World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
15516
World Ranking
5161
National Ranking
2457

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

His main research concerns Retinoic acid, Biochemistry, Retinoid, Retinol and Tretinoin. His studies in Retinoic acid integrate themes in fields like Endocrinology, Internal medicine, Retinol binding protein, Colorectal cancer and Cell biology. He works mostly in the field of Retinol binding protein, limiting it down to topics relating to NAD+ kinase and, in certain cases, Vitamin.

His biological study spans a wide range of topics, including Immune system, Chromatography, Endogeny, Flux and Isozyme. His study focuses on the intersection of Retinol and fields such as Retinal with connections in the field of Orders of magnitude and Adipose tissue. The study incorporates disciplines such as Retinoic acid receptor, Biogenesis, Signal transduction and Lecithin retinol acyltransferase in addition to Tretinoin.

His most cited work include:

  • Interactions of retinoid binding proteins and enzymes in retinoid metabolism. (372 citations)
  • Physiological insights into all-trans-retinoic acid biosynthesis (230 citations)
  • Quantification of endogenous retinoic acid in limited biological samples by LC/MS/MS (154 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Retinoic acid, Biochemistry, Retinoid, Internal medicine and Endocrinology. His Retinoic acid research is multidisciplinary, incorporating elements of Endogeny and Cell biology. His Biochemistry and Retinol, Vitamin, Retinal, Dehydrogenase and Metabolite investigations all form part of his Biochemistry research activities.

His Retinol research incorporates elements of Adipose tissue and Chromatography, Resolution. Joseph L. Napoli mostly deals with Retinoid binding protein in his studies of Retinoid. His research integrates issues of Immune system, FOXP3 and Toxicity in his study of Endocrinology.

He most often published in these fields:

  • Retinoic acid (55.67%)
  • Biochemistry (49.48%)
  • Retinoid (28.87%)

What were the highlights of his more recent work (between 2014-2020)?

  • Retinoic acid (55.67%)
  • Retinoid (28.87%)
  • Retinol (20.62%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Retinoic acid, Retinoid, Retinol, Biochemistry and Cell biology. His work on CYP26A1 as part of general Retinoic acid research is frequently linked to Fluconazole, thereby connecting diverse disciplines of science. His Retinoid research is multidisciplinary, relying on both Regenerative medicine, Metabolic regulation and Drug delivery.

His Retinol research includes elements of Detection limit, Chromatography and Retinal. His Biochemistry research focuses on Mass spectrometry and how it relates to Adipose tissue. In his research, Retinoid X receptor alpha, Retinoid X receptor beta, Retinoic acid receptor, Tretinoin and Retinoid X receptor gamma is intimately related to Retinoid binding protein, which falls under the overarching field of Cell biology.

Between 2014 and 2020, his most popular works were:

  • Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell-Mediated Immunity in Colorectal Cancer (73 citations)
  • Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake. (41 citations)
  • Functions of Intracellular Retinoid Binding-Proteins. (27 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Metabolism

Joseph L. Napoli spends much of his time researching Retinoic acid, CYP26A1, Carcinogenesis, Cancer research and Immune system. As part of his studies on Retinoic acid, he often connects relevant areas like Cell biology. His Cancer research study combines topics from a wide range of disciplines, such as Downregulation and upregulation, CD8, Immunity, Cytotoxic T cell and Colorectal cancer.

His Immune system study combines topics in areas such as Inflammation, Cancer and Familial adenomatous polyposis.

Best Publications

  • Interactions of retinoid binding proteins and enzymes in retinoid metabolism.

    Joseph L Napoli

  • Retinoic acid biosynthesis and metabolism.

    Joseph L. Napoli

  • Retinoic acid from the meninges regulates cortical neuron generation

    Julie A. Siegenthaler;Amir M. Ashique;Konstantinos Zarbalis;Katelin P. Patterson

  • Physiological insights into all-trans-retinoic acid biosynthesis

    Joseph L. Napoli

  • Quantification of endogenous retinoic acid in limited biological samples by LC/MS/MS

    Maureen A. Kane;Na Chen;Susan Sparks;Joseph L. Napoli

  • Retinoic Acid: Its Biosynthesis and Metabolism

    Joseph L. Napoli

  • Quantitative Profiling of Endogenous Retinoic Acid in Vivo and in Vitro by Tandem Mass Spectrometry

    Maureen A. Kane;Alexandra E. Folias;Chao Wang;Joseph L. Napoli

  • Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: effects on retinoid metabolism, function and related diseases

    Joseph L. Napoli

  • Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate.

    Xianshu Wang;Peter Penzes;Joseph L. Napoli

  • All-trans-retinoic acid stimulates translation and induces spine formation in hippocampal neurons through a membrane-associated RARα

    Na Chen;Joseph L. Napoli

  • HPLC/UV quantitation of retinal, retinol, and retinyl esters in serum and tissues

    Maureen A. Kane;Alexandra E. Folias;Joseph L. Napoli

  • Changing Patterns of the Retinoic Acid System in the Developing Retina

    Peter McCaffery;Katalin C. Posch;Joseph L. Napoli;Lorraine Gudas

  • Cloning of a cDNA for liver microsomal retinol dehydrogenase. A tissue-specific, short-chain alcohol dehydrogenase.

    Xiyun Chai;Manja H.E.M. Boerman;Yan Zhai;Joseph L. Napoli

  • Quantification of retinoic acid by gas-liquid chromatography-mass spectrometry: total versus all-trans-retinoic acid in human plasma.

    Joseph L. Napoli;Bikash C. Pramanik;John B. Williams;Marcia I. Dawson

  • Quantification of Endogenous Retinoids

    Maureen A. Kane;Joseph L. Napoli

  • Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells.

    Min Lin;Min Zhang;Michael Abraham;Susan M. Smith

  • Discrimination in the metabolism of orally dosed ergocalciferol and cholecalciferol by the pig, rat and chick.

    R L Horst;J L Napoli;E T Littledike

  • Biosynthesis of all-trans-retinoic acid from retinal. Recognition of retinal bound to cellular retinol binding protein (type I) as substrate by a purified cytosolic dehydrogenase.

    K C Posch;R D Burns;J L Napoli

  • Metabolism of retinoic acid and retinol during differentiation of F9 embryonal carcinoma cells.

    John B. Williams;Joseph L. Napoli

  • Holocellular retinol binding protein as a substrate for microsomal retinal synthesis.

    Katalin C. Posch;Manja H. E. M. Boerman;Robbin D. Burns;Joseph L. Napoli

Frequent Co-Authors

Ronald L. Horst
Ronald L. Horst Heartland Assays, LLC
Hector F. DeLuca
Hector F. DeLuca University of Wisconsin–Madison
Timothy A. Reinhardt
Timothy A. Reinhardt Agricultural Research Service
Heinrich K. Schnoes
Heinrich K. Schnoes University of Wisconsin–Madison
Donald C. Beitz
Donald C. Beitz Iowa State University
Milan R. Uskokovic
Milan R. Uskokovic Roche (Switzerland)
Andrew S. Peterson
Andrew S. Peterson Stanford University
Rune Blomhoff
Rune Blomhoff Oslo University Hospital
Robert N. Taylor
Robert N. Taylor University of Utah
Yasmine Belkaid
Yasmine Belkaid National Institute of Allergy and Infectious Diseases

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