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Neuroscience

D-Index
69
Citations
17305
World Ranking
2621
National Ranking
86

Overview

Emmanuel Brouillet is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research primarily focuses on neuroscience, biochemistry, genetics, molecular biology, and medicine. The scientist's work spans several interconnected subfields, including molecular biology, cellular and molecular neuroscience, neurology, physiology, and imaging techniques such as radiology and nuclear medicine.

Key areas of study in their research include genetic neurodegenerative diseases, mitochondrial function and pathology, Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, Parkinson's disease mechanisms and treatments, RNA research and splicing, as well as broader neurological disorders and treatments.

Emmanuel Brouillet has contributed to numerous publications in notable scientific venues. Frequent publication venues include:

  • Brain
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Research Square (Research Square)
  • Neurobiology of Disease
  • Frontiers in Molecular Neuroscience

Their recent papers demonstrate a focus on mechanisms underlying neurodegenerative diseases and astrocyte function. Selected recent publications are:

  • "Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease" (2020, Cell Metabolism)
  • "Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway" (2022, Brain)
  • "Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state" (2021, Brain)
  • "Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain" (2021, Journal of Neuroinflammation)
  • "Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease" (2020, Neurobiology of Aging)

The scientist collaborates with several frequent co-authors, including:

  • Alexis-Pierre Bemelmans
  • Julien Flament
  • Gilles Bonvento
  • Philippe Hantraye
  • J. Pérot

Best Publications

  • Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

    MF Beal;E Brouillet;BG Jenkins;RJ Ferrante

  • INHIBITION OF NEURONAL NITRIC OXIDE SYNTHASE PREVENTS MPTP-INDUCED PARKINSONISM IN BABOONS

    P Hantraye;E Brouillet;R Ferrante;R Ferrante;S Palfi

  • Replicating Huntington's disease phenotype in experimental animals

    Emmanuel Brouillet;Françoise Condé;M.F Beal;Philippe Hantraye

  • Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

    E Brouillet;P Hantraye;R J Ferrante;R Dolan

  • Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.

    E. Brouillet;B. G. Jenkins;B. T. Hyman;R. J. Ferrante

  • Age‐Dependent Striatal Excitotoxic Lesions Produced by the Endogenous Mitochondrial Inhibitor Malonate

    M F Beal;E Brouillet;B Jenkins;R Henshaw

  • In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's Disease subjects

    Mathilde Faideau;Jinho Kim;Kerry Cormier;Richard Gilmore

  • 3‐Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease

    Emmanuel Brouillet;Carine Jacquard;Nicolas Bizat;David Blum

  • Manganese Injection into the Rat Striatum Produces Excitotoxic Lesions by Impairing Energy Metabolism

    E P Brouillet;L Shinobu;U McGarvey;F Hochberg

  • Chronic 3-nitropropionic acid treatment in baboons replicates the cognitive and motor deficits of Huntington's disease.

    S Palfi;R J Ferrante;E Brouillet;M F Beal

  • Mitochondria in Huntington's disease

    Maria Damiano;Laurie Galvan;Laurie Galvan;Nicole Déglon;Nicole Déglon;Emmanuel Brouillet;Emmanuel Brouillet

  • MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons.

    N W Kowall;P Hantraye;E Brouillet;M F Beal

  • The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

    Lucile Ben Haim;Lucile Ben Haim;Kelly Ceyzériat;Kelly Ceyzériat;Maria Angeles Carrillo-de Sauvage;Maria Angeles Carrillo-de Sauvage;Fabien Aubry;Fabien Aubry

  • Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease.

    Juliette Le Douce;Marianne Maugard;Julien Veran;Julien Veran;Marco Matos;Marco Matos

  • Partial Inhibition of Brain Succinate Dehydrogenase by 3‐Nitropropionic Acid Is Sufficient to Initiate Striatal Degeneration in Rat

    Emmanuel Brouillet;Marie-Caroline Guyot;Vincent Mittoux;Séverine Altairac

  • Involvement of Mitochondrial Complex II Defects in Neuronal Death Produced by N-Terminus Fragment of Mutated Huntingtin

    Alexandra Benchoua;Yaël Trioulier;Diana Zala;Marie-Claude Gaillard

  • Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

    Kelly Ceyzériat;Kelly Ceyzériat;Lucile Ben Haim;Lucile Ben Haim;Lucile Ben Haim;Audrey Denizot;Audrey Denizot;Dylan Pommier;Dylan Pommier

  • Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

    Maria Borrell-Pagès;Josep M. Canals;Fabrice P. Cordelières;J. Alex Parker

  • Sustained effects of nonallele-specific Huntingtin silencing†

    Valérie Drouet;Valérie Drouet;Valérie Perrin;Raymonde Hassig;Raymonde Hassig;Noëlle Dufour;Noëlle Dufour

  • 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.

    Elsdon Storey;Bradley T. Hyman;Bruce Jenkins;Emmanuel Brouillet

  • Dopamine Gene Therapy for Parkinson’s Disease in a Nonhuman Primate Without Associated Dyskinesia

    Béchir Jarraya;Sabrina Boulet;G. Scott Ralph;Caroline Jan

  • Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid

    M.-C Guyot;P Hantraye;R Dolan;S Palfi

Frequent Co-Authors

Gilles Bonvento
Gilles Bonvento University of Paris-Saclay
Marc Dhenain
Marc Dhenain University of Paris-Saclay
Robert J. Ferrante
Robert J. Ferrante Boston University
Marc Peschanski
Marc Peschanski Grenoble Alpes University
M. Flint Beal
M. Flint Beal Cornell University
Patrick Aebischer
Patrick Aebischer École Polytechnique Fédérale de Lausanne
Jordi Alberch
Jordi Alberch University of Barcelona
Bruno Cauli
Bruno Cauli Sorbonne University
Jean-François Deleuze
Jean-François Deleuze University of Paris-Saclay

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