Janet R. Sparrow

Overview

Best Publications

• The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

  Janet R. Sparrow;Koji Nakanishi;Craig A. Parish

  778
  Citations

• RPE lipofuscin and its role in retinal pathobiology.

  Janet R. Sparrow;Mike Boulton

  747
  Citations

• Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

  Craig A. Parish;Masaru Hashimoto;Koji Nakanishi;James Dillon

  565
  Citations

• Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium

  Jilin Zhou;Young Pyo Jang;So Ra Kim;Janet R. Sparrow

  420
  Citations

• Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

  Janet R. Sparrow;Jilin Zhou;Shimon Ben-Shabat;Heidi Vollmer

  394
  Citations

• A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

  Janet R. Sparrow;Craig A. Parish;Masaru Hashimoto;Koji Nakanishi

  390
  Citations

• The bisretinoids of retinal pigment epithelium.

  Janet R. Sparrow;Emily Gregory-Roberts;Kazunori Yamamoto;Anna Blonska

  377
  Citations

• A2E-epoxides Damage DNA in Retinal Pigment Epithelial Cells VITAMIN E AND OTHER ANTIOXIDANTS INHIBIT A2E-EPOXIDE FORMATION

  Janet R. Sparrow;Heidi R. Vollmer-Snarr;Jilin Zhou;Young P. Jang

  362
  Citations

• Blue Light–Induced Apoptosis of A2E-Containing RPE: Involvement of Caspase-3 and Protection by Bcl-2

  Janet R. Sparrow;Bolin Cai

  358
  Citations

• Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice

  Mariacarmela Allocca;Monica Doria;Marco Petrillo;Pasqualina Colella

  349
  Citations

• CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium

  Sandra W. Ryeom;Janet R. Sparrow;Roy L. Silverstein

  297
  Citations

• Blue light-absorbing intraocular lens and retinal pigment epithelium protection in vitro

  Janet R Sparrow;Ashley S Miller;Jilin Zhou

  286
  Citations

• The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane.

  Jianghua Liu;Yasuhiro Itagaki;Shimon Ben-Shabat;Koji Nakanishi

  285
  Citations

• SOD2 knockdown mouse model of early AMD

  Verline Justilien;Ji-Jing Pang;Kutralanathan Renganathan;Xianquan Zhan

  261
  Citations

• Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy.

  J. Kong;S.-R. Kim;K. Binley;I. Pata

  261
  Citations

• Phospholipid meets all-trans-retinal: the making of RPE bisretinoids

  Janet R. Sparrow;Yalin Wu;Chul Y. Kim;Jilin Zhou

  258
  Citations

• Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells

  Qingning Bian;Shasha Gao;Shasha Gao;Jilin Zhou;Jian Qin

  256
  Citations

• Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin.

  So Ra Kim;Koji Nakanishi;Yasuhiro Itagaki;Janet R. Sparrow

  252
  Citations

• Experimental studies of tolerance to intravitreal perfluoro-n-octane liquid.

  Stanley Chang;Janet R. Sparrow;Takeo Iwamoto;Abbey Gershbein

  247
  Citations

• Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin.

  Shimon Ben-Shabat;Craig A. Parish;Heidi R. Vollmer;Yasuhiro Itagaki

  246
  Citations