Aart G. Jochemsen focuses on MDMX, Cancer research, Mdm2, Cell biology and Proto-Oncogene Proteins c-mdm2. His Cancer research research integrates issues from Carcinogenesis, Tumor suppressor gene, Mutation, Downregulation and upregulation and Retinoblastoma. Aart G. Jochemsen has included themes like Regulator, Ubiquitin ligase, Transfection and Nuclear export signal in his Mdm2 study.
His Cell biology research incorporates elements of Nuclear protein, Transcription, Transactivation and Mutant. Aart G. Jochemsen interconnects Molecular biology and Ubiquitin in the investigation of issues within Nuclear protein. His work in Proto-Oncogene Proteins c-mdm2 addresses subjects such as Ring finger, which are connected to disciplines such as Zinc finger.
His main research concerns Cancer research, Cell biology, Molecular biology, MDMX and Mdm2. His Cancer research research includes elements of Tumor suppressor gene, Apoptosis, Cell cycle and Cell culture. The concepts of his Cell biology study are interwoven with issues in Ubiquitin, Mutant, DNA damage and Biochemistry.
His Molecular biology study combines topics from a wide range of disciplines, such as Gene expression, Transfection, Gene, Transcription and Gene isoform. In his research on the topic of MDMX, Ring finger is strongly related with Proto-Oncogene Proteins c-mdm2. His Mdm2 study combines topics in areas such as Retinoblastoma, Regulator and Ubiquitin ligase.
Aart G. Jochemsen spends much of his time researching Cancer research, Melanoma, Cell growth, Cell culture and Gene. His Cancer research research is multidisciplinary, incorporating perspectives in Gene knockdown, Phenotype, Inflammation, Mdm2 and Metastasis. His research on Mdm2 also deals with topics like
His studies in Melanoma integrate themes in fields like Apoptosis and Malignancy. His studies deal with areas such as Origin of replication, DNA Replication Fork, DNA, Protein kinase C and MDMX as well as Cell growth. His work investigates the relationship between Growth inhibition and topics such as Carcinogenesis that intersect with problems in Cell biology.
His main research concerns Melanoma, Cancer research, Cutaneous melanoma, Conjunctival Melanoma and Clinical trial. His study in Melanoma is interdisciplinary in nature, drawing from both Phenotype, Inflammation, RELB, Downregulation and upregulation and Human leukocyte antigen. His work carried out in the field of Cancer research brings together such families of science as NFKB1, Mutant, Immune system, Growth inhibition and Cell cycle.
His research integrates issues of Position paper, Internal medicine, Disease, Etiology and Mucosal melanoma in his study of Cutaneous melanoma. His research in Conjunctival Melanoma intersects with topics in Protein kinase B, MEK inhibitor and Pathology. The study incorporates disciplines such as Viability assay, Apoptosis, Cyclin-dependent kinase and Adverse effect in addition to Clinical trial.
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MDMX: A novel p53-binding protein with some functional properties of MDM2
A. Shvarts;W. T. Steegenga;N. Riteco;T. Van Laar.
The EMBO Journal (1996)
Rescue of embryonic lethality in Mdm4 -null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
John Parant;Arturo Chavez-Reyes;Arturo Chavez-Reyes;Natalie A. Little;Wen Yan.
Nature Genetics (2001)
Inactivation of the p53 pathway in retinoblastoma
Nikia A. Laurie;Stacy L. Donovan;Chie Schin Shih;Jiakun Zhang.
WT1 proteins: functions in growth and differentiation.
V Volkher Scharnhorst;AJ van der Eb;AG Jochemsen.
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
Davide Danovi;Erik Meulmeester;Diego Pasini;Domenico Migliorini.
Molecular and Cellular Biology (2004)
Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development
Domenico Migliorini;Eros Lazzerini Denchi;Davide Danovi;Aart Jochemsen.
Molecular and Cellular Biology (2002)
MDM4 is a key therapeutic target in cutaneous melanoma
Agnieszka Gembarska;Agnieszka Gembarska;Flavie Luciani;Flavie Luciani;Clare Fedele;Clare Fedele;Elisabeth A Russell.
Nature Medicine (2012)
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
Erik Meulmeester;Madelon M. Maurice;Chris Boutell;Amina F.A.S. Teunisse.
Molecular Cell (2005)
MDMX: from bench to bedside.
Jean-Christophe W. Marine;Michael A. Dyer;Aart G. Jochemsen.
Journal of Cell Science (2007)
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines
Antoinette Hollestelle;Jord H. A. Nagel;Marcel Smid;Suzanne Lam.
Breast Cancer Research and Treatment (2010)
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