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Genetics and Molecular Biology
France
2024

D-Index & Metrics

Molecular Biology

D-Index
89
Citations
28598
World Ranking
756
National Ranking
20

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in France Leader Award

Overview

Saadi Khochbin is affiliated with Grenoble Alpes University in France. The scientist's research spans across biochemistry, genetics, and molecular biology, with a notable focus on medicine. They have contributed extensively to molecular biology, public health, environmental and occupational health, genetics, hematology, and oncology.

Their research primarily addresses several key topics including:

  • Protein Degradation and Inhibitors
  • Epigenetics and DNA Methylation
  • Ubiquitin and proteasome pathways
  • Genomics and Chromatin Dynamics
  • RNA modifications and cancer
  • Histone Deacetylase Inhibitors Research
  • RNA Research and Splicing

Khochbin has published frequently in various scientific venues, with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, International Journal of Molecular Sciences, iScience, and Molecular Metabolism.

Recent publications include:

  • Structural insights into p300 regulation and acetylation-dependent genome organisation, 2022, Nature Communications
  • Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2, 2021, Cell Discovery
  • Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution, 2021, Cell Reports
  • Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions, 2020, BMC Medicine
  • The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma, 2021, British Journal of Cancer

Frequent collaborators include:

  • Sophie Rousseaux
  • Florent Chuffart
  • Ekaterina Bourovâ-Flin
  • Uwe Schlattner
  • Anne-Laure Vitte

Best Publications

  • Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

    Minjia Tan;Hao Luo;Sangkyu Lee;Fulai Jin

  • In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation.

    Akihisa Matsuyama;Tadahiro Shimazu;Yuko Sumida;Akiko Saito

  • HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

    Yu Zhang;Na Li;Cécile Caron;Gabriele Matthias

  • Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

    Yu Zhang;So Hee Kwon;Teppei Yamaguchi;Fabien Cubizolles

  • Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

    Ryohei Furumai;Yasuhiko Komatsu;Norikazu Nishino;Saadi Khochbin

  • Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

    Jeanne Morinière;Sophie Rousseaux;Ulrich Steuerwald;Montserrat Soler-López

  • Functional significance of histone deacetylase diversity

    Saadi Khochbin;André Verdel;Claudie Lemercier;Daphné Seigneurin-Berny

  • Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers

    Sophie Rousseaux;Alexandra Debernardi;Baptiste Jacquiau;Anne Laure Vitte

  • HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination.

    C Boyault;K Sadoul;M Pabion;S Khochbin

  • Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.

    Jacques Baudier;Christian Delphin;Didier Grunwald;Saadi Khochbin

  • HSP27 Is a Ubiquitin-Binding Protein Involved in I-κBα Proteasomal Degradation

    Arnaud Parcellier;Elise Schmitt;Sandeep Gurbuxani;Daphné Seigneurin-Berny

  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.

    Cyril Boyault;Yu Zhang;Sabrina Fritah;Cécile Caron

  • Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark

    Lunzhi Dai;Chao Peng;Emilie Montellier;Zhike Lu

  • Identification of Components of the Murine Histone Deacetylase 6 Complex: Link between Acetylation and Ubiquitination Signaling Pathways

    Daphnée Seigneurin-Berny;André Verdel;Sandrine Curtet;Claudie Lemercier

  • A unified phylogeny-based nomenclature for histone variants

    Paul B Talbert;Kami Ahmad;Geneviève Almouzni;Juan Ausió

  • Regulatory cross-talk between lysine acetylation and ubiquitination: role in the control of protein stability.

    Cécile Caron;Cyril Boyault;Saadi Khochbin

  • Identification of a New Family of Higher Eukaryotic Histone Deacetylases COORDINATE EXPRESSION OF DIFFERENTIATION-DEPENDENT CHROMATIN MODIFIERS

    André Verdel;Saadi Khochbin

  • The Histone Variant MacroH2A Interferes with Transcription Factor Binding and SWI/SNF Nucleosome Remodeling

    Dimitar Angelov;Annie Molla;Pierre-Yves Perche;Fabienne Hans

  • HDAC6–p97/VCP controlled polyubiquitin chain turnover

    Cyril Boyault;Benoit Gilquin;Yu Zhang;Vladimir Rybin

  • The role of histones in chromatin remodelling during mammalian spermiogenesis.

    Jérôme Govin;Cécile Caron;Cécile Lestrat;Sophie Rousseaux

Frequent Co-Authors

Sophie Rousseaux
Sophie Rousseaux Joseph Fourier University
Jérôme Garin
Jérôme Garin CEA Grenoble
Myriam Ferro
Myriam Ferro Grenoble Alpes University
Elisabeth Brambilla
Elisabeth Brambilla Grenoble Alpes University
Yingming Zhao
Yingming Zhao University of Chicago
Minoru Yoshida
Minoru Yoshida University of Tokyo
Patrick Matthias
Patrick Matthias Friedrich Miescher Institute
Stefan Dimitrov
Stefan Dimitrov Grenoble Alpes University
Christian Brambilla
Christian Brambilla Centre national de la recherche scientifique, CNRS
Lauriane Kuhn
Lauriane Kuhn Centre national de la recherche scientifique, CNRS

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