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Ming-Zong Lai

Ming-Zong Lai

Academia Sinica
Taiwan, Province of China

Overview

What is he best known for?

The fields of study he is best known for:

  • DNA
  • Apoptosis
  • Immune system

Ming-Zong Lai mainly focuses on Molecular biology, Cell biology, p38 mitogen-activated protein kinases, Nuclear protein and MAPK/ERK pathway. His work carried out in the field of Molecular biology brings together such families of science as Repressor, Promoter, Secretion and Protein kinase A. Much of his study explores Protein kinase A relationship to Transactivation.

Ming-Zong Lai focuses mostly in the field of Cell biology, narrowing it down to matters related to Fas receptor and, in some cases, Fas ligand. The concepts of his Nuclear protein study are interwoven with issues in Interleukin 2, NFAT and Coactivator. As a part of the same scientific study, Ming-Zong Lai usually deals with the Apoptosis, concentrating on Mediator and frequently concerns with T cell.

His most cited work include:

  • Immunological self, nonself discrimination. (254 citations)
  • Interaction of peptide antigens and class II major histocompatibility complex antigens (186 citations)
  • Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in culture. (184 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Cell biology, Molecular biology, Cancer research, T cell and Protein kinase A. His work in the fields of Cell biology, such as Signal transduction, overlaps with other areas such as Downregulation and upregulation. His Molecular biology research incorporates themes from CREB, T-cell receptor, Interleukin 2, MAP kinase kinase kinase and p38 mitogen-activated protein kinases.

His Cancer research research integrates issues from Inflammation, NFAT, Promyelocytic leukemia protein and Transactivation. His T cell study combines topics from a wide range of disciplines, such as T lymphocyte and Peptide. His Protein kinase A research includes themes of Tumor necrosis factor alpha and NFKB1.

He most often published in these fields:

  • Cell biology (84.17%)
  • Molecular biology (46.67%)
  • Cancer research (56.67%)

What were the highlights of his more recent work (between 2010-2020)?

  • Cell biology (84.17%)
  • Cancer research (56.67%)
  • Downregulation and upregulation (37.50%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cell biology, Cancer research, Downregulation and upregulation, Inflammasome and Protein kinase A. His study in Cell biology is interdisciplinary in nature, drawing from both Jurkat cells, Biochemistry and In vivo. His Cancer research research is multidisciplinary, incorporating perspectives in Inflammation, Cancer and Cyclin-dependent kinase 4.

His study on Caspase 1 is often connected to Tumor suppressor gene as part of broader study in Inflammation. His Inflammasome study integrates concerns from other disciplines, such as Tumor necrosis factor alpha and Suppressor. As part of one scientific family, Ming-Zong Lai deals mainly with the area of Protein kinase A, narrowing it down to issues related to the T cell, and often T lymphocyte.

Between 2010 and 2020, his most popular works were:

  • Tumor suppressor death-associated protein kinase is required for full IL-1β production. (52 citations)
  • Tumor suppressor death-associated protein kinase is required for full IL-1β production. (52 citations)
  • Tumor suppressor death-associated protein kinase is required for full IL-1β production. (52 citations)

In his most recent research, the most cited papers focused on:

  • DNA
  • Apoptosis
  • Immune system

His primary areas of study are Inflammasome, Cell biology, Cancer research, Tumor necrosis factor alpha and Protein kinase A. His Inflammasome research includes elements of HEK 293 cells, Flip and Virology. In general Cell biology, his work in Function is often linked to Downregulation and upregulation linking many areas of study.

Ming-Zong Lai has included themes like Suppressor, NLRP3 inflammasome activation and Promyelocytic leukemia protein in his Cancer research study. The study incorporates disciplines such as Inflammation, Caspase 1, Kinase and Cytokine in addition to Tumor necrosis factor alpha. His Signal transduction study combines topics in areas such as NFKB1, T cell, Immunology and Fas ligand.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Immunological self, nonself discrimination.

Jean-Gerard Guillet;Ming-Zong Lai;Thomas J. Briner;Soren Buus.
Science (1987)

371 Citations

Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in culture.

Chun-Jung Chu;Jan Dijkstra;Ming-Zong Lai;Keelung Hong.
Pharmaceutical Research (1990)

287 Citations

Interaction of peptide antigens and class II major histocompatibility complex antigens

Jean-Gerrard Guillet;Ming-Zong Lai;Thomas J. Briner;John A. Smith.
Nature (1986)

251 Citations

Fibronectin-mediated uptake of gelatin-coated latex particles by peritoneal macrophages.

P W Gudewicz;J Molnar;M Z Lai;D W Beezhold.
Journal of Cell Biology (1980)

217 Citations

DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation.

Huey-Lan Huang;Li-Wen Fang;Shu-Ping Lu;Chen-Kung Chou.
Oncogene (2003)

179 Citations

Effects of replacement of the hydroxyl group of cholesterol and tocopherol on the thermotropic behavior of phospholipid membranes.

Ming Zong Lai;Nejat Duzgunes;Francis C. Szoka.
Biochemistry (1985)

171 Citations

Mitogen-activated Protein Kinase Kinase Antagonized Fas-associated Death Domain Protein-mediated Apoptosis by Induced FLICE-inhibitory Protein Expression

Jung-Hua Yeh;Shu-Ching Hsu;Shou-Hwa Han;Ming-Zong Lai.
Journal of Experimental Medicine (1998)

162 Citations

c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes

Yi-Ping Hsueh;Yi-Ping Hsueh;Ming-Zong Lai;Ming-Zong Lai.
Journal of Biological Chemistry (1995)

129 Citations

Nitric oxide increased interleukin‐4 expression in T lymphocytes

R.-H. Chang;M.-H. Lin Feng;W.-H. Liu;M.-Z. Lai.
Immunology (1997)

121 Citations

Acid- and calcium-induced structural changes in phosphatidylethanolamine membranes stabilized by cholesteryl hemisuccinate.

Ming Zong Lai;William J. Vail;Francis C. Szoka.
Biochemistry (1985)

118 Citations

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