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Edward B. Leof

Edward B. Leof

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
11850
World Ranking
13827
National Ranking
5850

Overview

Edward B. Leof is affiliated with the Mayo Clinic in the United States. Their research primarily focuses on medicine, with significant contributions in the fields of biochemistry, genetics, and molecular biology. Their subfields include pulmonary and respiratory medicine, molecular biology, epidemiology, immunology, and cell biology.

Leof's scientific work covers several key topics: interstitial lung diseases and idiopathic pulmonary fibrosis, developmental biology and gene regulation, TGF-β signaling in diseases, medical imaging and pathology studies, pleural and pulmonary diseases, neonatal respiratory health research, and autophagy in disease and therapy.

The frequent venues where Leof publishes include:

  • The FASEB Journal
  • Cells
  • PLoS Biology
  • The Journal of Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)

Notable recent papers authored or coauthored by Leof are:

  • IPF pathogenesis is dependent upon TGFβ induction of IGF-1, 2020, The FASEB Journal
  • SIRT7-mediated modulation of glutaminase 1 regulates TGF-β-induced pulmonary fibrosis, 2020, The FASEB Journal
  • Vardenafil Activity in Lung Fibrosis and In Vitro Synergy with Nintedanib, 2021, Cells
  • A juxtamembrane basolateral targeting motif regulates signaling through a TGF-β pathway receptor in Drosophila, 2022, PLoS Biology
  • Transforming growth factor beta induced PD-L1 expression promotes pro-fibrotic signaling, 2020, The Journal of Immunology

Frequent coauthors collaborating with Leof include Jeong Han Kang, Malay Choudhury, Andrew H. Limper, Aidan J. Peterson, and Stephen J. Murphy.

Best Publications

  • Growth Factors and Cancer

    Anton Scott Goustin;Edward B. Leof;Gary D. Shipley;Harold L. Moses

  • Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

    Craig E. Daniels;Mark C. Wilkes;Maryanne Edens;Ted J. Kottom

  • Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor β: A proposed model for indirect mitogenesis involving autocrine activity

    Edward B. Leof;Jacqueline A. Proper;Anton Scott Goustin;Gary D. Shipley

  • Imatinib mesylate blocks a non-Smad TGF-β pathway and reduces renal fibrogenesis in vivo

    Shinong Wang;Mark C. Wilkes;Edward B. Leof;Raimund Hirschberg

  • Suramin inhibition of growth factor receptor binding and mitogenicity in AKR‐2B cells

    Robert J. Coffey;Edward B. Leof;Gary D. Shipley;Harold L. Moses

  • TGF‐β signaling: A tale of two responses

    Rod A. Rahimi;Edward B. Leof

  • Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells.

    Edward B. Leof;Walker Wharton;Judson J. Van Wyk;W.J. Pledger

  • Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest.

    Philip H. Howe;Giulio Draetta;Edward B. Leof

  • Ligand-dependent and -independent Transforming Growth Factor-β Receptor Recycling Regulated by Clathrin-mediated Endocytosis and Rab11

    Hugh Mitchell;Amit Choudhury;Richard E. Pagano;Edward B. Leof

  • Transforming Growth Factor-β Activation of Phosphatidylinositol 3-Kinase Is Independent of Smad2 and Smad3 and Regulates Fibroblast Responses via p21-Activated Kinase-2

    Mark C. Wilkes;Hugh Mitchell;Sumedha Gulati Penheiter;Jules J. Doré

  • Internalization-Dependent and -Independent Requirements for Transforming Growth Factor β Receptor Signaling via the Smad Pathway

    Sumedha G. Penheiter;Hugh Mitchell;Nandor Garamszegi;Maryanne Edens

  • Transforming growth factor β regulation of cell proliferation

    Harold L. Moses;Robert J. Coffey;Edward B. Leof;Russette M. Lyons

  • Transforming growth factors and control of neoplastic cell growth.

    Jorma Keski‐Oja;Edward B. Leof;Russette M. Lyons;Robert J. Coffey

  • Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

    Sheng Cao;Usman Yaqoob;Amitava Das;Uday Shergill

  • Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

    Mark C. Wilkes;Stephen J. Murphy;Nandor Garamszegi;Edward B. Leof

  • Noncanonical TGF-β pathways, mTORC1 and Abl, in renal interstitial fibrogenesis

    Shinong Wang;Mark C. Wilkes;Edward B. Leof;Raimund Hirschberg

  • Transforming growth factor-β receptors interact with AP2 by direct binding to β2 subunit

    Diying Yao;Marcelo Ehrlich;Yoav I. Henis;Edward B. Leof

  • Regulation of the synthesis and activity of urokinase plasminogen activator in A549 human lung carcinoma cells by transforming growth factor-beta

    J Keski-Oja;F Blasi;EB Leof;HL Moses

  • Platelet-Derived Growth Factor Signaling Through Ephrin-B2 Regulates Hepatic Vascular Structure and Function

    David Semela;David Semela;Amitava Das;Daniel Langer;Ningling Kang

  • Transforming growth factor type β regulation of actin mRNA

    Edward B. Leof;Jacqueline A. Proper;Michael J. Getz;Harold L. Moses

Frequent Co-Authors

Andrew H. Limper
Andrew H. Limper Mayo Clinic
Harold L. Moses
Harold L. Moses Vanderbilt University
Robert J. Coffey
Robert J. Coffey Vanderbilt University Medical Center
Santanu Bhattacharya
Santanu Bhattacharya Indian Institute of Science
John Varga
John Varga University of Michigan–Ann Arbor
Jorma Keski-Oja
Jorma Keski-Oja University of Helsinki
Alain Mauviel
Alain Mauviel Institute Curie
Ruth Lupu
Ruth Lupu Mayo Clinic

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