World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
13956
World Ranking
10786
National Ranking
42

Overview

Dora Brites is affiliated with the University of Lisbon in Portugal and has an extensive research portfolio spanning neuroscience, medicine, and biochemistry, genetics, and molecular biology. Their work predominantly focuses on neuroinflammation and neurodegeneration mechanisms, with significant contributions to amyotrophic lateral sclerosis (ALS) research, extracellular vesicles in disease, and microRNA regulation in disease contexts.

The scientist's main research fields include:

  • Neuroscience
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these areas, their subfields of study cover:

  • Neurology
  • Molecular Biology
  • Immunology
  • Cancer Research
  • Physiology

Dora Brites has published work relating to various key topics, including:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Amyotrophic Lateral Sclerosis Research
  • Extracellular vesicles in disease
  • MicroRNA in disease regulation
  • Immune cells in cancer
  • Alzheimer's disease research and treatments
  • Neurogenetic and Muscular Disorders Research

Prominent publication venues for their research include:

  • International Journal of Molecular Sciences
  • Zenodo (CERN European Organization for Nuclear Research)
  • Frontiers in Pharmacology
  • Cells
  • Stem Cell Reports

Their frequent collaborators consist of Ana Rita Vaz, Gonçalo Garcia, Adelaide Fernandes, Daniel C. Anthony, and Cristovam Wanderley Picanço Diniz.

Selected recent papers authored or co-authored by Dora Brites showcase a focus on microglial biology, neurodegenerative diseases, and molecular mechanisms underlying neurological conditions:

  • "Microglia states and nomenclature: A field at its crossroads," 2022, Neuron
  • "Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies," 2020, Stem Cell Reports
  • "Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons," 2021, Frontiers in Cell and Developmental Biology
  • "Regulatory function of microRNAs in microglia," 2020, Glia
  • "Overexpression of miR-124 in Motor Neurons Plays a Key Role in ALS Pathological Processes," 2021, International Journal of Molecular Sciences

Best Publications

  • Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches.

    Filipa Lourenço Cardoso;Dora Brites;Maria Alexandra Brito

  • Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

    Dora Brites;Adelaide Fernandes

  • Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation.

    Joao Rocha;Maria Eduardo-Figueira;Andreia Barateiro;Adelaide Fernandes

  • Neurovascular Unit: a Focus on Pericytes

    Inês Sá-Pereira;Dora Brites;Maria Alexandra Brito

  • Polyphenols journey through blood-brain barrier towards neuronal protection.

    Inês Figueira;Gonçalo Garcia;Rui C. Pimpão;A. P. Terrasso

  • Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

    Michael J Bernas;Filipa L Cardoso;Sarah K Daley;Martin E Weinand

  • Microglia centered pathogenesis in ALS: insights in cell interconnectivity.

    Dora Brites;Ana R. Vaz

  • Molecular basis of bilirubin-induced neurotoxicity

    J.Donald Ostrow;Lorella Pascolo;Dora Brites;Claudio Tiribelli

  • Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta

    Maria A. Serrano;Dora Brites;Monica G. Larena;Maria J. Monte

  • Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons

    Cecília M. P. Rodrigues;Susana Solá;Dora Brites

  • Microglia change from a reactive to an age-like phenotype with the time in culture

    Cláudia Caldeira;Ana F. Oliveira;Carolina Cunha;Ana R. Vaz

  • Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization.

    Carolina Cunha;Cátia Gomes;Ana Rita Vaz;Dora Brites

  • Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy

    Dora Brites;Cecília M.P. Rodrigues;Nuno Oliveira;Maria da Conceição Cardoso

  • Bilirubin and amyloid-beta peptide induce cytochrome c release through mitochondrial membrane permeabilization

    Cecília M. P. Rodrigues;Susana Solá;Rui Silva;Dora Brites

  • Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal

    Dora Brites;Cecı́lia M.P Rodrigues;Helena van-Zeller;Alexandra Brito

  • Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype.

    Sara Pinto;Carolina Cunha;Marta Barbosa;Ana R. Vaz

  • The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation.

    Dora Brites

  • Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

    Adelaide Fernandes;Ana S. Falcão;Rui F. M. Silva;Ana C. Gordo

  • A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes.

    Maria Alexandra Brito;Dora Brites;D. Allan Butterfield

  • Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid.

    Rui F.M. Silva;Cecı́lia M.P. Rodrigues;Dora Brites

Frequent Co-Authors

Cecília M. P. Rodrigues
Cecília M. P. Rodrigues University of Lisbon
João Rocha
João Rocha Universidade Federal de Santa Maria
Derek Stewart
Derek Stewart James Hutton Institute
Claudio Tiribelli
Claudio Tiribelli AREA Science Park
Ana M. Sebastião
Ana M. Sebastião University of Lisbon
Hiroyuki Sasaki
Hiroyuki Sasaki Jikei University School of Medicine
José J. G. Moura
José J. G. Moura Universidade Nova de Lisboa
Eduarda Fernandes
Eduarda Fernandes University of Porto
Gordon J. McDougall
Gordon J. McDougall James Hutton Institute
D. Allan Butterfield
D. Allan Butterfield University of Kentucky

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