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Genetics

D-Index
50
Citations
9934
World Ranking
3927
National Ranking
18

Overview

Christian Seiser is affiliated with the Medical University of Vienna in Austria. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions also to Immunology and Microbiology.

The main subfields of study addressed by Seiser include Molecular Biology and Immunology, as well as Plant Science, Pathology and Forensic Medicine, and Cellular and Molecular Neuroscience. Their research focuses on several topics, notably Histone Deacetylase Inhibitors Research, Protein Degradation and Inhibitors, and Epigenetics and DNA Methylation.

The scientist's recent publications cover diverse themes in molecular and cellular biology. Selected papers include:

  • A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation, 2022, PLoS Genetics
  • Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation, 2020, JCI Insight
  • DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis, 2021, The EMBO Journal
  • Vorinostat in the acute neuroinflammatory form of X-linked adrenoleukodystrophy, 2020, Annals of Clinical and Translational Neurology
  • Targeting foam cell formation in inflammatory brain diseases by the histone modifier MS-275, 2020, Annals of Clinical and Translational Neurology

Christian Seiser frequently collaborates with other researchers. Their frequent co-authors include Gerda Egger, Terezia Vcelkova, Wilfried Ellmeier, Christoph Bock, and Raheleh Sheibani-Tezerji.

The scientist's work is often published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Annals of Clinical and Translational Neurology, eLife, PLoS Genetics, and The EMBO Journal.

Best Publications

  • Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.

    F Grignani;S De Matteis;Clara Nervi;L Tomassoni

  • Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

    Gerda Lagger;Dónal O'Carroll;Martina Rembold;Harald Khier

  • Histone deacetylase 1 can repress transcription by binding to Sp1.

    Angelika Doetzlhofer;Hans Rotheneder;Gerda Lagger;Manfred Koranda

  • Negative and positive regulation of gene expression by mouse histone deacetylase 1.

    Gordin Zupkovitz;Julia Tischler;Markus Posch;Iwona Sadzak

  • Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression

    Teppei Yamaguchi;Fabien Cubizolles;Yu Zhang;Nina Reichert

  • Role for histone deacetylase 1 in human tumor cell proliferation

    Silvia Senese;Katrin Zaragoza;Simone Minardi;Ivan Muradore

  • The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.

    Gerda Lagger;Angelika Doetzlhofer;Bernd Schuettengruber;Eva Haidweger

  • Histone H3 phosphorylation - a versatile chromatin modification for different occasions.

    Anna Sawicka;Christian Seiser

  • Histone deacetylase 1 and 2-controlled embryonic development and cell differentiation

    Reinhard Brunmeir;Sabine Lagger;Christian Seiser

  • Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements

    B R Henderson;C Seiser;L C Kühn

  • 14‐3‐3 Proteins recognize a histone code at histone H3 and are required for transcriptional activation

    Stefan Winter;Elisabeth Simboeck;Wolfgang Fischle;Gordin Zupkovitz

  • The Cyclin-Dependent Kinase Inhibitor p21 Is a Crucial Target for Histone Deacetylase 1 as a Regulator of Cellular Proliferation

    Gordin Zupkovitz;Reinhard Grausenburger;Reinhard Brunmeir;Silvia Senese

  • Identification of mouse histone deacetylase 1 as a growth factor-inducible gene.

    Stefan Bartl;Jan Taplick;Gerda Lagger;Harald Khier

  • Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.

    Vladislav Kurtev;Raphael Margueron;Karin Kroboth;Egon Ogris

  • Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis.

    Jennifer Jurkin;Gordin Zupkovitz;Sabine Lagger;Reinhard Grausenburger

  • Conditional Deletion of Histone Deacetylase 1 in T Cells Leads to Enhanced Airway Inflammation and Increased Th2 Cytokine Production

    Reinhard Grausenburger;Ivan Bilic;Nicole Boucheron;Gordin Zupkovitz

  • Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-γ-inducible gbp2 gene

    Katrin Ramsauer;Matthias Farlik;Gordin Zupkovitz;Christian Seiser

  • Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1.

    Jan Taplick;Vladislav Kurtev;Karin Kroboth;Markus Posch

  • The Biology of HDAC in Cancer: The Nuclear and Epigenetic Components

    Astrid Hagelkruys;Anna Sawicka;Magdalena Rennmayr;Christian Seiser

  • MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain.

    Sabine Lagger;John C. Connelly;Gabriele Schweikert;Shaun Webb

Frequent Co-Authors

Patrick Matthias
Patrick Matthias Friedrich Miescher Institute
Wilfried Ellmeier
Wilfried Ellmeier Medical University of Vienna
Lukas C. Kühn
Lukas C. Kühn École Polytechnique Fédérale de Lausanne
Christoph Bock
Christoph Bock Austrian Academy of Sciences
Gerald Brosch
Gerald Brosch Innsbruck Medical University
Günter Steiner
Günter Steiner Medical University of Vienna
Yu Zhang
Yu Zhang Peking University
Thomas Decker
Thomas Decker University of Vienna
Karl Mechtler
Karl Mechtler Research Institute of Molecular Pathology
Matthew Cotten
Matthew Cotten Wellcome Sanger Institute

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