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Genetics

D-Index
75
Citations
30720
World Ranking
1874
National Ranking
858

Overview

Benjamin Tycko is affiliated with the Hackensack University Medical Center in the United States. Their research spans several fields with a primary focus on Medicine, supported by significant work in Biochemistry, Genetics, and Molecular Biology.

The main topics of Benjamin Tycko's research include:

  • Epigenetics and DNA Methylation
  • Down syndrome and intellectual disability research
  • Chronic Disease Management Strategies
  • Dementia and Cognitive Impairment Research
  • RNA modifications and cancer
  • Immune cells in cancer
  • Frailty in Older Adults

The scientist's subfields of study cover Molecular Biology, Public Health, Environmental and Occupational Health, Immunology, Oncology, and Epidemiology. These areas indicate a multidisciplinary approach involving molecular mechanisms and population health.

Benjamin Tycko has published extensively, with many papers appearing in venues such as Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring, The Lancet Neurology, and Bioinformatics. Cancer Research is the most frequent publication venue.

Some of the recent papers authored by or co-authored by Benjamin Tycko include:

  • "A DNA Hypomethylating Drug Alters the Tumor Microenvironment and Improves the Effectiveness of Immune Checkpoint Inhibitors in a Mouse Model of Pancreatic Cancer" (2020, Cancer Research)
  • "Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study" (2022, The Lancet Neurology)
  • "Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome" (2020, Journal of Alzheimer s Disease)
  • "PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression" (2024, Cell Metabolism)
  • "Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs" (2020, Genome biology)

Frequent co-authors of Benjamin Tycko include Catherine Do, Joseph H. Lee, Nicole Schupf, Sharon J. Krinsky-McHale, and Wayne Silverman. These collaborations indicate ongoing interdisciplinary work and joint contributions to research in genetics, neurology, and oncology.

Best Publications

  • PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

    Jing Li;Clifford Yen;Danny Liaw;Katrina Podsypanina

  • The history of cancer epigenetics.

    Andrew P. Feinberg;Benjamin Tycko

  • Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.

    Michael Quante;Shui Ping Tu;Shui Ping Tu;Hiroyuki Tomita;Tamas Gonda

  • Rapid acidification of endocytic vesicles containing α2-macroglobulin

    Benjamin Tycko;Frederick R. Maxfield

  • Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease

    R. Mayeux;R. Ottman;G. Maestre;C. Ngai

  • Tumour-suppressor activity of H19 RNA

    Yue Hao;Taria Crenshaw;Thomas Moulton;Elizabeth Newcomb

  • Segregation of transferrin to a mildly acidic (pH 6.5) para-golgi compartment in the recycling pathway

    Darrell J. Yamashiro;Benjamin Tycko;Sharon R. Fluss;Frederick R. Maxfield

  • Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation

    Kristi Kerkel;Alexandra Spadola;Eric Yuan;Jolanta Kosek

  • Regulation of supply and demand for maternal nutrients in mammals by imprinted genes

    Wolf Reik;Miguel Constância;Abigail Fowden;Neil Anderson

  • Monoallelic expression of the human H19 gene.

    Yonghui Zhang;Benjamin Tycko

  • Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation.

    A. J. C. Slooter;M.-X. Tang;C. M. Van Duijn;Y. Stern

  • Physiological functions of imprinted genes.

    Benjamin Tycko;Ian M. Morison

  • Creation of genomic methylation patterns.

    Timothy H. Bestor;Benjamin Tycko

  • Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation

    Catherine A Lynch;Benjamin Tycko;Timothy H Bestor;Colum P Walsh

  • Unbalanced placental expression of imprinted genes in human intrauterine growth restriction.

    J. McMinn;M. Wei;N. Schupf;J. Cusmai

  • Epigenetic lesions at the H19 locus in Wilms' tumour patients.

    Thomas Moulton;Taria Crenshaw;Yue Hao;Josh Moosikasuwan

  • Apolipoprotein E and alzheimer's disease: Ethnic variation in genotypic risks

    Gladys Maestre;Gladys Maestre;Ruth Ottman;Yaakov Stern;Barry J. Gurland;Barry J. Gurland

  • Gene Expression in Wilms’ Tumor Mimics the Earliest Committed Stage in the Metanephric Mesenchymal-Epithelial Transition

    Chi-Ming Li;Meirong Guo;Alain Borczuk;Charles A. Powell

  • Down syndrome and Alzheimer's disease: Common pathways, common goals.

    Dean Hartley;Thomas Blumenthal;Maria Carrillo;Gilbert DiPaolo

  • Epigenetic gene silencing in cancer

    Benjamin Tycko

Frequent Co-Authors

Richard Mayeux
Richard Mayeux Columbia University
Nicole Schupf
Nicole Schupf Columbia University
Yaakov Stern
Yaakov Stern Columbia University
Ming-Xin Tang
Ming-Xin Tang Columbia University
Vundavalli V. Murty
Vundavalli V. Murty Columbia University Medical Center
Timothy C. Wang
Timothy C. Wang Columbia University
Ekaterina Rogaeva
Ekaterina Rogaeva University of Toronto
Frederick R. Maxfield
Frederick R. Maxfield Cornell University
Timothy H. Bestor
Timothy H. Bestor Columbia University
Peter St George-Hyslop
Peter St George-Hyslop Columbia University

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