

  • A prenylated dsRNA sensor protects against severe COVID-19.

    Arthur Wickenhagen;Elena Sugrue;Spyros Lytras;Srikeerthana Kuchi

  • System-wide identification of RNA-binding proteins by interactome capture

    Alfredo Castello;Rastislav Horos;Claudia Strein;Bernd Fischer

  • The new (dis)order in RNA regulation

    Aino I. Järvelin;Marko Noerenberg;Ilan Davis;Alfredo Castello

  • System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection

    Manuel Garcia-Moreno;Marko Noerenberg;Shuai Ni;Shuai Ni;Aino I. Järvelin

  • RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

    Nila Roy Choudhury;Gregory Heikel;Maryia Trubitsyna;Peter Kubik

  • The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy.

    Rastislav Horos;Magdalena Büscher;Rozemarijn Kleinendorst;Anne-Marie Alleaume

  • Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila

    Vasiliy O. Sysoev;Bernd Fischer;Christian K. Frese;Ishaan Gupta

  • The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease

    Yalin Liao;Alfredo Castello;Bernd Fischer;Stefan Leicht

  • Viroporins from RNA viruses induce caspase-dependent apoptosis.

    Vanessa Madan;Alfredo Castelló;Luis Carrasco

  • Global analysis of protein-RNA interactions in SARS-CoV-2 infected cells reveals key regulators of infection

    Wael Kamel;Marko Noerenberg;Marko Noerenberg;Berati Cerikan;Honglin Chen

  • RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage

    Alfredo Castelló;José M. Izquierdo;Ewelina Welnowska;Luis Carrasco

  • Global analysis of protein-RNA interactions in SARS-CoV-2 infected cells reveals key regulators of infection

    Wael Kamel;Marko Noerenberg;Berati Cerikan;Honglin Chen

Frequent Co-Authors

Matthias W. Hentze
Matthias W. Hentze European Molecular Biology Laboratory
Shabaz Mohammed
Shabaz Mohammed University of Oxford
Luis Carrasco
Luis Carrasco Centro de Biología Molecular Severo Ochoa
Jeroen Krijgsveld
Jeroen Krijgsveld German Cancer Research Center
Thomas Preiss
Thomas Preiss Australian National University
Juri Rappsilber
Juri Rappsilber Technical University of Berlin
Wolfgang Huber
Wolfgang Huber European Bioinformatics Institute
Peter J. Ratcliffe
Peter J. Ratcliffe The Francis Crick Institute
Gail M. Preston
Gail M. Preston University of Oxford
Lars M. Steinmetz
Lars M. Steinmetz Stanford University

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