World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
14108
World Ranking
8312
National Ranking
280

Overview

Norbert B. Ghyselinck is affiliated with the Institute of Genetics and Molecular and Cellular Biology in France. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine.

Their work covers a range of subfields including Molecular Biology, Genetics, Reproductive Medicine, Public Health, Environmental and Occupational Health, as well as Cell Biology.

Major research topics addressed by Ghyselinck include:

  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Retinoids in leukemia and cellular processes
  • Sperm and Testicular Function
  • Reproductive Biology and Fertility
  • Sexual Differentiation and Disorders
  • Renal and related cancers
  • Epigenetics and DNA Methylation

Their recent scientific publications demonstrate engagement with developmental biology, stem cell identity regulation, and retinoic acid signaling pathways:

  • Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad, 2022, Science Advances
  • Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity, 2021, Cell stem cell
  • Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors, 2020, Science Advances
  • Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary, 2020, Science Advances
  • Local retinoic acid signaling directs emergence of the extraocular muscle functional unit, 2020, PLoS Biology

Ghyselinck frequently collaborates with other researchers, including Betty Féret, Diana Condrea, Muriel Klopfenstein, Serge Nef, and Nadège Vernet.

Their work has been published repeatedly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Science Advances, Biomedicines, Cell stem cell, and PLoS Biology.

Best Publications

  • FUNCTION OF RETINOID NUCLEAR RECEPTORS: Lessons from Genetic and Pharmacological Dissections of the Retinoic Acid Signaling Pathway During Mouse Embryogenesis

    Manuel Mark;Norbert B Ghyselinck;Pierre Chambon

  • Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development

    Philippe Kastner;Manuel Mark;Norbert Ghyselinck;Wojciech Krezel

  • A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse

    Frank Schnütgen;Nathalie Doerflinger;Cécile Calléja;Olivia Wendling

  • Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

    Jonathan A. Hill;Jason A. Hall;Jason A. Hall;Cheng-Ming Sun;Qi Cai

  • Function of retinoic acid receptors during embryonic development

    Manuel Mark;Norbert B. Ghyselinck;Pierre Chambon

  • Impaired Locomotion and Dopamine Signaling in Retinoid Receptor Mutant Mice

    Wojciech Krȩ Ż El;Norbert Ghyselinck;Tarek A. Samad;Valerie Dupe

  • Cellular retinol-binding protein I is essential for vitamin A homeostasis.

    Norbert B. Ghyselinck;Claes Båvik;Vincent Sapin;Manuel Mark

  • A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment

    Valérie Dupé;Nicolas Matt;Jean-Marie Garnier;Pierre Chambon

  • Retinoic acid signaling pathways.

    Norbert B. Ghyselinck;Gregg Duester

  • Role of the retinoic acid receptor beta (RARbeta) during mouse development.

    N B Ghyselinck;V Dupe;A Dierich;N Messaddeq

  • Retinoic Acid Metabolism and Signaling Pathways in the Adult and Developing Mouse Testis

    Nadège Vernet;Christine Dennefeld;Cécile Rochette-Egly;Mustapha Oulad-Abdelghani

  • Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells

    Nicolas Matt;Valérie Dupé;Jean-Marie Garnier;Christine Dennefeld

  • STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation

    Manuel Mark;Hugues Jacobs;Mustapha Oulad-Abdelghani;Christine Dennefeld

  • Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.

    Mathilde Raverdeau;Aurore Gely-Pernot;Betty Féret;Christine Dennefeld

  • Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes

    P. Kastner;N. Messaddeq;M. Mark;O. Wendling

  • Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse.

    Valérie Dupé;Norbert B. Ghyselinck;Olivia Wendling;Pierre Chambon

  • Genomewide production of multipurpose alleles for the functional analysis of the mouse genome

    Frank Schnütgen;Silke De-Zolt;Petra Van Sloun;Melanie Hollatz

  • FOXL2 Is a Female Sex-Determining Gene in the Goat

    Laurent Boulanger;Maëlle Pannetier;Laurence Gall;Aurélie Allais-Bonnet

  • Physiological and retinoid‐induced proliferations of epidermis basal keratinocytes are differently controlled

    Benoit Chapellier;Manuel Mark;Nadia Messaddeq;Cécile Calléja

  • Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning

    Olivia Wendling;Norbert B. Ghyselinck;Pierre Chambon;Manuel Mark

Frequent Co-Authors

Pierre Chambon
Pierre Chambon Institute of Genetics and Molecular and Cellular Biology
Manuel Mark
Manuel Mark Institute of Genetics and Molecular and Cellular Biology
Pascal Dollé
Pascal Dollé Institute of Genetics and Molecular and Cellular Biology
Philippe Kastner
Philippe Kastner Institute of Genetics and Molecular and Cellular Biology
Nadia Messaddeq
Nadia Messaddeq Institute of Genetics and Molecular and Cellular Biology
Andrée Dierich
Andrée Dierich Institute of Genetics and Molecular and Cellular Biology
Celso E. Gomez-Sanchez
Celso E. Gomez-Sanchez University of Mississippi Medical Center
Dean Bok
Dean Bok University of California, Los Angeles
Andreas Schedl
Andreas Schedl Grenoble Alpes University
Enzo Lalli
Enzo Lalli Centre national de la recherche scientifique, CNRS

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Norbert B. Ghyselinck

Trending Scientists