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Luís Pereira de Almeida

Luís Pereira de Almeida

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
9058
World Ranking
15761
National Ranking
64

Overview

Luís Pereira de Almeida is affiliated with the University of Coimbra in Portugal and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Their work spans several subfields, including Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Genetics, and Physiology.

The main topics covered in their scientific research include Genetic Neurodegenerative Diseases, Mitochondrial Function and Pathology, Extracellular vesicles in disease, Parkinson's Disease Mechanisms and Treatments, RNA Interference and Gene Delivery, Neurological disorders and treatments, and MicroRNA in disease regulation.

Luís Pereira de Almeida has contributed to several notable publications. Selected recent papers include:

  • Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation? (2021), Cell Death and Disease
  • Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice (2020), EMBO Molecular Medicine
  • miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease (2020), Molecular Therapy - Nucleic Acids
  • Tau and neurofilament light-chain as fluid biomarkers in spinocerebellar ataxia type 3 (2022), European Journal of Neurology
  • Brain-targeted drug delivery - nanovesicles directed to specific brain cells by brain-targeting ligands (2024), Journal of Nanobiotechnology

Their research outputs are frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), International Journal of Molecular Sciences, Molecular Therapy, Brain, and The Cerebellum.

They collaborate extensively with other researchers in their field. Frequent co-authors include Magda M. Santana, Rui Jorge Nobre, Jon Infante, Lüdger Schöls, and Paola Giunti, indicating a network of ongoing scientific partnerships supporting their research activities.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Pharmacokinetic and safety profile of trans‐resveratrol in a rising multiple‐dose study in healthy volunteers

    Luis Almeida;Manuel Vaz-da-Silva;Amílcar Falcão;Eva Soares

  • Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases.

    David Rufino-Ramos;Patrícia R. Albuquerque;Vitor Carmona;Rita Perfeito

  • miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

    Ana L Cardoso;Joana R Guedes;Luís Pereira de Almeida;Maria C Pedroso de Lima

  • Lentiviral-Mediated Delivery of Mutant Huntingtin in the Striatum of Rats Induces a Selective Neuropathology Modulated by Polyglutamine Repeat Size, Huntingtin Expression Levels, and Protein Length

    Luis Pereira de Almeida;Christopher A. Ross;Diana Zala;Diana Zala;Patrick Aebischer;Patrick Aebischer

  • Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.

    Maria João Bonifácio;P. Nuno Palma;Luís Almeida;Luís Almeida;Patrício Soares-da-Silva;Patrício Soares-da-Silva

  • Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.

    Isabel Nascimento-Ferreira;Isabel Nascimento-Ferreira;Tiago Santos-Ferreira;Lígia Sousa-Ferreira;Gwennaëlle Auregan;Gwennaëlle Auregan

  • Eslicarbazepine acetate (BIA 2-093).

    Luis Almeida;Patrício Soares-da-Silva

  • MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma.

    Pedro M. Costa;Ana L. Cardoso;Carlos Custódia;Pedro Cunha

  • Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9.

    Joana Saraiva;Rui Jorge Nobre;Luis Pereira de Almeida

  • Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease.

    Sandro Alves;Sandro Alves;Isabel Nascimento-Ferreira;Gwennaëlle Auregan;Gwennaëlle Auregan;Raymonde Hassig;Raymonde Hassig

  • Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model

    Joana R. Guedes;Carlos M. Custódia;Ricardo J. Silva;Luís P. de Almeida

  • Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice

    Clévio Nóbrega;Isabel Nascimento-Ferreira;Isabel Onofre;David Albuquerque

  • Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado–Joseph disease

    Ana T. Simões;Nélio Gonçalves;Arnulf Koeppen;Nicole Déglon

  • Effect of food on the pharmacokinetic profile of trans-resveratrol.

    Vaz-da-Silva M;Loureiro Ai;Falcao A;Nunes T

  • Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects.

    Luis Almeida;Amílcar Falcão;Joana Maia;Dago Mazur

  • Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

    Sandro Alves;Isabel Nascimento-Ferreira;Noëlle Dufour;Noëlle Dufour;Raymonde Hassig;Raymonde Hassig

  • Role of hypothalamic neurogenesis in feeding regulation

    Lígia Sousa-Ferreira;Luís Pereira de Almeida;Cláudia Cavadas

  • Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?

    Adriana Marcelo;Rebekah Koppenol;Luís Pereira de Almeida;Carlos A. Matos

  • Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment.

    Pedro M Costa;Ana L Cardoso;Liliana S Mendonça;Angelo Serani

Frequent Co-Authors

Nicole Déglon
Nicole Déglon University of Lausanne
Hirokazu Hirai
Hirokazu Hirai Gunma University
Thomas Klockgether
Thomas Klockgether German Center for Neurodegenerative Diseases
Sebastian Kügler
Sebastian Kügler University of Göttingen
Ludger Schöls
Ludger Schöls University of Tübingen
Emmanuel Brouillet
Emmanuel Brouillet Centre national de la recherche scientifique, CNRS
Kathrin Reetz
Kathrin Reetz RWTH Aachen University
Carlos B. Duarte
Carlos B. Duarte University of Coimbra
Arnulf H. Koeppen
Arnulf H. Koeppen Louis Stokes Cleveland VA Medical Center

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