World's Best Scientists 2026 revealed!
Jean-Christophe Marine

Jean-Christophe Marine

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Molecular Biology
Belgium
2026

D-Index & Metrics

Molecular Biology

D-Index
90
Citations
44278
World Ranking
729
National Ranking
8

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Belgium Leader Award
  • 2025 - Research.com Molecular Biology in Belgium Leader Award
  • 2023 - Research.com Molecular Biology in Belgium Leader Award

Overview

Jean-Christophe Marine is a researcher affiliated with KU Leuven in Belgium whose work spans multiple domains within biochemistry, genetics, molecular biology, and medicine. The scientist's research portfolio comprises a significant number of publications, focusing on molecular biology, oncology, immunology, cancer research, and cell biology.

The principal research topics covered by Jean-Christophe Marine include:

  • Immunotherapy and Immune Responses
  • Single-cell and spatial transcriptomics
  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • Melanoma and MAPK Pathways
  • Cancer Cells and Metastasis
  • Immune cells in cancer

Frequently collaborating with other scientists, Marine has coauthored numerous papers with Florian Rambow, Joanna Poźniak, Panagiotis Karras, Oliver Bechter, and Francesca M. Bosisio, reflecting interdisciplinary and teamwork-driven research endeavors.

Marine's work is published extensively in high-impact venues, with noted recurrent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Cancer Cell
  • Cancer Discovery
  • Nature Cancer

Some of the recent significant publications include:

  • Non-genetic mechanisms of therapeutic resistance in cancer, 2020, Nature Reviews. Cancer
  • Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma, 2020, Nature Cell Biology
  • CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours, 2023, Nature
  • A cellular hierarchy in melanoma uncouples growth and metastasis, 2022, Nature
  • Melanoma models for the next generation of therapies, 2021, Cancer Cell

The research carried out by Jean-Christophe Marine addresses complex biological mechanisms underlying cancer progression, immune evasion, and therapeutic resistance, with a strong emphasis on melanoma and immunotherapy approaches. This focus contributes to the understanding of cancer cell behavior, immune interactions, and potential therapeutic strategies.

The comprehensive body of work, spanning molecular biology to applied oncology, integrates advanced techniques such as single-cell transcriptomics and explores novel avenues in cancer immunotherapy, including CAR-T cell therapy and biomarker discovery.

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • SCENIC: single-cell regulatory network inference and clustering.

    Sara Aibar;Carmen Bravo González-Blas;Thomas Moerman;Vân Anh Huynh-Thu

  • Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

    Evan Parganas;Demin Wang;Dimitrios Stravopodis;David J. Topham

  • Identification of the tumour transition states occurring during EMT

    Ievgenia Pastushenko;Audrey Brisebarre;Alejandro Sifrim;Alejandro Sifrim;Marco Fioramonti

  • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

    L. Galluzzi;J. M. Bravo-San Pedro;I. Vitale;S. A. Aaronson

  • The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

    Adrian P. Bracken;Daniela Kleine-Kohlbrecher;Nikolaj Dietrich;Diego Pasini

  • iRegulon: from a gene list to a gene regulatory network using large motif and track collections.

    Rekin's Janky;Annelien Verfaillie;Hana Imrichová;Bram Van de Sande

  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

    L. Galluzzi;L. Galluzzi;L. Galluzzi;S. A. Aaronson;J. Abrams;E. S. Alnemri

  • Inactivation of the p53 pathway in retinoblastoma

    Nikia A. Laurie;Stacy L. Donovan;Chie Schin Shih;Jiakun Zhang

  • Nucleophosmin regulates the stability and transcriptional activity of p53.

    Emanuela Colombo;Jean Christophe Marine;Davide Danovi;Brunangelo Falini

  • SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

    Jean Christophe Marine;David J. Topham;Catriona McKay;Demin Wang

  • Interrogating open issues in cancer precision medicine with patient-derived xenografts

    Annette T. Byrne;Denis G. Alférez;Frédéric Amant;Daniela Annibali

  • Toward Minimal Residual Disease-Directed Therapy in Melanoma.

    Florian Rambow;Aljosja Rogiers;Oskar Marin-Bejar;Sara Aibar

  • Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

    Demin Wang;Jian Feng;Jian Feng;Renren Wen;Jean-Christophe Marine

  • Melanoma addiction to the long non-coding RNA SAMMSON.

    Eleonora Leucci;Roberto Vendramin;Marco Spinazzi;Patrick Laurette

  • Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

    Jie Xu;Joke Reumers;José R Couceiro;Frederik De Smet

  • SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

    Jean Christophe Marine;Catriona McKay;Demin Wang;David J. Topham

  • Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

    Jean-Christophe Marine;Sarah Francoz;Marion Maetens;G Wahl

  • Mdm2-mediated ubiquitylation: p53 and beyond

    Jean-Christophe Marine;G Lozano

  • p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

    Carmen Adriaens;Laura Standaert;Jasmine Barra;Mathilde Latil

Frequent Co-Authors

Aart G. Jochemsen
Aart G. Jochemsen Leiden University Medical Center
Stein Aerts
Stein Aerts KU Leuven
James N. Ihle
James N. Ihle St. Jude Children's Research Hospital
Pier Giuseppe Pelicci
Pier Giuseppe Pelicci European Institute of Oncology
Jo Vandesompele
Jo Vandesompele Ghent University
Cédric Blanpain
Cédric Blanpain Université Libre de Bruxelles
Oliver Kepp
Oliver Kepp Institut Gustave Roussy
Thierry Voet
Thierry Voet KU Leuven
Demin Wang
Demin Wang Medical College of Wisconsin

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