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D-Index & Metrics

Molecular Biology

D-Index
60
Citations
13589
World Ranking
1954
National Ranking
47

Overview

Aart G. Jochemsen is affiliated with Leiden University Medical Center in the Netherlands. Their work largely spans biochemistry, genetics, and molecular biology with a notable focus on medicine. The scientist's research interests include molecular biology, ophthalmology, oncology, immunology, and cancer research.

Their primary research topics cover ocular oncology and treatments, epigenetics and DNA methylation, cancer-related molecular pathways, histone deacetylase inhibitors research, cancer-related molecular mechanisms research, Hippo pathway signaling and YAP/TAZ, and interferon and immune responses.

The scientist has contributed to several research papers, including:

  • HDAC Inhibition Increases HLA Class I Expression in Uveal Melanoma, 2020, published in Cancers
  • The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival, 2021, published in Oncogene
  • Analysis of CRISPR-Cas9 screens identifies genetic dependencies in melanoma, 2020, published in Pigment Cell & Melanoma Research
  • Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma, 2020, published in European Journal of Cancer
  • Mdm4 supports DNA replication in a p53-independent fashion, 2020, published in Oncogene

Frequent publication venues for Aart G. Jochemsen include:

  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Oncogene
  • European Journal of Cancer
  • Acta Ophthalmologica

The scientist has collaborated regularly with several co-authors, including:

  • Fariba Némati
  • Martine J. Jager
  • Didier Decaudin
  • Amina F.A.S. Teunisse
  • Samar Alsafadi

Best Publications

  • MDMX: A novel p53-binding protein with some functional properties of MDM2

    A. Shvarts;W. T. Steegenga;N. Riteco;T. Van Laar

  • Rescue of embryonic lethality in Mdm4 -null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

    John Parant;Arturo Chavez-Reyes;Arturo Chavez-Reyes;Natalie A. Little;Wen Yan

  • Inactivation of the p53 pathway in retinoblastoma

    Nikia A. Laurie;Stacy L. Donovan;Chie Schin Shih;Jiakun Zhang

  • WT1 proteins: functions in growth and differentiation.

    V Volkher Scharnhorst;AJ van der Eb;AG Jochemsen

  • Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

    Davide Danovi;Erik Meulmeester;Diego Pasini;Domenico Migliorini

  • Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development

    Domenico Migliorini;Eros Lazzerini Denchi;Davide Danovi;Aart Jochemsen

  • Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53

    Jijie Gu;Hidehiko Kawai;Linghu Nie;Hiroyuki Kitao

  • MDM4 is a key therapeutic target in cutaneous melanoma

    Agnieszka Gembarska;Agnieszka Gembarska;Flavie Luciani;Flavie Luciani;Clare Fedele;Clare Fedele;Elisabeth A Russell

  • Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines

    Antoinette Hollestelle;Jord H. A. Nagel;Marcel Smid;Suzanne Lam

  • Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

    Erik Meulmeester;Madelon M. Maurice;Chris Boutell;Amina F.A.S. Teunisse

  • MDMX: from bench to bedside.

    Jean-Christophe W. Marine;Michael A. Dyer;Aart G. Jochemsen

  • Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms.

    Robert Stad;Natalie A Little;Dimitris P Xirodimas;Ruth Frenk

  • The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells.

    Wilma T Steegenga;Nicole Riteco;A G Jochemsen;Frits J Fallaux

  • Mdmx as an essential regulator of p53 activity

    Jean-Christophe Marine;Aart G. Jochemsen

  • Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

    Yaron Pereg;Dganit Shkedy;Petra de Graaf;Erik Meulmeester

  • Comparative study of the p53-mdm2 and p53-MDMX interfaces

    V. Böttger;A. Böttger;C. Garcia-Echeverria;Y. F. M. Ramos

  • Identification and Characterization of the First Small Molecule Inhibitor of MDMX

    Damon Reed;Ying Shen;Anang A. Shelat;Leggy A. Arnold

  • p53: a guide to apoptosis.

    Erik Meulmeester;Aart G Jochemsen

  • ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation.

    Erik Meulmeester;Yaron Pereg;Yosef Shiloh;Aart G. Jochemsen

  • Apoptin, a protein derived from chicken anemia virus, induces p53-independent apoptosis in human osteosarcoma cells

    Shi-Mei Zhuang;A. Shvarts;H. Van Ormondt;A. G. Jochemsen

Frequent Co-Authors

A. J. Van Der Eb
A. J. Van Der Eb Leiden University
Martine J. Jager
Martine J. Jager Leiden University Medical Center
Karoly Szuhai
Karoly Szuhai Leiden University Medical Center
Pancras C.W. Hogendoorn
Pancras C.W. Hogendoorn Leiden University Medical Center
Ygal Haupt
Ygal Haupt Peter MacCallum Cancer Centre
Michael A. Dyer
Michael A. Dyer St. Jude Children's Research Hospital
René Bernards
René Bernards Antoni van Leeuwenhoek Hospital
Yosef Shiloh
Yosef Shiloh Tel Aviv University
Marco J. Herold
Marco J. Herold Walter and Eliza Hall Institute of Medical Research

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