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D-Index
82
Citations
24725
World Ranking
16113
National Ranking
527

Overview

Philippe Hantraye is affiliated with the University of Paris-Saclay in France, focusing on multiple aspects of neuroscience and related fields. Their research spans Neuroscience, Medicine, and Biochemistry, Genetics and Molecular Biology, with significant contributions to cellular and molecular neuroscience, neurology, and molecular biology.

Their main areas of study include Genetic Neurodegenerative Diseases, Parkinson's Disease Mechanisms and Treatments, Alzheimer's Disease research and treatments, and Neuroinflammation and Neurodegeneration Mechanisms. Additional topics cover Photoreceptor and optogenetics research, Neuroscience and Neural Engineering, as well as Retinal Development and Disorders.

Frequent publication venues for their work include Brain, Neurobiology of Disease, PLoS ONE, bioRxiv (Cold Spring Harbor Laboratory), and Research Square (Research Square).

Among their recent papers are:

  • Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease, 2020, Cell Metabolism
  • Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates, 2021, Communications Biology
  • Increased microglial activation in patients with Parkinson disease using [18F]-DPA714 TSPO PET imaging, 2020, Parkinsonism & Related Disorders
  • Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway, 2022, Brain
  • A new safety index based on intrapulse monitoring of ultra-harmonic cavitation during ultrasound-induced blood-brain barrier opening procedures, 2020, Scientific Reports

Philippe Hantraye has collaborated extensively with several co-authors, including Alexis-Pierre Bemelmans, Emmanuel Brouillet, Gilles Bonvento, Martine Guillermier, and Karine Cambon.

Best Publications

  • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.

    Jeffrey H. Kordower;Marina E. Emborg;Jocelyne Bloch;Shuang Y. Ma

  • INHIBITION OF NEURONAL NITRIC OXIDE SYNTHASE PREVENTS MPTP-INDUCED PARKINSONISM IN BABOONS

    P Hantraye;E Brouillet;R Ferrante;R Ferrante;S Palfi

  • Replicating Huntington's disease phenotype in experimental animals

    Emmanuel Brouillet;Françoise Condé;M.F Beal;Philippe Hantraye

  • Motor and cognitive improvements in patients with Huntington's disease after neural transplantation.

    Anne-Catherine Bachoud-Lévi;Philippe Rémy;Jean-Paul Nǵuyen;Pierre Brugières

  • Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

    E Brouillet;P Hantraye;R J Ferrante;R Dolan

  • Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

    Stéphane Palfi;Jean Marc Gurruchaga;G Scott Ralph;Helene Lepetit

  • Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson's Disease.

    Shane Grealish;Elsa Diguet;Agnete Kirkeby;Bengt Mattsson

  • In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's Disease subjects

    Mathilde Faideau;Jinho Kim;Kerry Cormier;Richard Gilmore

  • Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study

    Anne-Catherine Bachoud-Lévi;Véronique Gaura;Pierre Brugières;Jean-Pascal Lefaucheur

  • Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

    Sonia Lavisse;Martine Guillermier;Anne-Sophie Hérard;Fanny Petit

  • Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease.

    Dwaine F. Emerich;Shelley R. Winn;Philippe M. Hantraye;Marc Peschanski

  • Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease.

    S Palfi;R J Ferrante;E Brouillet;M F Beal

  • Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon

    M. Peschanski;G. Defer;J. P. N'Guyen;F. Ricolfi

  • MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons.

    N W Kowall;P Hantraye;E Brouillet;M F Beal

  • The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

    Lucile Ben Haim;Lucile Ben Haim;Kelly Ceyzériat;Kelly Ceyzériat;Maria Angeles Carrillo-de Sauvage;Maria Angeles Carrillo-de Sauvage;Fabien Aubry;Fabien Aubry

  • Partial Inhibition of Brain Succinate Dehydrogenase by 3‐Nitropropionic Acid Is Sufficient to Initiate Striatal Degeneration in Rat

    Emmanuel Brouillet;Marie-Caroline Guyot;Vincent Mittoux;Séverine Altairac

  • Involvement of Mitochondrial Complex II Defects in Neuronal Death Produced by N-Terminus Fragment of Mutated Huntingtin

    Alexandra Benchoua;Yaël Trioulier;Diana Zala;Marie-Claude Gaillard

  • Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

    Simon Dujardin;Simon Dujardin;Katia Lécolle;Katia Lécolle;Raphaëlle Caillierez;Raphaëlle Caillierez;Séverine Bégard;Séverine Bégard

  • Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study.

    J. Bloch;A.C. Bachoud-Lévi;N. Déglon;J.P. Lefaucheur

  • Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

    Maria Borrell-Pagès;Josep M. Canals;Fabrice P. Cordelières;J. Alex Parker

Frequent Co-Authors

Emmanuel Brouillet
Emmanuel Brouillet Centre national de la recherche scientifique, CNRS
Nicole Déglon
Nicole Déglon University of Lausanne
Marc Dhenain
Marc Dhenain University of Paris-Saclay
Gilles Bonvento
Gilles Bonvento University of Paris-Saclay
Marc Peschanski
Marc Peschanski Grenoble Alpes University
Anne-Catherine Bachoud-Lévi
Anne-Catherine Bachoud-Lévi École Normale Supérieure
Frédéric Dollé
Frédéric Dollé French Alternative Energies and Atomic Energy Commission (CEA)
Luc Buée
Luc Buée University of Lille
Patrick Aebischer
Patrick Aebischer École Polytechnique Fédérale de Lausanne
Ole Isacson
Ole Isacson Harvard University

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