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D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
9029
World Ranking
17206
National Ranking
735

Overview

Deniz Dalkara is affiliated with Inserm, the Institut national de la santé et de la recherche médicale in France. Their research spans several fields, primarily focusing on biochemistry, genetics, molecular biology, and neuroscience. Within these areas, they have contributed extensively to molecular biology and cellular and molecular neuroscience.

Their research topics cover a range of areas related to vision and neural function. These include retinal development and disorders, photoreceptor and optogenetics research, CRISPR and genetic engineering, virus-based gene therapy, neuroscience and neural engineering, retinal diseases and treatments, and neural dynamics and brain function.

Deniz Dalkara has published in multiple journals and venues, frequently contributing to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Therapy - Methods & Clinical Development
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • Scientific Reports

Several recent papers illustrate the focus of their work. These include:

  • Partial recovery of visual function in a blind patient after optogenetic therapy, 2021, Nature Medicine
  • Early and late stage gene therapy interventions for inherited retinal degenerations, 2021, Progress in Retinal and Eye Research
  • Neural circuits in the mouse retina support color vision in the upper visual field, 2020, Nature Communications
  • Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates, 2021, Communications Biology
  • Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety, 2021, Neuron

Their collaborative work features frequent coauthors such as José-Alain Sahel, Serge Picaud, Mélissa Desrosiers, Olivier Marre, and Ulisse Ferrari, indicating ongoing partnerships within their research community.

Best Publications

  • In Vivo???Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous

    Deniz Dalkara;Leah C. Byrne;Ryan R. Klimczak;Meike Visel

  • Partial recovery of visual function in a blind patient after optogenetic therapy

    José-Alain Sahel;Elise Boulanger-Scemama;Chloé Pagot;Angelo Arleo

  • Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.

    Najate Aït-Ali;Najate Aït-Ali;Najate Aït-Ali;Ram Fridlich;Ram Fridlich;Ram Fridlich;Géraldine Millet-Puel;Géraldine Millet-Puel;Géraldine Millet-Puel;Emmanuelle Clérin;Emmanuelle Clérin;Emmanuelle Clérin

  • Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous.

    Deniz Dalkara;Kathleen D Kolstad;Natalia Caporale;Meike Visel

  • A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells.

    Ryan R. Klimczak;James T. Koerber;Deniz Dalkara;John G. Flannery;John G. Flannery

  • Intravitreal Injection of AAV2 Transduces Macaque Inner Retina

    Lu Yin;Kenneth Greenberg;Kenneth Greenberg;Jennifer J. Hunter;Deniz Dalkara

  • Emerging therapies for inherited retinal degeneration

    Hendrik P.N. Scholl;Hendrik P.N. Scholl;Rupert W. Strauss;Mandeep S. Singh;Deniz Dalkara;Deniz Dalkara;Deniz Dalkara

  • Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice

    Emilie Macé;Emilie Macé;Emilie Macé;Romain Caplette;Romain Caplette;Romain Caplette;Olivier Marre;Olivier Marre;Olivier Marre;Abhishek Sengupta;Abhishek Sengupta;Abhishek Sengupta

  • Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery

    James T. Koerber;Ryan Klimczak;Jae Hyung Jang;Deniz Dalkara

  • LiGluR restores visual responses in rodent models of inherited blindness.

    Natalia Caporale;Kathleen D Kolstad;Trevor Lee;Ivan Tochitsky

  • Rapid optical control of nociception with an ion-channel photoswitch

    Alexandre Mourot;Timm Fehrentz;Timm Fehrentz;Yves Le Feuvre;Yves Le Feuvre;Caleb M Smith

  • Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina.

    Abhishek Sengupta;Abhishek Sengupta;Abhishek Sengupta;Antoine Chaffiol;Antoine Chaffiol;Antoine Chaffiol;Emilie Macé;Emilie Macé;Emilie Macé;Romain Caplette;Romain Caplette;Romain Caplette

  • A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina.

    Antoine Chaffiol;Antoine Chaffiol;Antoine Chaffiol;Romaine Caplette;Romaine Caplette;Romaine Caplette;Céline Jaillard;Céline Jaillard;Céline Jaillard;Elena Brazhnikova;Elena Brazhnikova;Elena Brazhnikova

  • Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration

    Leah C. Byrne;Deniz Dalkara;Gabriel Luna;Steven K. Fisher

  • Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve

    Vincent Pernet;Sandrine Joly;Deniz Dalkara;Noémie Jordi

  • Let There Be Light: Gene and Cell Therapy for Blindness

    Deniz Dalkara;Olivier Goureau;Katia Marazova;José Alain Sahel;José Alain Sahel

  • Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve.

    Pernet;Joly S;Jordi N;Dalkara D

  • AAV Mediated GDNF Secretion From Retinal Glia Slows Down Retinal Degeneration in a Rat Model of Retinitis Pigmentosa

    Deniz Dalkara;Deniz Dalkara;Kathleen D Kolstad;Karen I Guerin;Natalie V Hoffmann

  • Early and late stage gene therapy interventions for inherited retinal degenerations.

    Catherine Botto;Marco Rucli;Müge Defne Tekinsoy;Juliette Pulman

  • Noninvasive gene delivery to foveal cones for vision restoration

    Hanen Khabou;Marcela Garita-Hernandez;Antoine Chaffiol;Sacha Reichman

Frequent Co-Authors

José-Alain Sahel
José-Alain Sahel University of Pittsburgh
Serge Picaud
Serge Picaud Institut de la Vision
John G. Flannery
John G. Flannery University of California, Berkeley
David V. Schaffer
David V. Schaffer University of California, Berkeley
William H. Merigan
William H. Merigan University of Rochester
Thierry Léveillard
Thierry Léveillard Institut de la Vision
Botond Roska
Botond Roska University of Basel
Ryad Benosman
Ryad Benosman University of Pittsburgh
Philippe Hantraye
Philippe Hantraye University of Paris-Saclay
Richard H. Kramer
Richard H. Kramer University of California, Berkeley

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