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Neuroscience

D-Index
121
Citations
52848
World Ranking
376
National Ranking
27

Medicine

D-Index
121
Citations
52940
World Ranking
3614
National Ranking
193

Overview

Thomas Klockgether is affiliated with the University Hospital Bonn in Germany and has contributed extensively to the fields of neuroscience, biochemistry, genetics, molecular biology, and medicine. Their research focuses on cellular and molecular neuroscience, molecular biology, neurology, genetics, and physiology, with a particular emphasis on genetic neurodegenerative diseases and mitochondrial function and pathology.

Their scholarly output includes publications in various notable venues such as Movement Disorders, bioRxiv (Cold Spring Harbor Laboratory), Journal of Neurology, The Cerebellum, and Neurology. These venues have hosted a significant number of their works, reflecting a consistent engagement with high-impact journals in the neurological and biomedical research communities.

Among recent papers by Thomas Klockgether are:

  • Natural History, Phenotypic Spectrum, and Discriminative Features of Multisystemic RFC1 Disease (2021, Neurology)
  • Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS (2024, Nature Medicine)
  • Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice (2020, EMBO Molecular Medicine)
  • Progression characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS): a 4-year cohort study (2021, The Lancet Neurology)
  • Update cerebellum and cognition (2021, Journal of Neurology)

Frequent collaborators in their research include Jennifer Faber, Matthis Synofzik, Lüdger Schöls, Heike Jacobi, and Kathrin Reetz. These collaborations indicate active participation in multidisciplinary and multi-author projects related to neurological disorders.

Main topics covered in Thomas Klockgether's research are:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Parkinson's Disease Mechanisms and Treatments
  • Neurological disorders and treatments
  • DNA Repair Mechanisms
  • Amyotrophic Lateral Sclerosis Research
  • Genomics and Rare Diseases

Best Publications

  • Second consensus statement on the diagnosis of multiple system atrophy

    S. Gilman;G. K. Wenning;P. A. Low;D. J. Brooks

  • Consensus statement on the diagnosis of multiple system atrophy

    S Gilman;P.A Low;N Quinn;A Albanese

  • Scale for the assessment and rating of ataxia: development of a new clinical scale.

    T Schmitz-Hübsch;S Tezenas du Montcel;L Baliko;J Berciano

  • The phenotypic spectrum of CADASIL: clinical findings in 102 cases.

    M. Dichgans;M. Mayer;I. Uttner;R. Brüning

  • Spinocerebellar ataxia

    Unknown

  • Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

    Michael T Heneka;Magdalena Sastre;Lucia Dumitrescu-Ozimek;Anne Hanke

  • The natural history of multiple system atrophy: a prospective European cohort study

    Gregor K Wenning;Felix Geser;Felix Geser;Florian Krismer;Klaus Seppi

  • Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms.

    Magdalena Sastre;Thomas Klockgether;Michael T. Heneka

  • Nonsteroidal Anti-Inflammatory Drugs and Peroxisome Proliferator-Activated Receptor-γ Agonists Modulate Immunostimulated Processing of Amyloid Precursor Protein through Regulation of β-Secretase

    Magdalena Sastre;Ilse Dewachter;Gary E Landreth;Timothy M Willson

  • Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species

    Jörg B. Schulz;Michael Weller;Thomas Klockgether

  • Leitlinien für Diagnostik und Therapie in der Neurologie

    H. C. Diener;C. Weimar;P. Berlit;G. Deuschl

  • Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

    Magdalena Sastre;Ilse Dewachter;Steffen Rossner;Nenad Bogdanovic

  • Primary Central Nervous System Lymphoma: Results of a Pilot and Phase II Study of Systemic and Intraventricular Chemotherapy With Deferred Radiotherapy

    Hendrik Pels;Ingo G.H. Schmidt-Wolf;Axel Glasmacher;Holger Schulz

  • The natural history of degenerative ataxia: a retrospective study in 466 patients.

    T Klockgether;R Lüdtke;B Kramer;M Abele

  • Mutations in COQ2 in familial and sporadic multiple-system atrophy the multiple-system atrophy research collaboration

    Jun Mitsui;Takashi Matsukawa;Hiroyuki Ishiura;Yoko Fukuda;Yoko Fukuda

  • The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.

    Luisa Klotz;Sven Burgdorf;Indra Dani;Kaoru Saijo

  • Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice.

    Michael T Heneka;Magdalena Sastre;Lucia Dumitrescu-Ozimek;Ilse Dewachter

  • Chromosomal assignment of the second locus for autosomal dominant cerebellar ataxia (SCA2) to chromosome 12q23–24.1

    Gispert S;Twells R;Orozco G;Brice A

  • Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.

    Philipp Koch;Peter Breuer;Michael Peitz;Johannes Jungverdorben

  • Sleep attacks, daytime sleepiness, and dopamine agonists in Parkinson's disease.

    Sebastian Paus;Hans Michael Brecht;Jürgen Köster;Gert Seeger

  • NMDA antagonists potentiate antiparkinsonian actions of L-dopa in monoamine-depleted rats

    Thomas Klockgether;Lechoslaw Turski

  • Autosomal dominant cerebellar ataxia type I Clinical features and MRI in families with SCA1, SCA2 and SCA3

    K. Bürk;M. Abele;M. Fetter;J. Dichgans

Frequent Co-Authors

Jörg B. Schulz
Jörg B. Schulz RWTH Aachen University
Ludger Schöls
Ludger Schöls University of Tübingen
Ullrich Wüllner
Ullrich Wüllner University Hospital Bonn
Alexandra Durr
Alexandra Durr Sorbonne University
Johannes Dichgans
Johannes Dichgans University of Tübingen
Dagmar Timmann
Dagmar Timmann University of Duisburg-Essen
Paola Giunti
Paola Giunti University College London
Kathrin Reetz
Kathrin Reetz RWTH Aachen University
Massimo Pandolfo
Massimo Pandolfo McGill University

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